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Eight patients (62%) completed treatment. All completers were in full remission after treatment, with BMI ≥18.5kg/m
and ED psychopathology within one standard deviation of the community mean. Improvements occurred after introducing RO DBT, not during baseline.
Participants were female with mild to moderate AN, limiting generalizability to severe AN or males.
The study provides preliminary support for using RO DBT in adult outpatients with AN and overcontrol. Further studies should replicate these findings.
The study provides preliminary support for using RO DBT in adult outpatients with AN and overcontrol. Further studies should replicate these findings.The electronic structure of GaN and GaNZn was investigated by electron energy loss spectroscopy and first-principles calculations. In the low-loss spectrum, the interband transitions are assigned to the observed energy loss peaks. After Zn doping, impurity levels are introduced to the density of states and hybrid orbitals of N 2p and Zn 3d are formed around the Fermi level. In the nitrogen K-edge, an additional peak was observed due to the formation of donor defect states. A core-hole effect is believed to be significant for simulation of the N K-edge for both GaN and GaNZn.The effects of external stress on the precipitation of T1 precipitates and mechanical properties of creep-aged Al-Cu-Li-Ag alloys are investigated. Promotion mechanisms of external stress to the precipitation of T1 precipitates are discussed. It is found that external stress significantly promotes the precipitation and improves the distribution of the T1 precipitates in the creep-aged alloys. There is a threshold stress, close to the yield stress, that has only a limited promotion effect on the precipitation of T1 precipitates. The external stress below and above the threshold stress promotes the precipitation of T1 precipitates by two different mechanisms. One is the promotion mechanism of lattice distortion produced by the elastic stress. Another is the promotion mechanism of multiplication of dislocations produced by the plastic stress. Both elastic and plastic external stress can synergistically improve the strength and ductility. Especially, the plastic external stress resulted in the best improvement to ductility of creep-aged alloys. Hence, the creep ageing with plastic external stress is an alternative method to synergistically improve the strength and ductility of Al-Cu-Li-Ag alloys. However, it is necessary to avoid using excessive plastic stress for the creep ageing because it may cause creep damage and degrade its mechanical properties.The morphology and surface characteristics of the powdery mildew Erysiphe australiana growing on crape myrtle leaves were observed with field emission scanning electron microscopy. The powdery mildew infection caused distortion and withering of the leaves, and nearly all external parts such as flowers, petioles, and branches were covered by the whitish colonies. Hyphal proliferation was prevalent on the adaxial surface of the powdery mildew-infected leaves. Globose ascocarp initials with hyphal aggregations were frequently seen on the leaf surface. Collapsed conidia showed longitudinal striations or ridges on the surface and deep linear wrinkling. Foot-cells were straight and grew at right angles from the vegetative hyphae. The conidiophores had fragmented, cylindrical, non-chained conidia which were produced singly at the apex of the conidiophores. The germ tubes formed intercalary multi-lobed appressoria and the conidia produced filiform protrusions emerging from subterminal positions. This study visualized previously unknown structures of E. australiana such as the ascocarp initials, filiform protrusions on conidia, and multi-lobed appressoria on germ tubes. These observations will facilitate the identification and taxonomy of this fungus and its allied species.Drinking water exposure to microcystin-leucine-arginine (MC-LR), the most widely occurring cyanotoxins, poses a highly potential risk for human health. However, the health risk of MC-LR exposure at current guideline value in drinking water has not yet entirely evaluated. In the current study, we used 1H NMR-based metabolomics combined with targeted metabolic profiling by GC/LC-MS to explore the toxic effects of MC-LR exposure at environmentally relevant concentrations via drinking water in rats. The results revealed that multiple biological consequences of MC-LR exposure on host metabolism in rats. Both relatively low and high doses of MC-LR used here induced hepatic lipogenesis and inflammation. ZX703 While only relatively high dose MC-LR (10 μg/L) in drinking water caused more metabolic disorders including inhibition of gluconeogenesis and promotion of β-oxidation of fatty acid. Although the dose of 1.0 μg/L MC-LR is extremely low for rats, alterations of metabolic profiles were unexpectedly found in rat liver and serum, alarming potential health risk of MC-LR at the WHO guideline level.To investigate whether microcystin-LR (MC-LR) influences children's cognitive function and memory ability, we measured serum MC-LR and whole blood lead levels in 697 primary students, and collected their academic and neurobehavioral test scores. The median of serum MC-LR levels was 0.80 µg/L (the value below the limit of detection to 1.67 µg/L). The shapes of the associations of serum MC-LR levels (cut-point 0.95 µg/L) with scores on academic achievements, digit symbol substitution test and long-term memory test were parabolic curves. Logistic regression analysis showed that MC-LR at concentrations of 0.80-0.95 µg/L was associated with the increased probability of higher achievements on academic achievements [odds ratio (OR) = 2.20, 95% confidence interval (CI) 1.28-3.79], and also with scores on digit symbol substitution test (OR = 1.73, 95% CI 1.05-2.86), overall memory quotient (OR = 2.27, 95% CI 1.21-4.26), long-term memory (OR = 1.85, 95% CI 1.01-3.38) and short-term memory (OR = 2.13, 95% CI 1.14-3.98) after adjustment for confounding factors. Antagonism of MC-LR and lead on long-term memory was observed (synergism index = 0.15, 95% CI 0.03-0.74). In conclusion, serum MC-LR at concentrations of 0.80-0.95 µg/L was positively associated with higher scores on cognitive and neurobehavioral tests, and antagonism between MC-LR at concentrations of 0.80-1.67 µg/L and lead exposure was obviously observed on long-term memory in children. Concerning that MC-LR is a neurotoxin at high doses, our observation is interesting and need further investigation.
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