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Chemical substance Training contra Chemophobia.
Inhaled gene therapy poses a unique potential of curing chronic lung diseases, which are currently managed primarily by symptomatic treatments. However, it has been challenging to achieve therapeutically relevant gene transfer efficacy in the lung due to the presence of numerous biological delivery barriers. Here, we introduce a simple approach that overcomes both extracellular and cellular barriers to enhance gene transfer efficacy in the lung in vivo. FLT3-IN-3 inhibitor We endowed tetra(piperazino)fullerene epoxide (TPFE)-based nanoparticles with non-adhesive surface polyethylene glycol (PEG) coatings, thereby enabling the nanoparticles to cross the airway mucus gel layer and avoid phagocytic uptake by alveolar macrophages. In parallel, we utilized a hypotonic vehicle to facilitate endocytic uptake of the PEGylated nanoparticles by lung parenchymal cells via the osmotically driven regulatory volume decrease (RVD) mechanism. We demonstrate that this two-pronged delivery strategy provides safe, wide-spread and high-level transgene expression in the lungs of both healthy mice and mice with chronic lung diseases characterized by reinforced delivery barriers.We examine how immigrants' health insurance in the United States is shaped by institutional traits of the health care systems in their origin societies. Conditional on a wide range of individual, country-of-origin, state-level, and temporal controls, we find the affordability of health care back home helps explain immigrants' US health coverage. Specifically, low- and middle-income migrants from countries with less affordable health care are more likely to get private insurance once in the United States and, correspondingly, less likely to have public coverage, relative to migrants from countries with more affordable care. The relationship conforms to multiple hypotheses. As predicted by the institutional beliefs hypothesis, migrants from countries with less affordable care might anticipate equally expensive health services in the United States and, in turn, insure themselves against high medical bills. Likewise, as predicted by the endogenous preferences hypothesis, migrants from countries with less affordable care might be accustomed to paying more for health care and, in turn, be less reluctant to pay for private health insurance. Overall, the findings underscore the relevance of migrants' past health care experiences in their origin societies in informing their health insurance in the United States even years after migration.The study aims to examine the impact of the coronavirus disease-2019 (COVID-19) pandemic lockdown on weight, overweight and obesity, and identify factors associated with weight gain. At a safety net health system in Massachusetts, 11 534 adults were retrospectively followed within 3 months of the COVID-19 lockdown. Chi-square and 95% confidence intervals (CI) were reported for categorical and continues variables, respectively. Multivariate analyses were performed to identify factors associated with weight gain (≥0.01 kg and 5%). During the lockdown period, greater proportion of women gained weight compared to men (46.1% vs 40.6%, P  less then  .01). The obesity rate after the lockdown increased among women (40.7%-41.7, P  less then  .01) but decreased among men (39.6%-38.6, P  less then  .01) compared to before the lockdown. Post-lockdown obesity rates increased among Haitian (51.2%-55.0%, P  less then  .01) and Hispanic women (50.7%-51.8%, P  less then  .01). More than 5% weight gain was associated with 18 to 39 vs ≥60 years of age (OR = 1.45, 95% CI = 1.07, 1.97), food and housing insecurity (OR = 1.44, 95% CI = 1.05, 1.97) and tobacco use (OR = 1.38, 95% CI = 1.07, 1.78) among men; and 18 to 39 vs ≥60 years of age (OR = 1.55, 95% CI = 1.25, 1.91), Hispanics (OR = 1.25, 95% CI = 1.01, 1.54), Brazilians (OR = 1.22, 95% CI = 1.03, 1.45), and tobacco use (OR = 1.36, 95% CI = 1.10, 1.69) among women. During the COVID-19 lockdown, significant proportion of participants gained weight, but subgroup variations existed. Our study can inform healthcare professionals about the impact of the lockdown on unhealthy weight gain and identify vulnerable populations. Strategies are needed to combat unhealthy weight gain during and beyond the pandemic.Nucleophilic aromatic substitution has been highly para selective on a range of functionalized pentafluorobenzenes. Here, we demonstrate the utility of nucleophilic aromatic substitution chemistry for the preparation of fluorinated fluorescent low-molecular-weight organogels. The molecular design, synthesis and photophysical performance of a new class of thermoreversible and fluorescent low-molecular-weight organogels from para-alkoxy-functionalized fluorinated terphenyls are described. Both CuI-catalyzed decarboxylative cross-coupling and nucleophilic aromatic substitution chemistry were used for the preparation of those highly fluorinated gelators in high yields and excellent purity via simple filtration, from the corresponding potassium fluorobenzoate salts and aryl iodides. Various fluorinated symmetrical and asymmetrical para terphenyls were prepared with various para terminal alkoxy tails. Those fluorinated terphenyls were characterized using X-ray crystallography, differential scanning calorimetry, Fourier-transform infrared spectroscopy, as well as 1 H, 13 C, and 19 F nuclear magnetic resonance. UV-visible light absorbance and emission spectra of those new materials displayed a solvatochromic and solvatofluorochromic behaviour, respectively. Self-assembly of the produced fluorinated terphenyls occurred via cooperative π-π stacking and van der Waals interactions, which resulted in gelating various organic solvents. Scanning electron microscopy displayed the formation of fibre-like nanostructures. The cytotoxicity of some selected fluorinated symmetrical and asymmetrical para terphenyls was explored.
Little is known about the nutritional care provided to patients who develop hospital acquired malnutrition (HAM). The present study aimed to describe the quality of nutritional care provided to patients who developed HAM and determine whether this differed by length of stay (LOS).

A retrospective medical records audit was conducted on adults with LOS >14days across five Australian public hospitals from July 2015 to January 2019 who were clinically assessed to have HAM. Descriptors and nutrition-related care data were sourced. Descriptive statistics were conducted. Chi-squared and t-tests were used to compare patient data by LOS ≤ or >50days.

Eligible patients (n=208) were 64% male, with median (range) LOS of 51 (15-354)days, body mass index=26.8±6.2kg m
and mean±SD age of 65±17years. Malnutrition screening was first completed a median (range) of 0 (0-31) days after admission, with weekly screening conducted on 29% of patients. Mean (range) time to initial dietitian assessment was 9 (0-87)days and 27 (2-173) days until malnutrition diagnosis.
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