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32 (p less then 0.0001) when comparing high versus low FT3/FT4 ratio. In the placebo arm, median OS was 3.3, 5.6 and 7.7 months, in the three subgroups. HR for OS was 0.47 (p less then 0.0001) when comparing intermediate versus low and 0.33 (p less then 0.0001) when comparing high versus low. FT3/FT4 ratio retained its association with OS in the multivariate model in both arms. Conclusions While rejecting the predictive effect of baseline FT3/FT4 ratio, present data strengthen the prognostic role of the ratio, pave the way for direct clinical application, underline the need for a better biological understanding and suggest possible therapeutic implications for thyroid hormones.Background Air pollution, which represents a major environmental risk to human health, comprises a complex mixture of compounds where only little is known about its specific toxicities. Objectives This study examined the specific toxicities associated with ambient air pollutant mixtures with respect to gas/particle partitioning, particulate matter (PM) size, pollutant polarity and bioaccessibility from PM, and evaluated the contribution of PAHs and their oxygenated and nitrated derivatives (OPAHs, NPAHs). Methods Air samples (gas phase, PM10 and size-segregated PM), were collected at urban (in winter and summer) and background (winter) sites in the Czech Republic. The total and bioaccessible concentrations were addressed using organic solvent extraction and simulated lung fluid extraction, respectively. Organic extracts were also further fractionated according to polarity. Aryl hydrocarbon receptor (AhR)-mediated activity, anti-/estrogenicity, anti-/androgenicity, thyroid receptor (TR)-mediated activity and can health risk assessment. Except of parent PAHs in some cases, the targeted compounds contributed to the detected effects mostly to a relatively low extent implying huge data gaps in terms of endocrine disruptive potencies of targeted substances and the significance of other polar compounds present in ambient air.Background Boredom proneness has been demonstrated as a salient vulnerability factor for problematic mobile phone use. However, the mediating and moderating mechanisms underlying this relationship are less investigated. In the current study, we constructed an integrative moderated mediation model to test the mediating role of depression and the moderating role of attentional control in the relationship between boredom proneness and problematic mobile phone use. Method A total of 1099 college students (Mage = 20.04; SD = 1.25) were recruited to fill out the questionnaires measuring boredom proneness, depression, problematic mobile phone use, and attentional control. Results Depression partially mediated the relationship between boredom proneness and problematic mobile phone use. Attentional control moderated the indirect relationship between boredom proneness and problematic mobile phone use through depression, with the indirect relationship being weaker for college students with higher levels of attentional control. Moreover, attentional control moderated the direct relationship between boredom proneness and problematic mobile phone use, in that this relationship was stronger for college students with higher levels of attentional control. Conclusions These findings illuminate the pathway through which boredom proneness is linked to problematic mobile phone use (i.e., mediation) and the condition on which the relationship between boredom proneness and problematic mobile phone use depends (i.e., moderation). More importantly, this study revealed the potential "double-edged sword" effect of attentional control. These findings have implications for early intervention and prevention of problematic mobile phone use in college students.Established qualitative analysis method for Chaigui granules based on UHPLC-Q-orbitrap-MS/MS and applied to its absorption properties studies. The LC-MS method was established to identify the structures of the components and metabolites. And then biosamples of rats after administration, e.g. find more intestinal solution, serum and brain microdialysate, were detected in rats with same method. Xcalibur 3.2 software was used for mass spectrum analysis and identification. Compound discover 3.0 was used for metabolite analysis. 95 chemical constituents were identified from Chaigui granules, including sesquiterpenes, flavonoids, lactones, tannins, organic acids, saponins and so on. 82 components and 11 metabolites were found in intestinal solution. 28 chemical constituents and 32 metabolites were found in serum. 15 chemical constituents were found in brain microdialysate. Vanillic acid, abiflorin, paeoniflorin, 4-hydroxybenzoic acid, lactiflorin, Z-butylidenephthalide, saikosaponin c, saikosaponin a, atractylenolide III, saikosaponin g, saikosaponin b1, sesquiterpenes, butylphthalide, saikosaponin d and glycyrrhetinic acid directly passed through the blood-brain barrier, which might be speculated that Chaigui granule plays an antidepressant role mainly through regulating brain central mechanism and endocrine mechanism, and so on. It is a systematically applicable approach for rapid identification and relative quantitation of Chaigui granules in vivo by UHPLC-Q-orbitrap-MS/MS, provides an important basis for the safety evaluation and rational clinical application of Chaigui granules.Owing to the promising photocatalytic performance, the sheet-like WO3 was modified by depositing nanostructured Co3O4 at the surface. The appearance of the varying dual absorption edges in the optical analysis exposed the composite nature of the synthesized materials. The structural analysis revealed the deposition of Co3O4 particles at the surface without altering the lattice of WO3 however, during the processing the cracking of disc was also evidenced. The FESEM and HRTEM analysis corroborated the uniform surface dispersion of Co3O4 nanoparticles. The co-existence of 2+ and 3+ oxidation states of Co in the deposited Co3O4 was examined by XPS analysis. The efficient trapping of excitons by Co3O4 surface entities was witnessed in the emission measurements whereas the same was authenticated by the photo-electrochemical chronopotentiometry. The Co3O4 loaded sheets exhibited substantially enhanced activity for the removal of 2,4,6-trichlorophenol as compared to pure WO3 in the complete spectrum and visible region of natural sunlight exposure.
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