Notes

miR-1229-3p like a Prognostic Forecaster Helps Cellular Practicality, Migration, and Attack of Hepatocellular Carcinoma.
maxillofacial prosthodontics was an important first step in providing context when interpreting the results of a survey of maxillofacial prosthodontists reported as Part II of this work.
Head and neck care has been transformed by the introduction of advanced digital technologies that will continue to be important change drivers for maxillofacial prosthodontics. Insight into these changes is important in answering the question of whether maxillofacial prosthodontics is appropriately prepared to contribute effectively to future multidisciplinary care of the head and neck.

The purpose of this survey was to gain insight into the perception of changes experienced by maxillofacial prosthodontists in relation to clinical practice. The findings of this survey may assist the future development of the subspecialty.

An exploratory cross-sectional survey was conducted by using a convenience sample of members of the American Academy of Maxillofacial Prosthetics. The survey considered 10 domains and 31 questions. Fully completed surveys (164) provided a 59% response. Descriptive statistics used percentage responses to reduce and characterize perceptions across respondents.

Eighty-four percent of tht to attract younger colleagues to the subspecialty, that barriers to advanced digital technology use included funding for equipment acquisition, institutional funding support, and remuneration for their use in care delivery, and that maxillofacial prosthodontic programs were not providing adequate education and training in advanced digital technologies.
Interim dental prostheses can be fabricated by using subtractive or additive manufacturing technologies. However, the fracture resistance of implant-supported interim crowns fabricated by using vat-polymerization additive manufacturing methods remains unclear.

The purpose of this invitro study was to evaluate the fracture resistance of anterior and posterior screw-retained implant-supported interim crowns fabricated by using subtractive and vat-polymerization direct light processing (DLP)additive manufacturing procedures.

An implant (Zinic Implant RP ∅4.0×10 mm) was placed in a 15×15-mm polymethylmethacrylate block. An implant abutment (ZiaCam, nonrotatory RP) was positioned on each implant. The virtual implant abutment standard tessellation language (STL) file provided by the manufacturer was imported into a software program (exocad v2.2 Valletta) to design 2 anatomic contour crowns, a maxillary right central incisor (anterior group) and a maxillary right premolar (posterior group). Each group was subdosterior group.
In spite of a digital workflow playing an important role in the intraoral prosthetic rehabilitation of patients with head and neck cancer, information about how it has been implemented and its clinical implications is sparse.

The purpose of this systematic review was to evaluate the use of a digital workflow in the intraoral prosthetic rehabilitation of patients with head and neck cancer by analyzing the frequency and type of the digital procedures used.

Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. The following terms were applied for the search conducted in the MEDLINE-PubMed, Cochrane, and SciELO databases (prosthesis OR dental OR rehabilitation) AND (digital OR CAD-CAM OR intraoral scanner) AND (Cancer OR head neck). Articles that specified data on intraoral prosthetic treatment and analyzed the use of a digital workflow in the different prosthetic phases such as digital scanning and computer-aided design and computer-aided manufacturing (CAD-Cin the intraoral prosthetic rehabilitation of patients treated for head and neck cancer. A digital workflow is used for specific stages but not for the entire process. More studies are needed to evaluate digital systems, ideally comparing parameters with the conventional method, and to determine whether this technique has more relevant clinical implications.
Use of ibuprofen for the patent ductus arteriosus (PDA) has become increasingly common. This study aimed to evaluate the clinical and economic impact of oral ibuprofen versus intravenous ibuprofen for PDA among preterm infants.

This retrospective, cohort-based pilot study examined the clinical and economic associations of oral versus intravenous ibuprofen for PDA. A decision-analytic model was constructed, from the hospital perspective, to follow the oral versus intravenous administrations of ibuprofen for PDA and their clinical and economic consequences. The course regimen of either formulation was an initial 10mg/kg followed by 5mg/kg at 24- and 48-h intervals. Clinical and resource utilization data were extracted from Cerner medical database, from 2014 through 2018, at the tertiary neonatal intensive care unit setting in Qatar. The primary outcome measures were the rate of successful closure based on the ductal diameter measure after the first course of treatment and the overall direct medical cost of results, followed by the occurrence of adverse drug events with both intravenous and oral ibuprofen. Although both ibuprofen formulations had similar safety profiles (P=0.16), the intravenous formulation was associated with a larger number of adverse drug effects.

This is the first cost-effectiveness evaluation of oral versus intravenous formulations of ibuprofen among infants with PDA. The oral ibuprofen might be associated with an enhanced ductal closure at a considerably lower cost. The study results support recent trends in neonatal intensive care unit practices in favor of the oral administration of ibuprofen.
This is the first cost-effectiveness evaluation of oral versus intravenous formulations of ibuprofen among infants with PDA. MYF-01-37 The oral ibuprofen might be associated with an enhanced ductal closure at a considerably lower cost. The study results support recent trends in neonatal intensive care unit practices in favor of the oral administration of ibuprofen.
Burnout is widespread among resident physicians, but higher resilience is associated with lower burnout. This study characterizes the relationship between resilience and burnout in medical (MR) and surgical (SR) resident physicians.

A cross-sectional survey was distributed to all ACGME-accredited residency programs with the Connor-Davidson Resilience Scale and Abbreviated Maslach Burnout Inventory.

Of the 682 respondents, both Medical and Surgical Residents with higher resilience had lower burnout. Higher resilience was seen in Surgical Residents who were men, had greater family support, more residency program support, and enjoyed greater autonomy. Burnout was greater in women, Caucasians, those in an academic setting, and with less autonomy and program support. Burnout was similar among the medical and surgical groups, but surgical trainees had higher resilience. Overall, family and institutional support was associated positively with high resilience and decreased burnout.

Increasing resilience and program support can decrease burnout, especially for high-risk subgroups.
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