Notes

Successful treatment along with crizotinib soon after alectinib-induced interstitial lungs ailment.
0401 mM-1s-1. Conclusion Gd3+/13X/FA/DOX nanocomposite shows a T1 relaxivity similar to the conventional gadolinium chelates, and a successful DOX loading. Copyright © 2020 Journal of Biomedical Physics and Engineering.Background Excessive range of adductory free moment of the ground reaction force may potentially increase the risk of lower extremity injuries by applying a higher torsional load transmitted to the proximal parts. Objective It was hypothesized that the free moment pattern might be different between hyper-pronated and normal feet subjects. Moreover, a correlation would exist between peak adduction free moment and peak ankle-foot complex abduction at the stance phase of walking. Material and Methods In this cross sectional study, thirty female participants were divided into two groups of asymptomatic hyper-pronated and normal feet. Kinetic and kinematic data were collected using a single force plate and a six-camera motion analysis system during three successful free speed walking trials. Ensemble average curves were extracted from the time normalized individual trials of the stance phase for both free moment and peak ankle-foot complex abduction parameters. Results Significant differences in peak adductory free moment, peak ankle-foot complex eversion and peak ankle-foot complex abduction were found between normal and hyper-pronated groups (4.90±0.97 Vs. 5.94±0.88, P less then 0.01), (3.30±0.95 Vs. 6.28±1.47, P less then 0.01) and (4.52±1.16 Vs. 8.23±2.52, P less then 0.01) respectively. A significant positive correlation was found between the peak adduction free moment and peak ankle-foot complex abduction in both groups, which was more strongly positive in hyper-pronated group (r = 0.745, p less then 0.01 for normal group and r = 0.900, p less then 0.01 for hyper-pronated group). Conclusion As a good measure of torque which is transmitted to the lower extremity, may free moment be a useful biomechanical indicator for both clinical and research purposes. Copyright © 2020 Journal of Biomedical Physics and Engineering.Background Nowadays, image de-noising plays a very important role in medical analysis applications and pre-processing step. Many filters were designed for image processing, assuming a specific noise distribution, so the images which are acquired by different medical imaging modalities must be out of the noise. Objectives This study has focused on the sequence filters which are selected by a hybrid genetic algorithm and particle swarm optimization. Material and Methods In this analytical study, we have applied the composite of different types of noise such as salt and pepper noise, speckle noise and Gaussian noise to images to make them noisy. The Median, Max and Min filters, Gaussian filter, Average filter, Unsharp filter, Wiener filter, Log filter and Sigma filter, are the nine filters that were used in this study for the denoising of medical images as digital imaging and communications in medicine (DICOM) format. Results The model has been implemented on medical noisy images and the performances have been determined by the statistical analyses such as peak signal to noise ratio (PSNR), Root Mean Square error (RMSE) and Structural similarity (SSIM) index. The PSNR values were obtained between 59 to 63 and 63 to 65 for MRI and CT images. Also, the RMSE values were obtained between 36 to 47 and 12 to 20 for MRI and CT images. Conclusion The proposed denoising algorithm showed the significantly increment of visual quality of the images and the statistical assessment. Copyright © 2020 Journal of Biomedical Physics and Engineering.Background Aging often results in thoracic kyphosis and adverse postural changes. This may interfere with physiologic activity of paraspinal muscles. Few styles of spinal orthosis have been already used to reduce thoracic kyphosis. This paper describes the development of a novel orthosis, which is designed based on the anatomy of the back muscles. This novel orthosis may potentiate muscle activity and balance control among older hyper kyphotic subjects. Chidamide mouse Objectives The object of this study was to design and preliminary testing of a new orthosis to potentiate muscle activity and balance control among older hyper kyphotic subjects. Material and Methods In this quasi-experimental study, a new postural control orthosis with a textile band structure was designed to provide an additional support for spine and muscles of the back. The functional impact of this orthosis was evaluated in six older hyper-kyphotic subjects. According to the results, the paraspinal muscles activity and balance control were significantly improved. Results The RMS sEMG of the lumbar and thoracic erector spinae muscles reduced significantly (p less then 0.05), and a significant improvement (p less then 0.05) was observed in the balance test when patients put on the novel orthosis (p less then 0.05). Conclusion The new orthosis can considerably improve the paraspinal muscles activity at both the upper and lower lumbar levels. It can also recover balance control among elderly subjects. Copyright © 2020 Journal of Biomedical Physics and Engineering.Background Recently, ultrasonic neuromodulation research has been an important and interesting issue. Ultrasonic neuromodulation is possible by the use of low-intensity transcranial focused ultrasound (tFUS) to stimulate or inhibit the neural structures. The primary capability of this method is the improvement in the treatment progress of certain neurological and psychiatric disorders noninvasively. tFUS is able to modulate ionic currents and neural depolarization, causing the alteration in electrical properties of neurons. Objective The study aims to investigate the effect of tFUS waves on the electrical behavior of neurons using the simulation method. Material and Methods In the first part of this simulation study, the propagation of tFUS waves throughout the head was simulated to calculate the value of acoustic pressure at the cortex. In the second part, cortical neurons were simulated by a simple model of spiking neurons proposed by Izhikevich for three common dynamics. Then, the capacitance model was proposed to determine the alteration in the electrical behavior of the neurons during tFUS stimulation.
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