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Hyperbilirubinemia is associated with protection against various oxidative stress-mediated diseases. We aimed to investigate the association between bilirubin and novel electrocardiography (ECG)-based ventricular repolarization parameters.
We enrolled 201 healthy men with mild hyperbilirubinemia (group 1) and 219 healthy men with normal bilirubin levels (group 2). The Tpeak-Tend (Tp-e) interval (defined as the interval from the peak of the T wave to the end of the T wave), corrected (c) Tp-e interval, QT interval, cQT interval, and Tp-e interval/QT interval ratio were measured from leads V5 and V6 with 20 mm/mV amplitude and 50 mm/second rate.
The Tp-e interval, cTp-e interval, and Tp-e interval/QT interval ratio were significantly lower in group 1 compared with group 2. The cTp-e interval showed a significant negative correlation with total bilirubin, conjugated bilirubin, and unconjugated bilirubin. The cTp-e interval (odds ratio [OR], 0.900; P =.002) and Tp-e interval/QT interval ratio (OR, 0.922; P =.04) were significantly associated with mild hyperbilirubinemia.
We showed the association of mild hyperbilirubinemia with decreased novel ECG-based ventricular repolarization parameters.
We showed the association of mild hyperbilirubinemia with decreased novel ECG-based ventricular repolarization parameters.Southern green stink bug, Nezara viridula (L.) and redbanded stink bug, Piezodorus guildinii (Westwood) are two of the most important seed sucking pests affecting Louisiana soybean production and rice stink bug, Oebalus pugnax (F.) is an important late season pest in Louisiana rice. Exploration of chemicals that exhibit attraction or repellent activities toward major stink bug species would be beneficial in developing push-pull strategies. Spinosad is a commercially available natural insecticide that may have arrestant, attractant, or phagostimulant properties against stink bugs. To test this, a series of laboratory experiments were conducted to investigate the tactile, olfactory, and feeding responses of these stink bugs toward two commercial spinosad products (Entrust and Tracer) and technical grade spinosad. In tactile assays, female and male redbanded stink bug were arrested by Entrust, Tracer, and technical grade spinosad, whereas only rice stink bug and southern green stink bug males were arrested by Entrust. Y-tube assays revealed no attraction to any of the products by either male or female rice stink bug, redbanded stink bug, or southern green stink bug. In paired (treated or untreated soybean seed) feeding preference experiments, southern green stink bug showed no preference for any treatment, whereas redbanded stink bug fed more on Entrust- and Tracer-treated seed. From these results, spinosad appears to have an arrestant and phagostimulant effect on redbanded stink bug in the laboratory.One of the key challenges many peer-to-peer mentoring programs face is the lack of high-quality mentor training. In order to address this issue, the BUILDing SCHOLARS (BUILD) program at The University of Texas at El Paso (UTEP) implements a structured peer mentor training and provides the training to BUILD fellows at UTEP for four academic years. This paper focuses on introducing the BUILD Peer Mentor Training (BPMT) model and investigates its impacts on students using program evaluation data. Our results reveal that BUILD peer mentors were satisfied with the BPMT and their relationships with the mentees. They also reported that the training greatly improved their problem solving and action planning skills, and slightly improved their communication skills and ability to assess a mentee's understanding. Finally, four practical recommendations are provided for institutions and programs that might be interested in implementing a similar peer mentor training.Early complications post hematopoietic stem cell transplantation (HSCT) such as sinusoidal obstruction syndrome (SOS) and graft versus host disease (GVHD) can be life threatening. Although several biomarkers have been identified to correlate with these complications and their response to treatment, these are yet to be used in clinical practice. Here, we evaluated circulating endothelial cells (CECs) (n = 26) and plasma biomarkers (ST2, REG3α, VCAM1, ICAM1, TIM3) (N = 210) at early time points, to determine their association with early complications post-HSCT. Elevated CEC counts at the end of conditioning was associated with GVHD, indicating endothelial damage during HSCT. Plasma levels of REG3α, VCAM1, ICAM1, and TIM3 on day 14 (D14) and D14 ICAM1 and D28 ST2 were significantly higher in patients with SOS and aGVHD, respectively. read more Upon sub-group analysis, D28 ST2, D14/D28 REG3α, and D14ICAM1 levels were significantly higher in patients with gastrointestinal GVHD, while D28ST2 was higher in those with skin/liver GVHD. High ST2 levels on D28 was significantly associated with non-relapse mortality (NRM) and overall survival. Our results suggest that elevated ST2 levels on D28 could predict the likelihood of developing aGVHD and could influence NRM and OS.DNA methylation plays an important role in both normal human development and risk of disease. The most utilized method of assessing DNA methylation uses BeadChips, generating an epigenome-wide "snapshot" of >450,000 observations (probe measurements) per assay. However, the reliability of each of these measurements is not equal, and little consideration is paid to consequences for research. We correlated repeat measurements of the same DNA samples using the Illumina HumanMethylation450K and the Infinium MethylationEPIC BeadChips in 350 blood DNA samples. Probes that were reliably measured were more heritable and showed consistent associations with environmental exposures, gene expression, and greater cross-tissue concordance. Unreliable probes were less replicable and generated an unknown volume of false negatives. This serves as a lesson for working with DNA methylation data, but the lessons are equally applicable to working with other data as we advance toward generating increasingly greater volumes of data, failure to document reliability risks harming reproducibility.
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