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5-100 ng mL-1) and low detection limits (0.09-0.14 ng mL-1). The method's accuracy ranged from 98% to 118%, with intra-day precision ranging from 1% to 10%. In contrast, inter-day precision ranged from 3% to 16%. Accuracy was also evaluated using independent urine samples, which ranged from 78% to 124% with corresponding relative standard deviations (1%-16%). Ultimately, DoCP was detected in two real samples at a concentration of 0.5-1.1 ng mL-1, and BEHP was detected at a concentration of 0.2-1.2 ng mL-1. Overall, the proposed SPME-UPLC-MS/MS method is reliable, accurate, and capable of simultaneously determining four OPFR metabolites in urine samples and screening them to assess exposure risk for humans.Near-infrared (NIR) calibration models are widely developed and routinely used for the prediction of physicochemical properties of samples. However, the main challenge with NIR models is that they are highly specific to the physical form of the samples. For example, a NIR calibration established for solid samples can usually not be used for the same samples in powdered form. Domain adaption (DA) techniques, such as domain invariant partial least-squares (di-PLS) regression, have recently appeared in the chemometric domain which allow adapting NIR calibrations for new sample-/instrument- or environment-associated conditions in a standard free manner. A practical use case of di-PLS can be assumed as the adaption of NIR calibration models to be used in different physical forms of samples. In this contribution we show, for the first time, application of di-PLS regression analysis for adapting a near-infrared (NIR) calibration for solid rice kernels to be used on powdered rice flour without the need for new reference measurements for the latter. di-PLS is a domain adaption technique that removes the differences between different but related data sources (i.e. domains) to reach generalized models. The study found that di-PLS allowed a direct adaption of calibration based on solid rice kernels to be used on powdered rice flour without requiring any reference protein measurements for the latter. Our results suggest that DA tools, such as di-PLS, can support a wider usage of chemometric calibrations especially when models need to be adapted to different physical forms of the same samples.The nickel organic framework capped with polyvinylpyrrolidone was prepared and synergistically immobilized onto porous silica surface as the mixed-mode stationary phase for high-performance liquid chromatography. Here, polyvinylpyrrolidone firstly was chosen as functional molecules to change morphology and size of the metal organic framework. The silica microspheres were then modified by them via a simple bonding method rather than in-situ growth method with the aid of electrostatic interaction commonly used before. The stationary phase showed flexible selectivity for separation of both hydrophilic and hydrophobic compounds, especially for hydrophilic compounds such as carbohydrates, alkaloids and sulfonamides etc. The chromatographic behaviors were evaluated by investigating various factors, and a typical mixed-mode retention feature of the column was observed. The composites could be prepared repetitively, and relative standard deviations of retention time of objective compounds among different batches were less than 1.75%. It also showed excellent chromatographic reproducibility, stability and potentiality for application in real samples. In short, the composites can be used for a feasible option for analysis of multiple compounds as the mixed-mode stationary phase and it provides a general approach for preparing MOFs-based composites by changing morphology and size of MOFs.The superior supramolecular recognition ability of macrocyclic compounds will enhance the sensitivity and selectivity of electrochemical detection, which has a great application potential in electrochemical sensing. Herein, we developed a novel electrochemical aptasensor based on the specific host-guest interactions between cucurbit [7]uril and ferrocene (Fc) for capture, determination and release of exosomes. Macrocyclic compounds, cucurbit [7]uril is modified on the surface of the gold nanoparticles composed electrode by self-assembling. CD63 aptamer linked ferrocene is introduced into this platform to capture exosomes specifically by CD63 protein on the exosomes. The dual specificity of macrocyclic compounds and aptamers enables highly selective and sensitive electrochemical detection of exosomes. The limit of detection (LOD) was 482 particles μL-1. In addition, the captured exosomes could be released on demand in a very mild manner through aminoferrocene (NH2-Fc) because of its higher affinity to cucurbit [7]uril. The proposed electrochemical aptasensor showed good performance in detecting exosomes even in plasma samples, thus demonstrating its great potential in early clinical diagnosis. Simultaneously, exosomes could be released undamaged by this protocol, exhibiting good applicability in comprehensive studies of exosomes. Moreover, this strategy can be applied to other target biomolecules by changing the recognition pairs.The measurement of iodine in table salt is vital for the successful implementation of the universal salt iodization (USI) program to fight iodine deficiency disorders (IDDs). This paper presents a smartphone-based optical transduction system for iodine measurement in table salt. The method was based on the response in the blue color space generated by the complex formed between the starch/iodide reagent and iodate in the salt sample. find more The parameters for the color reaction and for the image capture affected the response and were optimized. A matrix effect caused by NaCl was observed and was eliminated through matrix matching by incorporating NaCl in the standard solutions. The optimized method yielded a highly linear response to iodate concentrations ranging from 10 to 160 mg kg-1 (r = 0.9993) with a limit of detection of 2.8 mg kg-1. The method exhibited good accuracy and precision, based on AOAC standards. It produced results that were in agreement with those obtained using the reference method at the 95% confidence level.
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