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Growth and development of allelic elegance analysis to detect Mediterranean sea G6PD mutation and its particular connected gift of money together with normal eye-sight and/colorblindness loci with regard to Four years amid Egypt and Emirati families.
To evaluate the safety and efficacy of transepithelial accelerated corneal cross-linking (CXL) for advanced keratoconus eyes with maximum keratometry (Kmax) values >58 diopter (D).

Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China.

Prospective parallel control study.

Forty-one keratoconus eyes from 41 patients (mean age, 21.93+/-5.48 years) who underwent transepithelial accelerated CXL were included prospectively. The enrolled eyes were divided into two groups according to their Kmax values (group A, Kmax >=58.0 D; group B, Kmax <58.0 D). The examinations including assessment of uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), corneal topography, and corneal endothelial cell density count were conducted preoperatively, at 1 day, 1 month, 3 months, 6 months, and 1 year postoperatively.

No statistical difference was noted between the average UDVA and CDVA in both groups throughout the follow-up duration. At 1-year postoperative follow-up, the CDVA increased by >=2 lines in 45% (9/20) and 28.6% (6/21) eyes in groups A and B, respectively. The average preoperative Kmax in groups A and B were 62.51+/-3.34 D and 49.98+/-4.32 D, respectively, and that at postoperative 1-year follow-up were 61.94+/-4.11 D and 50.24+/-4.72 D, respectively. The Kmax values of 30% (6/20) eyes in group A and 4.8% (1/21) eyes in group B decreased by more than 1 D. Deduction of flat K, steep K, mean K, and Kmax showed no significant difference between the two groups at 1-year postoperative follow-up. Moreover, 20% (4/20) and 23.8% (5/21) of eyes in groups A and B, respectively, showed progress at postoperative 1-year follow-up.

Transepithelial accelerated CXL can safely treat advanced keratoconus eyes with Kmax values >=58.0 D with some extent of efficacy and has similar progressive rate as Kmax values < 58.0 D.
=58.0 D with some extent of efficacy and has similar progressive rate as Kmax values less then 58.0 D.
To evaluate the effectiveness and safety of a novel presbyopia-correcting intraocular lens (IOL) with a nondiffractive design, DFT015, compared with an aspheric monofocal IOL, SN60WF.

Nineteen investigational sites in four countries Australia, Canada, Spain, and the United Kingdom.

Prospective, randomized, parallel-group, controlled, assessor- and patient-masked clinical study.

Participants aged >=22 years with bilateral cataracts were randomized to DFT015 or SN60WF in a 54 ratio and masked until final postoperative follow-up at Month 6. The primary effectiveness objective was superiority of DFT015 over SN60WF in mean monocular photopic distance-corrected intermediate visual acuity (DCIVA) at Month 3. Secondary effectiveness objectives included noninferiority of DFT015 to SN60WF in mean monocular photopic best-corrected distance visual acuity (BCDVA), and superiority in mean monocular photopic distance-corrected near visual acuity (DCNVA) at Month 3. Visual disturbances were assessed at Month 6.

Two-hundred-and-eighty-two patients were randomized to DFT015 (n = 159) or SN60WF (n = 123). All effectiveness objectives were achieved at Month 3 in first eyes. For monocular photopic results in first eyes, DFT015 demonstrated superior mean DCIVA (LS Means of -0.139 logMAR in favor of DFT015, P < .001), noninferior mean BCDVA (97.5% upper confidence limit [UCL] of the difference was <0.1 logMAR) and superior mean DCNVA (95% UCL of the difference was <0.0 logMAR) compared with SN60WF at Month 6. DFT015 exhibited a similar visual disturbance profile to that of SN60WF.

DFT015 provides superior intermediate and near vision, and a similar visual disturbance profile, compared with an aspheric monofocal IOL.
DFT015 provides superior intermediate and near vision, and a similar visual disturbance profile, compared with an aspheric monofocal IOL.
Solitary fibrous tumor is a rare neoplasm of mesenchymal origin. It can arise in various locations, most commonly in the pleura. It encompasses a heterogeneous group of histological patterns with different biological behavior. In some cases, metastases occur, sometimes years after the initial diagnosis. We report a case of metastatic meningeal hemangiopericytoma, also called solitary fibrous tumor of the dura, exhibiting liver metastases and muscle metastases 5 years after resection and adjuvant radiotherapy of the primary tumor.
Solitary fibrous tumor is a rare neoplasm of mesenchymal origin. It can arise in various locations, most commonly in the pleura. It encompasses a heterogeneous group of histological patterns with different biological behavior. In some cases, metastases occur, sometimes years after the initial diagnosis. We report a case of metastatic meningeal hemangiopericytoma, also called solitary fibrous tumor of the dura, exhibiting liver metastases and muscle metastases 5 years after resection and adjuvant radiotherapy of the primary tumor.
The purpose of the present study was to evaluate associations between changes in segmental vertebral coronal angulation (screw angulation) and overall height after anterior spinal growth tethering for the treatment of idiopathic scoliosis and to compare the rates of coronal angulation change using the preoperative Sanders stage.

Patients with idiopathic scoliosis who underwent anterior spinal growth tethering between 2012 and 2016 and had >=2 years of follow-up were retrospectively studied. We calculated each segment's screw angulation rate of change (degrees/month) and each patient's height velocity (cm/month) between each of the visits (3 to 12 visits/patient) and divided the visits into 4 groups by postoperative duration (<1 year, 1 to 2 years, >2 to 3 years, >3 years). Patients were divided into 2 groups according to the preoperative Sanders stage. Generalized estimating equations and repeated-measures correlation were utilized for analyses with non-independent samples.

We analyzed 23 pa. See Instructions for Authors for a complete description of levels of evidence.
To describe a term newborn with acquired severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and multisystem involvement including seizures associated to ischemic lesions in the brain.

Coronavirus disease 2019 (COVID-19) is predominantly a respiratory infection, but it may affect many other systems. Most pediatric COVID-19 cases range from asymptomatic to mild-moderate disease. click here There are no specific clinical signs described for neonatal COVID-19 infections. In children, severe central nervous system compromise has been rarely reported.

We describe a 17-day-old newborn who acquired a SARS-CoV-2 infection in a family meeting that was admitted for fever, seizures and lethargy and in whom consumption coagulopathy, ischemic lesions in the brain and cardiac involvement were documented.

SARS-CoV-2 neonatal infection can be associated with multi-organic involvement. In our patient, significant central nervous system compromise associated to ischemic lesions and laboratory findings of consumption coagulopathy were found.
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