Notes

Identifying Young children in Readmission Threat: At-Admission as opposed to Classic At-Discharge Readmission Conjecture Model.
Despite the multifaceted effects of the medicines provided for COVID-19treatment, the number of the infected and mortality of patients increases which demonstrates the insufficient effectiveness of drugs used to fight coronavirus infections in medical practice, and clearly shows the need to develop new treatment tactics.In this review article are summarized and analyzed the literature data concerning specific features of COVID 19. Particular attention is given to genetic characteristic of this virus ,to mechanism of its invasion into the human organism, replication and interection with ACE-2 receptors ,as well as to the basic targets for the action of existing drugs with antiviral activity against COVID-19. Currently, the following medications are used to treat COVID-19 remdesivir, chloroquine, hydroxychloroquine (HCQ), ribavirin, lopinavir/ritonavir. According to a recent theory of coronavirus treatment, the starting point for the mechanism of action of a potential etiotropic drug is the inhibition of the coronavirus main protease (Mpro/3CLpro) and the papain-like protease (PLpro). Among the drugs listed above, lopinavir acts through this mechanism but is characterized by severe side effects.It is emphasized that remdesivir as adenosine analog provides inhibitory action on RNA dependent RNA-Polymerase,but there are controversial views about reduction in mortality during using of this drug against COVID-19. The present paper discusses the mechanism of action of a potential etiotropic drug against coronavirus, which implies the replacement of the nucleotides involved in the process of translation of the virus with their analogs with the aim to "inhibit" the ribosome and block the production of viral proteins.The article presents a retrospective analysis of the concept of occupational and emotional burnout syndrome in medical professionals in the field of mental health. The analysis of domestic and foreign scientific sources, biblio-semantic, analytical, and statistical research methods had used in work. The leading causes of burnout and their factors had identified. The study involved 224 respondents - the medical staff of the regional psychiatric hospital in Vinnytsia. Among the subjects were women - 84.8%, and men - 15.2%. Of the total number of subjects, doctors accounted for 38.8% (87 people), nurses - 61.2% (137 people). The average age of respondents among doctors was 44.6±12.2 years, among SMP 37.2±11.4 years. Work experience in professional activities was among doctors - 19.7±12.3 years and SMP - 15.5±11.1 years. For the experimental study had used, the psychodiagnostic method of emotional exhaustion Boyko V.V. and the adapted method of Vodopyanova N.E., The significance of the difference, was assessed using Student's t-test (t). Recommendations for mental health prevention measures for mental health professionals have developed. The prospect of further research on the problem of burnout is to study an effective system of prevention for the medical staff of health care institutions in Ukraine.For the purpose of research and comparative analysis of the features of cerebral blood flow, determined by the ultrasonic duplex scanning (USDS) method, in persons with clinical signs of chronic cerebral venous dysfunction syndrome and different levels of arterial pressure (AP), ultrasound of the head and neck was performed in 104 patients. 78 people - the main group (MG), where patients were selected for clinical signs of the presence of chronic cerebral venous dysfunction syndrome (CCVDS) and different blood pressure levels, were divided into 3 clinical groups 33 people - people with high blood pressure (157.2±12,2/98.3±4.2) - hypertensive patients; 24 people with labile blood pressure with predominantly normal average blood pressure (125.23±12.2/82.22±4.14) - conditional normotonics; 21 people with low blood pressure (100.32±7.23/65.45±6.4) were hypotonic. Also, 26 patients of the comparison group were recruited - people without clinical signs of CCVDS and different levels of blood pressure, distributed ac patients, a statistically significant acceleration of the linear blood flow velocity in vertebral artery at the level of the second cervical vertebra (VA2) was observed (p less then 0.05). In the subgroups of hypertensive patients with CCVDS, the mean linear blood flow velocity with a significant difference was twice less than the comparison group a significant decrease in velocity parameters was only in the middle cerebral arteriasis (MCA) basins on both sides (p less then 0.01, p less then 0.05 on the right and left, respectively) and on the left in the pools posterior cerebral artery (PCA), VA2, a significant increase in blood flow (p less then 0.01, p less then 0.05) - in the veins of Rosenthal (VR). This discrepancy can be explained by the fact that hypertensive patients from the comparison group, that is, without clinical symptoms of CCVDS, already have subclinical manifestations of CCVDS, as evidenced by changes in the USDS indicators.Cypress pollen allergy is a widely distributed, highly prevalent and severe winter pollinosis that may be caused by several Cupresaceae species around the Mediterranean basin, in North America and Asia. SRT2104 research buy Exposure to cypress pollen has increased steadily over the last few decades and the prevalence of allergy to cypress pollen has also dramatically increased from 0.6% to 9.8% in the general population and from 9% to 35% in allergic patients, probably because of the allergen load has become more intense. The objective of the study was to evaluate cypress pollen allergy in Georgia and describe clinical characteristics and the molecular profile of sensitization. Patients attended to allergy clinic with suspected cypress pollen allergy (n=492) were included in the study. Diagnostic workup was performed according to local guidelines, specific IgE antibody against cypress allergen was performed using ImmunoCAP and ISAC assay platform. The airborne pollen monitoring was performed with a Burkard Seven Day Volumetric Spsymptoms predominantly associated with allergic rhinitis and atopic conjunctivitis, in most cases which are expressing by acute sneezing and ocular itching during the pollen season and all patients are poly-sensitized. This was the first study to give a detailed description of the clinical characteristics of cypress pollen allergic patients in Georgia.
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