Notes

Computational Look at Bioactive Substances through Colocasia affinis Schott as a Story EGFR Chemical with regard to Cancers Treatment.
40 (0.28-0.59), 0.16 (0.10-0.24); 0.32 (0.22-0.47), 0.18 (0.11-0.20); 0.33 (0.21-0.52), 0.18 (0.11-0.30); 0.59 (0.37-0.9), 0.54 (0.38-0.78), respectively]. Conclusion The worker-occupation fit and different types of fit, including characteristic fit, need supply fit, and demand ability fit, could be associated with the occupational stress.Objective To establish the Core Occupational Stress Scale (COSS) norm values for manufacturing and medical workers. Methods A total of 10 316 manufacturing workers of 20 companies from 7 provincial capital cities and 5 031 medical workers of 19 hospitals from 4 provincial capital cities were investigated using a stratified sampling method. Questionnaire information including occupational stress was collected. Norms of mean, percentile and T scores were calculated for COSS total and sub-dimension scores by different demographic characteristics. Based on the normal distribution, cut points of x¯+0.5s, x¯+s, x¯+1.5s of COSS total scores were calculated to classify the degree of occupational stress. Results The COSS total scores were (45.48±8.16) and (45.71±8.46). LY3039478 The 50th percentiles were both 46, and T score ranges were (15-92) and (16-91), respectively, for manufacturing and medical workers. When the total score was58 for medical workers, occupational stress would be classified into none, mild, moderate, and severe levels. Conclusion Compatible with the national condition of China, as well as the principles of psychological measurement, these norm values for manufacturing and medical workers could provide theoretical support and practical guideline on occupational mental health promotion.Objective To develop the Core Occupational Stress Scale (COSS) for key occupational populations, and to assess the reliability and validity of COSS in China. Methods According to the literature review, in-depth interview and expert evaluation, the item pool of COSS was established. A total of 20 981 employees (3 703 employees from 2018 and 17 178 employees from 2019) of manufacturing, medical, and traffic polices, etc. from Beijing, Tianjin, Shanghai, Chongqing, Jiangsu, Shandong, Zhejiang, Hunan, Guangdong and Hubei were investigated using convenient sampling of those participating in general or occupational health examination of the day. Item differential test and exploratory factor analysis (EFA) were used to screen items from the item pool; confirmatory factor analysis (CFA) was used to test structure validity; criterion and convergent validity were tested by Pearson correlation. Cronbach's α coefficient was used to test the reliability of the scale. Results The EFA suggested a four-factor structure for a 17-item version of COSS, which were social support, organization and reward, demand and effort, and control. It explained 62.06% of the total variance and factor loadings ranged from 0.447 to 0.918. The CFA confirmed the hypothesized four-factor model (GFI=0.904, CFI=0.912, RMSEA=0.079). The COSS scores were positively correlated with burnout, depressive symptoms, and effort-reward imbalance scores with r ranging from 0.357 to 0.567 (P less then 0.05). The total COSS and each dimension of Cronbach's α coefficients were 0.772-0.896. Conclusions The COSS has good reliability and validity and can be used as an occupation stress assessment for occupational populations in China.In 2014, Joint United Nations Programme on HIV/AIDS (UNAIDS) put forward the goal of ending HIV epidemic by 2030 at the International AIDS Conference and proposed the strategic goal of achieving "three 90%" by 2020. This year is the closing year of this strategic goal, and all regions have begun to evaluate the progress of implementing the goal. This article discussed the progress of the implementation of the "three 90%", and scientifically interpreted the strategic goal. It is proposed that the goal is a relative and dynamic concept, and only if we sieze the opportunity to achieve the strategic goal and continuously enhance comprehensive prevention and control, can the HIV epidemic be better controlled.Occupational stress is one of the major occupational health problems in industrialized countries. In Europe, the United States, Japan, and other countries, occupational stress has been included in the prevention and control of occupational hazards in the workplace. This problem has also become a major risk factor affecting the physical and mental health of the working population in China. Over the last three decades, China had carried out a lot of research on occupational stress and made significant progress, but there is still a big gap between China and industrialized countries in terms of theoretical research on occupational stress, development of measurement tools, research topics and methods, formulation of regulations and standards, and practice of prevention and control. Articles in this key issue report the research on the core scale of occupational stress measurement for the Chinese working population, the scale scoring norm of manufacturing and medical personnel, the research on the relationship between positive psychology variables, and occupational stress and its role in the relationship between occupational stress and health outcomes.
Nephrotic syndrome (NS) is a common renal disorder in children attributed to podocyte injury. However, children with the same diagnosis have markedly variable treatment responses, clinical courses, and outcomes, suggesting molecular heterogeneity.

This study aimed to explore the molecular responses of podocytes to nephrotic plasma to identify specific genes and signaling pathways differentiating various clinical NS groups as well as biological processes that drive injury in normal podocytes.

Transcriptome profiles from immortalized human podocyte cell line exposed to the plasma of 8 subjects (steroid-sensitive nephrotic syndrome [SSNS], n = 4; steroid-resistant nephrotic syndrome [SRNS], n = 2; and healthy adult individuals [control], n = 2) were generated using microarray analysis.

Unsupervised hierarchical clustering of global gene expression data was broadly correlated with the clinical classification of NS. Differential gene expression (DGE) analysis of diseased groups (SSNS or SRNS) versus healthy controls identified 105 genes (58 upregulated, 47 downregulated) in SSNS and 139 genes (78 upregulated, 61 downregulated) in SRNS with 55 common to SSNS and SRNS, while the rest were unique (50 in SSNS, 84 genes in SRNS).
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