Notes

α1-Antitrypsin takes away inflammation and also oxidative stress through curbing autophagy throughout bronchial asthma.
Red beet (
L.) is commercially grown in Punjab and Khyber Pakhtunkhwa (KPK) regions while cultivated as vegetable in Baluchistan and Sindh regions of Pakistan. It is well known for its health-promoting role in several clinical and pathologic outcome due to abundance of betalains and other bioactive compounds. The purpose of study was to interpret bioactivity of of
leaves (BvLM) and roots (BvRM) extracts for finding natural cure of neurodegenerative diseases (NDs).

BvLM and BvRM extracts were evaluated for phytochemical composition, antioxidant, anti-inflammatory and anticholinesterase potential using standard protocols with modifications.

Phytochemicals analysis of BvLM and BvRM extracts depicted the presence of flavonoids, phenols, alkaloids, saponins and glycosides. The IC
values for free radical scavenging activity for BvRM and BvLM showed that BvLM (DPPH 2.20±0.72μg/mL,




H


2




O


2



0.0519±1.02μg/mL) is melpful in preventing and treating neurodegenerative disorders (NDs). In consideration of multifactorial and complex etiology of NDs, BvLM and BvRM extracts would be apt candidates for development of therapeutic strategy for management of multiple cognitive disorders.The Bar-tailed Lark (Ammomanes cinctura) breeds in desert and semi-desert areas of the Saharo-Sindian region, from north-west Africa through the arid plains of the Arabian Peninsula to the Sind. Despite having a wide distribution, little information is available on the breeding ecology of this species. This study was conducted in a desert in the north of Saudi Arabia, where the daytime ambient temperature may exceed 40 °C. In contrast, the night ambient temperature may reach less than 10 °C in late spring and early summer. The objectives of this study were to collect some baseline data on some aspects of the breeding ecology of this species and to record the nest attendance behavior. The study found that Bar-tailed Larks preferred to nest under shrub trunks, which may camouflage both nests and incubating parents against predators and protect eggs, nestlings and incubating parents from hostile weather conditions. Moreover, nest attendance was high, as Bar-tailed Lark parents incubated their eggs 95.97 ± 2.62% over the entire day, and they seemed to maintain the eggs at temperatures around 23-33 °C. In addition, they incubated more at night than during the daytime. Temperatures under the shrubs at night fell below 21 °C, thus parents increased the nest attendance to warm the eggs and prevent the embryos from exposure to lethal temperatures.Snakebite being medical emergency and known cause for increased mortality needs assessment and treatment on high-priority bases, even in patients of snakebite who appear fine initially. The current retrospective study presents the snake bites in Saudi Arabia from 2015 to 2018 reported by General Administration of Statistics and Information, Ministry of Health, Kingdom of Saudi Arabia. The data presented in the current study, was extracted, analyzed, and reported after getting ethical approval from institutional committee. Totally, 14,679 cases of snakebites were reported during the four-year study period, with a higher prevalence in males (80%) in their productive age. Most patients were within the age group between 25 and 44 followed by 44 to 64 years. The majority of snakebite affected inhabitants were reported from farms of the rural areas, commonly during night hours of spring and summer seasons when snakes are very active. Only 36 (0.24%) patients out of 14,679 were reported dead and 14,643 (99.63%) were discharged after the treatment. Awareness among the general public should be encouraged and early diagnosis and usage of proper snake antivenoms could be life-saving. The delay in appropriate treatment can lead to significant morbidity and mortality.Queen mating frequency is an important reproductive trait of the western honeybee Apis mellifera. Yet, it demands more attention when investigated under extreme or confined ecosystems. Queen mating frequency of the Yemeni Honeybee A. m. jemenetica was estimated under Saudi Arabia desert conditions, Riyadh (24°71'36″N, 46°67'53″E). Mating of queens took place after 8-13 days from emergence. Duration of mating flight ranged between 26 and 39 min. Subsequently, six microsatellite loci were used to genotype queen's progeny (n = 30 workers/queen). The average number of drone alleles using workers genotypes ranged between 5.83 ± 0.31 and 6.33 ± 1.09. However, effective paternal allele number was extremely low and ranged between 3.35 ± 0.34 and 3.60 ± 0.40. This relatively low mating frequency of the Yemeni honeybee, A. m. jemenetica, might have striking effect on the overall colony survival. Providentially, this relatively low mating frequency does not impact colonial heterozygosity, shown in this study (0.66 ± 0.07-70 ± 0.04), adversely. These results may affect hive survivability and entails distinctive management practices under such conditions.
Type 2 diabetes (T2D) is a complex polygenic disease with unclear mechanisms. Clinical studies on the association of vitamin A with T2D in humans are still controversial. Herein, we aimed to investigate the plasma levels of vitamin A, predictor factors, and its correlations with clinical phenotypes in Emirati population. The effect of glucose-and lipid-lowering medications on vitamin A levels was also studied.

A cross-sectional cohort comprised 158 T2D-subjects and 90 healthy controls were recruited from the United Arab Emirates National Diabetes Study (UAEDIAB). All anthropometric, clinical, and biomedical measurements were collected. Plasma levels of vitamin A were determined using ELISA assay.

Levels of vitamin A were significantly lower in T2D-subjects compared to healthy control (p<0.01). Vitamin A levels were unaffected by gender base and inversely correlated with age, fasting blood glucose (FBG), glycated hemoglobin (HbA1c), waist circumference, triglycerides, and body mass index (BMI). Regression analysis revealed that HbA1c and age are predictors for vitamin A. Intake of glucose- or lipid-lowering medications showed no effect on vitamin A levels.

HbA1c and age are predictors for low levels of vitamin A among Emirati-T2D subjects. No influence of glucose and lipid-lowering medications on the plasma levels of vitamin A.
HbA1c and age are predictors for low levels of vitamin A among Emirati-T2D subjects. see more No influence of glucose and lipid-lowering medications on the plasma levels of vitamin A.
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