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We found that LH2 overexpression dramatically increases HNSCC cell migratory and invasive abilities in vitro and that LH2-driven changes in collagen cross-linking robustly induces metastasis in vivo. Specifically, the amount of LH2-mediated collagen cross-links increased significantly with PLOD2 overexpression, without affecting the total quantity of collagen cross-links. Conversely, LH2 knockdown significantly blunted HNSCC cells invasive capacity in vitro and metastatic potential in vivo. Thus, regardless of the total "quantity" of collagen crosslinks, it is the "quality" of these cross-links that is the key driver of HNSCC tumor metastatic dissemination. These data implicate LH2 as a key regulator of HNSCC tumor invasion and metastasis by modulating collagen cross-link quality and suggest that therapeutic strategies targeting LH2-mediated collagen cross-linking in the TME may be effective in controlling tumor progression and improving disease outcomes.Green vertical systems have advantages in terms of building energy performance, but their environmental impact should be assessed in comparison to un-vegetated constructive systems. The aim of this paper was to evaluate the environmental loads of a green façade, which was compared to other building exterior wall systems. A Life Cycle Analysis approach was used to compare the green façade with constructive solutions commonly applied for enhancing the thermal insulation properties of the building exterior walls. The green façade and the other constructive solutions were characterised by an equivalent thermal behaviour. A green façade system prototype, realised with vegetation climbing on a steel frame, was used for the study. The comparison was carried out with exterior walls using insulation materials as expanded polystyrene, expanded cork and wood fibre. A double wall with an un-ventilated air gap was used as well. this website On average, the best environmental performance was recorded for the wall using cork as insulating material and for the double wall. The results highlighted the environmental criticalities of the green façade as the system having an environmental load among the most burdensome. Different scenarios of green façade with the use of alternative constructive solutions were hypothesized and compared by the life cycle analysis and life cycle impact assessment. The study showed that the adoption of a wooden frame in place of the steel one, as plant supporting structure, reduces the carbon footprint of the green façade by 58%. The environmental comparison was carried out also considering non-vegetated constructive solutions having an equivalent sun shading effect on the wall. The analysis showed that the green façade has the best environmental performance when compared with sun shading systems in aluminium or PVC.Leachates and landfill gas (LFG) are the major problems for closed landfills (CL) and cause significant threats to receiving waterbody and ambient air quality. In this study, a field pilot-scale CL with ex situ nitritation/in situ denitritation process was constructed and operated continuously under wide temperature variations. The effect of low temperature on leachate treatment, and LFG content was studied. Results showed that the combined process can efficiently remove nitrogen and organic matters from leachate, and change LFG content under low-temperature condition. In the ex situ nitritaion, maximum removal efficiencies of ammonia and chemical oxygen demand (COD) were over 99% and 85%, respectively. The loading rate of nitrogen and COD reached 0.5 kg N m-3 d-1 and 0.7 kg COD m-3 d-1, respectively. The inhibitions of free ammonia (FA) and free nitrous acid (FNA), and low temperature were the key factors affecting nitritation. With recirculating nitrified leachate, total oxidized nitrogen (TON) was completely reduced, and the refuse decomposition was accelerated. Denitritation was the main reaction responsible in the CL. Additionally, methane content was observed lowly at non-inhibitory TON loading rate of 5.8 ± 3.7 g N ton-1 TS d-1. This decrease was not caused by the increased of TON loading, but a carbon source competition by denitrificans. The estimated COD consumption and methane reduction were 55.0 kg d-1 by TON reduction, and 20 m3 d-1, respectively. Hence, this study served a potential strategy for postclosure care of landfills under low temperature variation.
Recently, the COVID-19 epidemic has become more and more serious around the world, how to improve the image resolution of COVID-CT is a very important task. The network based on progressive upsampling for COVID-CT super-resolution increases the reconstruction error. This paper proposes a progressive back-projection network (PBPN) for COVID-CT super-resolution to solve this problem.
In this paper, we propose a progressive back-projection network (PBPN) for COVID-CT super-resolution. PBPN is divided into two stages, and each stage consists of back-projection, deep feature extraction and upscaling. We design an up-projection and down-projection residual module to minimize the reconstruction error and construct a residual attention module to extract deep features. In each stage, firstly, PBPN performs back-projection to extract shallow features by two up-projection and down-projection residual modules; then, PBPN extracts deep features from the shallow features by two residual attention modules; finally, PBPN upsamples the deep features through sub-pixel convolution.
The proposed method achieves the improvements of about 0.14~0.47dB/0.0012~0.0060 for×2 scale factor, 0.02~0.08dB/0.0024~0.0059 for×3 scale factor, and 0.08~0.41dB/ 0.0040~0.0147 for×4 scale factor than state-of-the-art methods (Bicubic, SRCNN, FSRCNN, VDSR, LapSRN, DRCN and DSRN) in terms of PSNR/SSIM on benchmark datasets.
The proposed mehtod obtains better performance for COVID-CT super-resolution and reconstructs high-quality high-resolution COVID-CT images that contain more details and edges.
The proposed mehtod obtains better performance for COVID-CT super-resolution and reconstructs high-quality high-resolution COVID-CT images that contain more details and edges.
Homepage: https://www.selleckchem.com/JAK.html
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