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Multisystemic Cellular Tropism of SARS-CoV-2 inside Autopsies regarding COVID-19 People.
RESULTS Out-degree centrality and social activity scores were positively correlated with Mini-Mental State Examination (MMSE) scores only in women. In both genders, age and IADL scores were negatively associated with MMSE scores, while educational level was positively correlated. CONCLUSIONS Cognitive function of women was influenced by social activity and the number of members they considered friends. This finding suggests the influence of social networks on cognitive function differ by gender. Geriatr Gerontol Int 2020; •• ••-••. © 2020 Japan Geriatrics Society.Fluorescent proteins are investigated extensively as markers for the imaging of cells and tissues that are treated by gene transfection. However, limited transfection efficiency and lack of targeting restrict the clinical application of this method rooted in the challenging development of robust fluorescent proteins for in vivo bioimaging. To address this, a new type of near-infrared (NIR) fluorescent protein assemblies manufactured by genetic engineering is presented. Due to the formation of well-defined nanoparticles and spectral operation within the phototherapeutic window, the NIR protein aggregates allow stable and specific tumor imaging via simple exogenous injection. Importantly, in vivo tumor metastases are tracked and this overcomes the limitations of in vivo imaging that can only be implemented relying on the gene transfection of fluorescent proteins. Concomitantly, the efficient loading of hydrophobic drugs into the protein nanoparticles is demonstrated facilitating the therapy of tumors in a mouse model. It is believed that these theranostic NIR fluorescent protein assemblies, hence, show great potential for the in vivo detection and therapy of cancer. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.The metal-organic frameworks (MOFs) with long persistent luminescence (LPL) have caused widespread attention due to potential applications in displaying, anti-counterfeiting, and so on. However, MOF materials are often with large pore size, which restricts the formation of efficient inter- and intramolecular interactions to realize LPL. Herein, we report a new approach to achieve LPL in MOFs by multi-fold interpenetration of discrete frameworks. By the comparison between 3-fold and 2-fold interpenetrating MOFs, we found that the former with higher multiplicity and denser frameworks can be endowed with enhanced inter- and intramolecular interactions, and thus prolonged long persistent luminescence is obtained. Meanwhile, metal cluster and heavy halogen effect could also arouse variations in LPL durations and colours. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.INTRODUCTION AND AIMS We aimed to evaluate and compare the effect of different intravenous doses of naloxone on reinforcing effect of intravenous buprenorphine (2 mg) in patients stabilised on sublingual buprenorphine. DESIGN AND METHODS This is a double-blind, within-subject, randomised, crossover study. Opioid-dependent patients, with history of intravenous drug use, stabilised on buprenorphine maintenance treatment were included after informed consent (n = 14). We administered and assessed the reinforcing effects of six test conditions buprenorphine and naloxone co-formulation (BNX) in 41, 21 and 11 dose ratio (i.e. buprenorphine 2 mg + naloxone 0.5, 1 and 2 mg, respectively), buprenorphine alone (2 mg), pheniramine maleate (45.5 mg) and saline at 24 hourly intervals. RESULTS No significant opioid withdrawals were precipitated during any test conditions. Compared to buprenorphine alone, 41 BNX had comparable euphoria, drug recognition, subjective opiate sensations and drug liking (P > 0.05); 21 BNX condition had significantly different subjective euphoria (P = 0.001), opioid recognition (P = 0.002), subjective opioid sensations at 60 min (P = 0.027) and drug liking (P less then  0.001), while 11 BNX had significantly different objective euphoria (P = 0.002), opioid recognition (P = 0.030), subjective opioid sensations (P less then  0.001) and drug liking (P less then  0.001). No significant difference was noted on sedation scores between buprenorphine alone and all three combinations of BNX. DISCUSSION AND CONCLUSIONS The 41 BNX condition did not impact the reinforcing agonist effects of buprenorphine. None of the intravenous BNX combination ratios precipitated opioid withdrawals. Findings emphasise the need for exploring more abuse deterrent mechanisms. © 2020 Australasian Professional Society on Alcohol and other Drugs.This study reports a new amphiphilic bioconjugate (CAFF-LA) derived from lipoylation of a hydroxyethyl derivative of caffeine. The CAFF-LA self-assembles in water into nanospheres having an average size of 155 nm as evidenced from dynamic light scattering and electron microscopic studies. The nanospheres are stable in serum and could be disintegrated upon exposure to reducing environment of dithiothreitol (DTT; 10 mM) and glutathione (GSH; 10 mM). These nanospheres easily encapsulate the chemotherapy medication, doxorubicin (DOX) and demonstrate an efficacious cellular transport against doxorubicin resistant cervical cancer (HeLa) cells wherein marked induction in apoptosis and significantly lower IC50 have been observed when compared to that of free drug. The in vitro assessment of cell viability and hemocompatibility present these nanospheres as potentially safe and efficient intracellular reduction stimulus responsive drug delivery vehicles. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.Indolo[3,2-b]carbazole is a molecule of ambiguity and controversy, and, on the other hand, presents a π-skeleton with remarkable electronic structure and interesting potential applications. Herein, we report new derivatives of indolo[3,2-b]carbazole, which have enabled a comprehensive study on the electronic structure of indolo[3,2-b]carbazole and development of a new n-type organic semiconductor. Sodiumbutyrate It is found from experimental and computational studies that indolo[3,2-b]carbazole has a largely localized p-benzoquinonediimine moiety and significant antiaromaticity. When substituted with (4-silylethynyl)phenyl groups, indolo[3,2-b]carbazole exhibits one-dimensional π-π stacking and functions as an n-type organic semiconductor in solution-processed field effect transistors. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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