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To explore the potential precursors of rock instability, it is necessary to clarify the mechanism of micro-crack from fracturing to failure, which involves the evolution of fracture size, orientation, source model, and their relationships to the loading. The waveforms of acoustic emission (AE) recorded by the sensor network attached rock sample during laboratory tests provide a data basis for solving these problems, since these observations are directly related to the characteristics of the fracturing sources. Firstly, we investigated the source mechanism, looking at the rise angle and the average frequency (RA-AF) trends during five loading stages in a uniaxial compression test. Results show that the proportion of shear events significantly increases when approaching instability. Secondly, we calculated the moment tensor for each event, considering the uncertainties of P-wave polarity, azimuth, and the takeoff angles of the rays. Moment tensor solutions suggest that there are obviously more crack events than shear events in all loading stages. Moment tensor evolutions confirmed that the decreasing of isotropic component and the increment of double-couple can be used as precursors of rock fracturing development. Considering the limitations of these two methods, it is suggested that we should be concerned more about the proportions of individual failure components and their evolutions over time, instead of absolutely classifying the events into a certain source type.The purpose of the paper is to develop an efficient approach to fault-tolerant control for nonlinear systems of magnetic brakes. The challenging problems of accurate modeling, reliable fault detection and a control design able to compensate for potential sensor faults are addressed. The main idea here is to make use of the repetitive character of the control task and apply iterative learning control based on the observational data to accurately tune the system models for different states of the system. The proposed control scheme uses a learning controller built on a mixture of neural networks that estimate system responses for various operating points; it is then able to adapt to changing working conditions of the device. Then, using the tracking error norm as a sufficient statistic for detection of sensor fault, a simple thresholding technique is provided for verification of the hypothesis on abnormal sensor states. This also makes it possible to start the reconstruction of faulty sensor signals to properly compensate for the control of the system. The paper highlights the components of the complete iterative learning procedure including the system identification, fault detection and fault-tolerant control. Additionally, a series of experiments was conducted for the developed control strategy applied to a magnetic brake system to track the desired reference with the acceptable accuracy level, taking into account various fault scenarios.Euthanasia in rodents is an ongoing topic of debate due to concerns regarding the aversive nature of gases with anesthetic properties such as carbon dioxide (CO2) and isoflurane. The aim of this study was to expand upon previously published work evaluating the aversiveness of CO2 by introducing an isoflurane treatment group in parallel. Aversion was tested using a forced exposure setup and an aversion-avoidance setup. In the first part of the study, 12 naïve female Sprague-Dawley rats were exposed during four consecutive days, once to each of four treatments isoflurane, fox urine, oxygen, and CO2. In the second part of the study, 24 naïve female Sprague-Dawley rats and 12 rats from the first experiment were exposed to CO2, isoflurane, or both gases. In the forced exposure study, there were no significant differences between CO2 and isoflurane treatments except in line crosses. Overall, rats were more active in the isoflurane and CO2 treatments compared to the control groups, suggesting that isoflurane and CO2 are similarly aversive. In the aversion-avoidance study, rats previously exposed to isoflurane left the dark chamber significantly earlier compared to naïve rats during exposure to isoflurane. We also show that learned aversion to isoflurane is sustained for at least 15 days after initial exposure. Given this result, we suggest that CO2 is superior to isoflurane when euthanizing rodents with prior exposure to isoflurane. Overall, these results confirm previous studies which suggest that care should be taken when considering the serial use of isoflurane as an anesthetic.Iron (Fe) plays an essential role in many physiological processes. Hereditary hemochromatosis or frequent blood transfusions often cause iron overload (IO), which can lead to cardiomyopathy and arrhythmias; however, the underlying mechanism is not well defined. In the present study, we assess the hypothesis that IO promotes arrhythmias via reactive oxygen species (ROS) production, mitochondrial membrane potential (∆Ψm) depolarization, and disruption of cytosolic Ca dynamics. In ventricular myocytes isolated from wild type (WT) mice, both cytosolic and mitochondrial Fe levels were elevated following perfusion with the Fe3+/8-hydroxyquinoline (8-HQ) complex. IO promoted mitochondrial superoxide generation (measured using MitoSOX Red) and induced the depolarization of the ΔΨm (measured using tetramethylrhodamine methyl ester, TMRM) in a dose-dependent manner. read more IO significantly increased the rate of Ca wave (CaW) formation measured in isolated ventricular myocytes using Fluo-4. Furthermore, in ex-vivo Langendorff-perfused hearts, IO increased arrhythmia scores as evaluated by ECG recordings under programmed S1-S2 stimulation protocols. We also carried out similar experiments in cyclophilin D knockout (CypD KO) mice in which the mitochondrial permeability transition pore (mPTP) opening is impaired. While comparable cytosolic and mitochondrial Fe load, mitochondrial ROS production, and depolarization of the ∆Ψm were observed in ventricular myocytes isolated from both WT and CypD KO mice, the rate of CaW formation in isolated cells and the arrhythmia scores in ex-vivo hearts were significantly lower in CypD KO mice compared to those observed in WT mice under conditions of IO. The mPTP inhibitor cyclosporine A (CsA, 1 µM) also exhibited a protective effect. In conclusion, our results suggest that IO induces mitochondrial ROS generation and ∆Ψm depolarization, thus opening the mPTP, thereby promoting CaWs and cardiac arrhythmias. Conversely, the inhibition of mPTP ameliorates the proarrhythmic effects of IO.
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