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Background The endogenous allocation of spatial attention to selected environmental stimuli is controlled by prefrontal (frontal eye fields [FEFs]) and parietal (superior parietal lobe [SPL] and intraparietal sulcus [IPS]) regions belonging to the dorsal attention network (DAN) with a subdivision in subsystems devoted to reorienting (or shifting) of attention between locations (SPL) or maintaining attention at contralateral versus ipsilateral locations (ventral IPS [vIPS]). Although previous studies suggested a leading role of prefrontal regions over parietal sites in orienting attention, the spectral signature of communication flow within the DAN for different attention processes is still debated. Methods We used the directed transfer function (DTF) on magnetoencephalography (MEG) data to examine the causal interaction between prefrontal and parietal regions of the DAN when subjects shifted versus maintained attention to a stream of cued visual stimuli. Results In the beta band, we found that shift versus sten frontal and parietal regions belonging to the dorsal attention network supporting spatial reorienting response.Background Female genital cutting (FGC) is a form of gender-based violence with obstetrical and gynecological complications that require recognition and care. Data suggest that United States' physicians are not prepared to care for those who have been affected by this practice. This study evaluated the knowledge and practices of United States' obstetricians and gynecologists to care for patients who have undergone FGC. Materials and Methods This was a cross-sectional confidential survey distributed electronically to a sample of clinically active members of the American College of Obstetricians and Gynecologists. The survey consisted of questions characterizing care of patients who had undergone FGC and barriers to optimal support. Results Five hundred forty-eight participants representing a wide range of years in practice, geographical locations, subspecializations, and patient demographics participated. Sixty-six percent of participants had cared for patients who had undergone FGC. Participants' description of their patient population racial/ethnic composition did not correlate with likelihood of treating this patient population. Forty percent of participants reported some form of education about FGC, more often among women, younger physicians, and those in practice for fewer years. Thirty-one percent of participants were comfortable counseling about and 20% were comfortable performing deinfibulation; these percentages were higher among those who had received education or had recently cared for an affected patient. Participants reported insufficient training as the largest barrier to providing care to women. Conclusions While most physicians in this national cohort had cared for women who had undergone cutting, a minority had any form of education. However, prior education correlated with indicators of improved care. Physicians require additional guidance in treating this important and growing patient population.Therapeutic options for the treatment of infections by multidrug-resistant Acinetobacter baumannii strains are often limited. Minocycline (MIN) is an old antibiotic, with excellent activity against A. baumannii isolates, which can be administered orally. Currently, there is no single criterion regarding the breakpoints for MIN and A. baumannii. The activity of MIN was examined against a collection of A. check details baumannii isolates recovered from 15 hospitals of 6 countries of South America. A review of the literature was also performed. In our series and most of the studies, the percentages of MIN susceptible isolates exceeded 50%, regardless of the breakpoints utilized (4-2 or 1 μg/mL). However, a greater number of isolates not harboring Tet B were considered resistant with the breakpoints of 1 or 2 μg/mL, whereas isolates with tet(B) genes were still detected with minimum inhibitory concentration below all breakpoints considered. Tetracycline susceptibility may be used as a screening to discriminate the populations with and without acquired resistance mechanisms to MIN. In this study, MIN-resistant subpopulations were found in isolates harboring Tet B, with MIC ≤1 μg/mL, and their frequency increased after incubation with MIN. These subpopulations were not detected in isolates not harboring Tet B. The clinical correlation of these subpopulations should be evaluated in future studies.Motivation Mechanisms underlying the variation in the appearance of electroencephalogram (EEG) over human head are not well characterized. We hypothesized that spatial variation of the EEG, being ultimately linked to variations in cortical neurobiology, was dependent on cortical connectivity patterns. Specifically, we explored the relationship of resting-state functional connectivity derived from intracranial EEG (iEEG) data in seven (N = 7) human epilepsy patients with the intrinsic dynamic variability of the local iEEG. We asked whether primary and association brain areas over the lateral frontal lobe-due to their sharply different connectivity patterns-were thus dissociable in "EEG space." Methods Functional connectivity between pairs of subdural grid electrodes was averaged to yield an electrode connectivity (EC) whose time-average yielded mean electrode connectivity (mEC), compared with that electrode's time-averaged sample entropy (SE; mean electrode sample entropy, mESE). Results We found that mEC and and the connectivity of that local cortical region to the rest of the brain. Due to the differing connectivities of primary and association motor areas, our methods identify new differences in the EEG arising from those respective brain areas. Our work demonstrates that aspects of brain dynamics (i.e., EEG entropy) may be understood in terms of brain architecture (i.e., functional connectivity) and vice versa.Background The lack of incentives has been described as the rate-limiting step for data sharing. Currently, the evaluation of scientific productivity by academic institutions and funders has been heavily reliant upon the number of publications and citations, raising questions about the adequacy of such mechanisms to reward data generation and sharing. This article provides a systematic review of the current and proposed incentive mechanisms for researchers in biomedical sciences and discusses their strengths and weaknesses. Methods PubMed, Web of Science, and Google Scholar were queried for original research articles, editorials, and opinion articles on incentives for data sharing. Articles were included if they discussed incentive mechanisms for data sharing, were applicable to biomedical sciences, and were written in English. Results Although coauthorship in return for the sharing of data is common, this might be incompatible with authorship guidelines and raise concerns over the ability of secondary analysts to contest the proposed research methods or conclusions that are drawn.
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