Notes

Supported on the internet mental behavioural remedy regarding bulimia therapy: a survey protocol of an randomised manipulated tryout.
Postnatal exposure was associated with 16-19% higher risks for parent-reported internalizing behaviors, but the associations were weak or null for child-reported scores except for prosocial behavior. Our study corroborates published associations between prenatal exposures to acetaminophen and behavioral problems and extends the literature to early adolescence.
Larger brain volumes are often associated with more free-living physical activity (PA) in cognitively normal older adults. SC75741 manufacturer Yet, whether greater brain volumes are associated with more favorable (less fragmented) PA patterns, and whether this association is stronger than with total PA, remains unknown.

Brain magnetic resonance imaging and wrist-worn accelerometer data were collected in 301 participants (mean age=77[SD=7] years, 59% women) enrolled in the Baltimore Longitudinal Study of Aging. Linear regression models were fit to examine whether brain volumes (cc) were cross-sectionally associated with 1) total daily PA minutes; and 2) activity fragmentation (mean number of PA bouts / total PA minutes x 100). Sensitivity analyses were conducted by adjusting for counterpart PA variables (e.g., fragmentation covariate included in the PA minutes model).

Greater white matter volumes in the parietal and temporal lobes were associated with higher daily PA minutes (2.6(SE=1.0) and 3.8(0.9)min/day, respectively; p function and PA patterns with aging.This paper presents a series of electromagnetic field measurements performed on the campus of Ferdowsi University of Mashhad in order to assess the compliance of radiation levels of cellular base stations and WiFi access points with international guidelines. A calibrated, broadband and isotropic probe is used and recommendations of International Telecommunication Union (ITU) are followed up throughout measurements. More than 300 outdoor and indoor locations have been systematically chosen for measurements. The recorded data are post-processed and compared with the guideline of International Commission on Non-Ionizing Radiation Protection (ICNIRP). Measured power densities of WiFi access points are low and do not exceed 1% of the level allowed by ICNIRP. For cellular base stations, measured power density is usually low outdoors, but reaches up to 16% of the allowed radiation level in publicly accessible indoor locations. Comprehensive exposure assessment, as recommended by ITU, has been performed to estimate the maximum possible radiation of one indoor base station. It is concluded that precautionary actions have to be taken by university authorities to limit the presence of students in close proximity to specific indoor antennas. Moreover, comprehensive exposure assessment is more likely necessary for indoor base stations whereas such assessment is not usually required outdoors.
Reproducibility is of central importance to the scientific process. The difficulty of consistently replicating and verifying experimental results is magnified in the era of big data, in which bioinformatics analysis often involves complex multi-application pipelines operating on terabytes of data. These processes result in thousands of possible permutations of data preparation steps, software versions and command-line arguments. Existing reproducibility frameworks are cumbersome and involve redesigning computational methods. To address these issues, we developed RepeatFS, a file system that records, replicates and verifies informatics workflows with no alteration to the original methods. RepeatFS also provides several other features to help promote analytical transparency and reproducibility, including provenance visualization and task automation.

We used RepeatFS to successfully visualize and replicate a variety of bioinformatics tasks consisting of over a million operations with no alteration to the original methods. RepeatFS correctly identified all software inconsistencies that resulted in replication differences.

RepeatFS is implemented in Python 3. Its source code and documentation are available at https//github.com/ToniWestbrook/repeatfs.

Supplementary data are available at Bioinformatics online.
Supplementary data are available at Bioinformatics online.
Hypoglycemia is a major barrier to optimal glycemic control in insulin-treated diabetes. Recent guidelines from the American Diabetes Association have subcategorized "non-severe" hypoglycemia into level 1 (<3.9 mmol/L) and 2 (<3 mmol/L) hypoglycemia. Gastric emptying of carbohydrate is a major determinant of postprandial glycemia but its role in hypoglycemia counter-regulation remains underappreciated. "Marked" hypoglycemia (~2.6 mmol/L) accelerates gastric emptying and increases carbohydrate absorption in health and type 1 diabetes, but the impact of "mild" hypoglycemia (3.0-3.9 mmol/L) is unknown.

To determine the effects of 2 levels of hypoglycemia, 2.6 mmol/L ("marked") and 3.6 mmol/L ("mild"), on gastric emptying in health.

Fourteen healthy male participants (mean age 32.9 ± 8.3 years; body mass index 24.5 ± 3.4 kg/m2) from the general community underwent measurement of gastric emptying of a radiolabeled solid meal (100 g beef) by scintigraphy over 120 minutes on 3 separate occasions, while blood glucose was maintained at either ~2.6 mmol/L, ~3.6 mmol/L, or ~6 mmol/L in random order from 15 minutes before until 60 minutes after meal ingestion using glucose-insulin clamp. Blood glucose was then maintained at 6 mmol/L from 60 to 120 minutes on all days.

Gastric emptying was accelerated during both mild (P = 0.011) and marked (P = 0.001) hypoglycemia when compared to euglycemia, and was more rapid during marked compared with mild hypoglycemia (P = 0.008). Hypoglycemia-induced gastric emptying acceleration during mild (r = 0.57, P = 0.030) and marked (r = 0.76, P = 0.0014) hypoglycemia was related to gastric emptying during euglycemia.

In health, acceleration of gastric emptying by insulin-induced hypoglycemia is dependent on the degree of hypoglycemia and baseline rate of emptying.
In health, acceleration of gastric emptying by insulin-induced hypoglycemia is dependent on the degree of hypoglycemia and baseline rate of emptying.
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