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f the critical undrilled thickness.The existing multi-sensor cluster acoustic emission (AE) source localization method has good positioning performance, but the parallel assumption in this method could cause positioning error. This paper focused on the analysis of the positioning error of multi-sensor cluster methods with sensor arrangements of isosceles right-angled triangle and triangular pyramid. Meanwhile, two and three-dimensional amendment algorithms for the two sensor arrangements were proposed. Pencil lead break experiments and numerical examples were used to verify the rationality of error source analysis and the accuracy of the amendment algorithms. Results show that the multi-sensor cluster methods can only accurately locate the AE sources in special positions, such as the AE sources satisfying θi = π/4 in the multi-sensor cluster method with a sensor arrangement of isosceles right-angled triangle and the AE sources satisfying cosθij=3/3 in the multi-sensor cluster method with a sensor arrangement of triangular pyramid. The results of pencil lead break experiment show that the two-dimensional amendment algorithm can accurately locate the AE sources in two-dimensional isotropic structure. For the two-dimensional anisotropic structure, the positioning result of the two-dimensional amendment algorithm is 27.8% higher than that of the multi-sensor cluster method with a sensor arrangement of isosceles right-angled triangle. The results of numerical examples show that the positioning errors of the multi-sensor cluster method with a sensor arrangement of triangular pyramid and the three-dimensional amendment algorithm are 24.6 mm and 0, respectively. Due to the correction of the positioning error caused by the parallel assumption, the latter has better positioning performance. Therefore, the amendment algorithms of the multi-sensor cluster methods have certain engineering application value in AE monitoring of two and three-dimensional structures.
Shenmai Injection (SMI) has been widely used in the treatment of cardiovascular diseases and can reduce side effects when combined with chemotherapy drugs. However, the potential protective mechanism of SMI on the cardiotoxicity caused by anthracyclines has not been clear.

We used network pharmacology methods to collect the compound components in SMI and myocardial injury targets, constructed a 'drug-disease' target interaction network relationship diagram, and screened the core targets to predict the potential mechanism of SMI in treating cardiotoxicity of anthracyclines. In addition, the rat model of doxorubicin cardiotoxicity was induced by injecting doxorubicin through the tail vein. The rats were randomized in the model group, miR-30a agomir group, SMI low-dose group, SMI high-dose group，and the control group. The cardiac ultrasound was used to evaluate the structure and function of the rat heart. HE staining was used to observe the pathological changes of the rat myocardium. Transmission electron mie autophagy by regulating the expression of miR-30a/Beclin 1 and alleviate the myocardial injury induced by doxorubicin.
SMI has the characteristics of multi-component, multi-target, and multi-pathway. It can inhibit myocardial excessive autophagy by regulating the expression of miR-30a/Beclin 1 and alleviate the myocardial injury induced by doxorubicin.
The current study was to evaluate the association of Etoricoxib treatment and incident hypoxia among type-B aortic dissection (AD) patients undergoing endovascular aortic repair (EVAR).

Patients undergoing EVAR were retrospectively recruited. Based on Etoricoxib use, patients were divided into the non-treated and Etoricoxib-treated groups. Baseline characteristics including demographics, laboratory parameters, characteristics of aortic computer tomography and echocardiography, medications used, and procedural characteristics were collected from the electronic health record.

Compared to non-treated group (n=36), prevalence of obesity and fever at baseline was higher in Etoricoxib-treated group (n=24; P<0.05). Mean number of neutrophils, and mean serum CRP and D-dimer levels were higher in Etoricoxib-treated group (P<0.05). The overall incidence of hypoxia was lower in Etoricoxib-treated group (44.4% vs 33.4%, P<0.05). Increase in neutrophils count, serum CRP and D-dimer levels was associated with incident hypoxia, with an odds ratio (OR) of 1.36 (95% confidence interval [CI] 1.07-1.65), 1.44 (95% CI 1.12-1.78) and 1.25 (95% CI 1.01-1.47) respectively. In unadjusted model, Etoricoxib use was associated with a 44% lower odds of incident hypoxia. After adjustment for inflammatory markers, the association between Etoricoxib and incident hypoxia was non-significant, with OR of 0.95% and 95% CI of 0.78-1.06.

Compared to patients who did not receive Etoricoxib during hospitalization, those treated with Etoricoxib had lower incidence of hypoxia, which might be attributed to its anti-inflammatory effects.
Compared to patients who did not receive Etoricoxib during hospitalization, those treated with Etoricoxib had lower incidence of hypoxia, which might be attributed to its anti-inflammatory effects.Resibufogenin (RBG) is a chemical ingredient of Chan Su. In our research, we found RBG affected cardiac rhythm in a negative chronotropic way in vivo. The cardiac Mapping system ex vivo and the patch clamp in vitro were used to explore how RBG influenced the cardiac electrophysiological properties. The negative chronotropic action of RBG at 100 μM might be attribute to prolongation in the atrioventricular conduction time and reduction in the ventricular conduction velocity. read more Using whole-cell patch clamp in ventricular myocytes of adult rats, we found that RBG prolonged the action potential duration (APD) in APD20, APD50, and APD90 at 100 μM and inhibited calcium currents (ICa), total outward potassium currents (IK), and transient outward potassium current (Ito) in a concentration-dependent manner, but not on the inward rectifying potassium current (IK1). Notably, RBG had a potent proarrhythmic action ex vivo in the isolated perfused guinea pig hearts at 10 μM, but not in rats. To avoid the potential cardiotoxicity derived from the distributional differences of ion channels among species, the effect of RGB on IKr in hERG-HEK293 cells was detected.
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