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Quick improvement involving difficulty with sleep introduction and getting up every day and daytime somnolence simply by mix treatments associated with suvorexant as well as ramelteon in postponed sleep-wake period disorder: in a situation series of about three sufferers.
In addition, dietary restrictions must be set to prevent disease progression and deterioration. learn more Dietary intake in hemodialysis patients must be carefully calculated based on their needs, with tight monitoring of their blood glucose. Protein intake in hemodialysis patients should be determined based on risk-to-benefit ratios. CONCLUSION Dietary requirements should be individualized based on the patient's disease severity and progression. Assessment of the patient's previous and current diet, as well as matching it with their dietary requirements and preferences is crucial. Copyright© Bentham Science Publishers; For any queries, please email at [email protected] The study focused to systematically extract, summarize and analyse the data on the effect of lifestyle modification on leptin resistance and quality of life in metabolic syndrome. METHODS The systematic search was done using PubMed, Cochrane Database, EMBASE, Science Direct, CINAHL, Springer link, Web of Science from 2000-2018. English language articles, quantitative studies focusing on leptin resistance and quality of life were included. Random effect analysis was adopted to pool data and estimate 95% CI. The meta-analysis was done separately for leptin resistance and quality of life which included a total of 9 studies both RCTs and Non-RCTs. RESULTS The meta-analysis of RCTs reported insignificant effect of lifestyle modification on leptin resistance in metabolic syndrome when compared to comparison group [-5.94[-14.28, 2.41]. Two clinical trials showed a significant effect with pooled data [5.52[2.14, 8.91]. Meta-analysis of RCTs focusing on quality of life showed significant effect on mental component [4.89 [0.16, 9.62] of quality of life [2.36 [-3.67, 8.39] when compared to comparison group. CONCLUSION This meta-analysis suggested that lifestyle modification has potential to improve leptin resistance and mental component of quality of life in metabolic syndrome. However, more clearly defined studies are needed to come to a firmer conclusion. Copyright© Bentham Science Publishers; For any queries, please email at [email protected] There is a paucity of studies on health-related quality of life (HRQoL) and sarcopenic obesity (SO). OBJECTIVE We aimed to assess the potential association between SO and impaired HRQoL. METHODS The ORWELL 97 questionnaire was used to assess HRQoL and body composition was measured using a bioimpedance analyser (Tanita BC-418) in 130 patients with obesity, referred to the Nutritional and Weight Management outpatient clinic of Beirut Arab University in Lebanon. Participants were then categorized on the basis of the absence or presence of SO. RESULTS Sixty-four of the 130 participants met the criteria for SO (49.2%) and displayed significantly higher total ORWELL 97 scores than those in the group without SO (64.00 vs. 41.00, p=0.001), indicative of poorer HRQoL. Linear regression analysis showed that SO was associated with an increase in ORWELL 97 scores by nearly 24 units (β=24.35, 95% CI=11.45-37.26; p less then 0.0001). Moreover, the logistic regression analysis showed that SO increased the odds of clinically significant impairment of HRQoL (ORWELL 97 score ≥74.25) by nearly seven-fold (OR=7.37, 95% CI=1.92-28.39; p=0.004). CONCLUSION Our findings show that the presence of SO was associated with increased impairment in HRQoL that reaches clinical significance when compared to obesity only. Future studies are needed to clarify whether this may influence clinical outcomes. If this is shown to be the case, weight management programmes should incorporate additional strategies to improve HRQoL in individuals with SO. Copyright© Bentham Science Publishers; For any queries, please email at [email protected] Diabetic nephropathy can lead to renal diseases, and oxidative stress and mitochondrial dysfunction have critical roles in its development. OBJECTIVES In this study, the effect of syringic acid (SYR), natural phenolic acid on diabetic nephropathy and mitochondrial biogenesis were examined. METHODS Diabetes was induced in rats by injecting streptozotocin. SYR (25, 50 and 100 mg/kg/day) was orally administered for 6 weeks. SYR effects on factors, such as antioxidant activity and mRNA expression level of mitochondrial biogenesis indexes were evaluated. RESULTS In SYR-treated rats, blood glucose and ALP level were significantly reduced. SYR increased kidney GSH content in the diabetic group. Elevated renal catalase and superoxide dismutase activities in diabetic rats were restored to normal levels after treatment. The SYR significantly reduced renal TBARS level, which had increased in diabetic rats. This compound also significantly upregulated renal mRNA expression of PGC-1α and NRF-1, and increased mtDNA/nDNA ratio in diabetic rats. These values were reduced in non-treated diabetic group. The result show improvement of histopathological damages of kidney in SYR treated group in comparison with the diabetic group. CONCLUSION According to the results, SYR alters renal antioxidant defense mechanisms. Also, it could be considered as a novel approach by targeting mitochondria in renal diabetic complications. Copyright© Bentham Science Publishers; For any queries, please email at [email protected] Myocardial infarction (MI)，a kind of heart deficiency is a main cause of death and disability. Autophagy, a metabolic process for degradation of damaged proteins or organelles, is important for cardiac functions and regulated by several miRNAs including miRNA-101. This research was aim to investigate the effects of miR-101 in myocardial infarction-induced injury and the related mechanisms. METHODS MI model was induced by ligation of the left coronary artery. The in vitro model was established by hypoxia induced H9c2 cells (rat myocardial cells). The overexpression of miR-101 was achieved by transfection. The expression of associated proteins was analyzed by Western blotting. The level of miR-101 was analyzed by reverse transcription-polymerase chain reaction (RT-PCR). The target genes for miR-101 and the target sites were analyzed by TargetScan. RESULTS The results showed that miR-101 was decreased in MI mice (p less then 0.01). Autophagy and apoptosis were increased in MI-induced injury (in vivo) and in hypoxia treated myocardial cells (in vitro) (p less then 0.
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