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Zinc Hydride Catalyzed Chemoselective Hydroboration of Isocyanates: Amide Bond Creation along with C=O Connect Cleavage.
In vivo tests showed a low inflammatory response, good cicatrization, and advanced resorption at 60 days of implantation, as indicated by histological images. Selleck K03861 It was evidenced that the covalent union between CS and GO increased biocompatibility and the degradation/resorption capacity, demonstrating tissue regeneration with typical characteristics and tiny remnants of implanted material surrounded by a type III collagen capsule. These results show the potential application of the new synthesized films, including the CS-GO compound, in tissue engineering.In this research, an electron beam (EB) butt-welded P91 steel plate (~9 mm thick) is selected to measure longitudinal residual stresses (acting in the welding direction) using a promising residual stress measurement technique - the contour method. The EB weld causes short length scale residual stresses within the narrow width of the fusion zone with steep stress gradients lateral to the weld line, which presents a new challenge for the residual stress measurements. The special measures were taken for all main steps of the technique to improve its the spatial resolution, thereby the short length scale residual stresses were captured. The success of the measurement is assessed by comparing the contour method result to the neutron diffraction result, and a good agreement were found in the results of both the techniques. These results also shows that the contour measurement results successfully captured the steep stress gradient on both sides of the weld centre-line (0 mm) with tensile stress peaks situated just 2.8 mm apart. It is one of the best resolutions in residual stress length-scale in this component achieved in contour measurements.Jute, the second most important natural fibre crop after cotton in the world. Bangladesh occupied the first position for jute fibre production and exportation after India among south-east Asian countries. Tossa jute is cultivated more (80-85%) here among the commercial cultivation of jute and allied fibre crops. It produces quality fibre but yield is low due to stress susceptibility compared to capsularis jute. The self-pollination nature and sexual incompatibility between two jute species (C. capsularis and C. olitorius) cause narrower genetic base and restrict genetic exchange. So, intra specific hybridization using diversified jute germplasms or genetic change will be the best option to the jute breeders for genetic improvement of existing cultivars. Hence, 20 tossa jute genotypes were investigated through field based morphological study (RCBD) and laboratory oriented anatomical study (CRD) for yield and yield attributing morpho-anatomical variability at BJRI during March, 2019 to July, 2020. Among 20 tossssa jute improvement.Bacteria transport through soil is a complex process particularly when the cells are released from solid manures and co-transported with particles. This study focuses on understanding of the Escherichia coli release from different particle fractions (0.25-, 0.5-, 1-, and 2-mm) of solid manure and evaluating different influent boundary conditions during cell release from manure and when a solid manure is applied to the soil. The 0.25-mm and 2-mm particle sizes resulted a greater cell release compared to 0.5-mm and 1-mm fractions (p less then 0.05). The shape and magnitude of the cell release curves (CRCs) from the original manure bulk were mainly influenced by the two 0.25-mm and 2-mm fractions, respectively. The arithmetic mean for normalizing the CRCs and the time variable- based normalized CRCs for the manure-treated soil were the robust variables in evaluation of the experimental data. However, a single maximum bacteria concentration could provide the realistic dataset for the modeling process. Evaluation of the root-mean-squared-error and Akaike criterion showed that the two- and three-parametric models are recommended for simulating the cell release from solid manure in comparison with one parametric models. This study also suggests considering separate microbial release evaluations, with regards to influent concentration, for manure and manure-treated soils to propose best management practices for controlling bacteria pollution. Further research will reveal the key roles of different woody components and soluble material ratios for the various solid manures in bacteria release.A quantitative structure-activity relationship (QSAR) study was conducted using nineteen previously synthesized, and tested 1-aryl-6-hydroxy-1,2,3,4-tetrahydroisoquinolines with proven in vitro activities against Plasmodium falciparum. In order to computationally design and screen potent antimalarial agents, these compounds with known biological activity ranging from 0.697 to 35.978 μM were geometry optimized at the B3LYP/6-311 + G(d,p) level of theory, using the Gaussian 09W software. To calculate the topological differences, the series of the nineteen compounds was superimposed and a hypermolecule obtained with s ¯ = 17 and 20 vertices. Other molecular descriptors were considered in order to build a highly predictive QSAR model. These include the minimal topological differences (MTD), LogP, two dimensional polarity surface area (TDPSA), dipole moment (μ), chemical hardness (η), electrophilicity (ω), potential energy (Ep), electrostatic energy (Eele) and number of rotatable bonds (NRB). By using a training set composed of 15 randomly selected compounds from this series, several QSAR equations were derived. The QSAR equations obtained were then used to attempt to predict the IC50 values of 4 remaining compounds in a test (or validation) set. Ten analogues were proposed by a fragment search of a fragment library containing the pharmacophore model of the active compounds contained in the training set. The most active proposed analogue showed a predicted activity within the lower micromolar range.Sale of controlled drugs without prescription is a burning issue in developing countries like Pakistan. Illicit sale practices lead towards drug abuse and misuse among youngsters and negatively impact the health of youth and economy of any country. Present study aims to highlight the illicit sale practices at community pharmacies/drug stores of Punjab, Pakistan. Study was conducted at community pharmacies/drug stores (n = 200) of Punjab, Pakistan. Sales men at pharmacies/drugs stores were interviewed and then their statements were cross verified by sending fake customers at their community pharmacies to check the extent of illicit sale practices by them. Gathered data was analyzed using SPPS-22. Out of 200 pharmacies, pharmacists were physically present at 5% of pharmacies (n = 200), rest of the 95% pharmacies (n = 190) were being run by non-qualified persons and were found to be engaged in illicit sale practices. Controlled drugs were being provided to customers without prescription, which is a dilemma and need to be addressed for effective policy making.
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