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Seven studies concerning the effects of alternate day fasting (ADF) on weight loss and diabetic parameters were analyzed. All of them have shown the effects of ADF on weight loss and slight improvement in diabetic parameters. For time-restricted feeding (TRF), a significant improvement in the HOMA-IR index was observed in 2 studies. One study saw an increase in fasting glucose. An analysis of 2 studies using a complete alternate day fasting (CADF) was performed. One study showed decrease in fasting glucose and insulin, and in one a decrease in glycosylated hemoglobin (HbA1c) was observed.

Different types of intermittent fasting reduce body weight and reduce diabetes parameters such as fasting glucose, fasting insulin, HOMA-IR index, and glycated hemoglobin (HbA1c).
Different types of intermittent fasting reduce body weight and reduce diabetes parameters such as fasting glucose, fasting insulin, HOMA-IR index, and glycated hemoglobin (HbA1c).
This study represents a first attempt to explore the typology of female adults from a large non-clinical sample based on healthy orthorexia (HO) and pathological orthorexia (orthorexia nervosa, ON).

1245 female adults (Mage = 38.04, SD = 9.73) completed a set of questionnaires assessing orthorexic behaviors, intuitive eating, self-esteem, perceived social support as well as eating disorders, depressive and anxiety symptoms.

Cluster analysis based on HO and ON scores yielded 4 distinct groups "Healthy orthorexia cluster" (HO), "Orthorexia Nervosa cluster" (ON), "Low Orthorexia cluster" (LO) and "In-between Orthorexia cluster" (IBO). The HO and ON clusters represented individuals with, respectively, healthy and pathological interest in healthy diet. The LO cluster represented those with no particular interest in healthy eating and the IBO cluster showed that ON and HO behaviors can be associated in some individuals. Among all clusters, the ON cluster displayed highest levels of ED, anxiety and depressive symptoms. Inversely, the HO cluster displayed highest levels of intuitive eating, self-esteem and perceived social support.

Altogether, findings from this study support the bidimensional structure of orthorexic eating behavior and further suggest that ON and HO behaviors can be associated in some individuals. Our findings further provide evidence for the assumption that ON and HO could be seen, respectively, as maladaptive and protective eating behaviors.

V, descriptive study.
V, descriptive study.
Weight bias internalization (WBI) is associated with negative health consequences such as eating disorders and psychosocial problems in children. To date, it is unknown to what extent WBI considerably raises the risk of negative outcomes.

Analyses are based on cross-sectional data of 1,061 children (9-13years, M = 11, SD = 0.9; 52.1% female) who filled in the WBI scale (WBIS-C). First, ROC analyses were run to identify critical cut-off values of WBI (WBIS-C score) that identify those who are at higher risk for psychosocial problems or eating disorder symptoms (as reported by parents). Second, it was examined whether WBI is more sensitive than the relative weight status in that respect. Third, to confirm that the cut-off value is also accompanied by higher psychological strain, high- and low-risk groups were compared in terms of their self-reported depressive symptoms, anxious symptoms, body dissatisfaction, and self-esteem.

WBIS-C scores ≥ 1.55 were associated with a higher risk of disturbed eating behavior; for psychosocial problems, no cut-off score reached adequate sensitivity and specificity. Compared to relative weight status, WBI was better suited to detect disturbed eating behavior. Children with a WBIS-C score ≥ 1.55 also reported higher scores for both depressive and anxious symptoms, higher body dissatisfaction, and lower self-esteem.

The WBIS-C is suitable for identifying risk groups, and even low levels of WBI are accompanied by adverse mental health. Therefore, WBI is, beyond weight status, an important risk factor that should be considered in prevention and intervention.

Level III, cross-sectional analyses based on data taken from a well-designed, prospective cohort study.
Level III, cross-sectional analyses based on data taken from a well-designed, prospective cohort study.Cancer immunotherapy, which leverages features of the immune system to target neoplastic cells, has revolutionized the treatment of cancer. The use of these therapies has rapidly expanded in the past two decades. Immune checkpoint inhibitors represent one drug class within immunotherapy with its first agent FDA-approved in 2011. Immune checkpoint inhibitors act by disrupting inhibitory signals from neoplastic cells to immune effector cells, allowing activated T-cells to target these neoplastic cells. Unique adverse effects associated with immune checkpoint inhibitors are termed immune-related adverse effects (irAEs) and are usually immunostimulatory in nature. Almost all organ systems may be affected by irAEs including the dermatologic, gastrointestinal, pulmonary, endocrine, and cardiovascular systems. These effects range from mild to life-threatening, and their onset can be delayed several weeks or months. For mild irAEs, symptomatic care is usually sufficient. For higher grade irAEs, discontinuation of therapy and initiation of immunosuppressive therapy may be necessary. The management of patients with irAEs involves multidisciplinary care coordination with respect to the long-term goals the individual patient. Clinicians must be aware of the unique and sometimes fatal toxicologic profiles associated with immunotherapies to ensure prompt diagnosis and appropriate management.
Most available drugs used for management of hypertension have presented a plethora of challenges which genuinely called for development of therapies from natural sources.

This study investigated the effect of methanol extract of Adansonia digitata fruit (MEADF) pulp on N
-nitro-L-arginine methyl ester (L-NAME) induced hypertension in rats.

Fourty eight (48) wistar rats divided into six (6) groups (eight rats each) were employed. The induction of hypertension was achieved using L-NAME (40mg//kg body weight) by oral gavages. The induced rats were treated with MEADF pulp (200 and 400 mg/kg body weight) and Ramipril (10 mg/kg) and the remaining three groups serve as control. Methotrexate supplier Serum haemodynamic and biochemical modifiable parameters were determined using standard assay procedures RESULTS Administration of MEADF to the rats exerted a dose-dependent lowering effect on the elevated systolic blood pressure, diastolic blood pressure, mean arterial pressure and heart rate towards the normal physiological threshold.
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