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spatial extent of activation for each stimulation. This might enable surgeons in the future to optimize the mapping process. Additionally, differences between tumor and nontumor stimulation sites were observed with respect to the spatial extent of the changes in cortical optical properties. These findings provide further evidence that the method allows the assessment of the functional state of neurovascular coupling and is therefore suited for the delineation of pathologically altered tissue.Poor radiotherapy outcome is in many cases related to hypoxia, due to the increased radioresistance of hypoxic tumour cells. Positron emission tomography may be used to non-invasively assess the oxygenation status of the tumour using hypoxia-specific radiotracers. Quantification and interpretation of these images remains challenging, since radiotracer binding and oxygen tension are not uniquely related. Computer simulation is a useful tool to improve the understanding of tracer dynamics and its relation to clinical uptake parameters currently used to quantify hypoxia. In this study, a model for simulating oxygen and radiotracer distribution in tumours was implemented to analyse the impact of physiological transport parameters and of the arterial input function (AIF) on oxygenation histograms, time-activity curves, tracer binding and clinical uptake-values (tissue-to-blood ratio, TBR, and a composed hypoxia-perfusion metric, FHP). Results were obtained for parallel and orthogonal vessel architectures and for vascular fractions (VFs) of 1% and 3%. The most sensitive parameters were the AIF and the maximum binding rate (Kmax). TBR allowed discriminating VF for different AIF, and FHP for different Kmax, but neither TBR nor FHP were unbiased in all cases. Biases may especially occur in the comparison of TBR- or FHP-values between different tumours, where the relation between measured and actual AIF may vary. Thus, these parameters represent only surrogates rather than absolute measurements of hypoxia in tumours. This paper reports a very high capacity and recyclable Mg-Co-Al-layered double hydroxide@ g-C3N4 nanocomposite as the new adsorbent for remediation of radioisotope-containing medical-based solutions. In this work, a convenient solvothermal method was employed to synthesize a new nano-adsorbent, whose features were determined by energy dispersive X-ray (EDS/EDX), XRD, FESEM, TEM, TGA, BET, and FT-IR spectroscopy. The as-prepared nano-adsorbent was applied to capture the radioisotope iodine-131 mainly from the medical-based wastewater under different conditions of main influential parameters, (i.e. adsorbent dose, initial I2 concentration, sonication time, and temperature). The process was evaluated by three models of RSM, CCD-ANFIS, and CCD-GRNN. Furthermore, comprehensive kinetic, isotherm, thermodynamic, reusability cycles and optimization (by GA and DF) studies were conducted to evaluate the behavior and adsorption mechanism of I2 on the surface of Mg-Co-Al-LDH@ g-C3N4 nanocomposite. High removal efficiency (95.25%) of 131I in only 30 min (i.e. during 1/384 its half-life), along with an excellent capacity that has ever been reported (2200.70 mg/g) and recyclability (seven times without breakthrough in the efficiency), turns the nanocomposite to a very promising option in remediation of 131I-containing solutions. Besides, from the models studied, ANFIS described the process with the highest accuracy and reliability with R2 > 0.999. Though having been applied for decades in the leachate treatment, membrane bioreactors (MBRs) have not attracted as much attention as their application in the municipal wastewater treatment. A timely survey for full-scale applications of MBRs treating leachate would be necessary to present a thorough knowledge and implication in this field. find more In this study, 175 full-scale MBRs treating leachate (with individual treatment capacity of ≥100 m3/d) in China were comprehensively analyzed. The accumulative treatment capacity exceeded 65,000 m3/d in 2018, and such projects were primarily distributed in areas with developed economy and large production of municipal solid waste. Sanitary landfill leachate owned 70 % of the leachate-treating MBRs' capacity, while the proportion for incineration plants increased gradually. Synchronously, leachate from incineration plants was more degradable than that from sanitary landfills. MBRs were advantageous to pollutant removal, fouling control, and successive energy mitigation of the whole treatment processes. The investment and footprint of processes adopting MBRs were medially ∼90,000 CNY/(m3/d) and ∼15 m2/(m3/d) respectively, and the energy consumption was 20-30 kW h/m3. The technical and economical applicability and environmental policy forces would strengthen a predictable increment of market share of MBRs in leachate treatment field in the future. In this paper, we have successfully prepared porous magnetic biochar with excellent surface area and recovery rate using corn stalks (CS) and waste iron (WI) as precursors. Notably, in order to prevent the incorporated iron oxides from blocking the carbon pores, then resulting in a decrease in specific surface area and reducing the removal efficiency of the material, the optimum range of iron ions can be determined to be 0.04-0.06 mol/L according to the effect of the amount of iron on the magnetic biochar recovery rate and Pb2+ removal capacity. Furthermore, as-synthesized artificial humic acid (A-HA) obtained from waste biomass by hydrothermal humification (HTH) technology has abundant functional groups, which can complex with heavy metals and metal oxides. Therefore, A-HA is introduced as an activator to produce novel porous magnetic biochar materials (AHA/Fe3O4-γFe2O3@PBC) with abundant functional groups (i.e., phenolic-OH, -COOH, etc.), providing high dispersibility and stability, further leading to excellent removal performance (Langmuir removal capacity up to 99.82 mg/g) and recyclable performance (removal capacity after 5 removal cycles is 79.04 mg/g). Multiple removal mechanisms have been revealed, including reduction, complexation, and precipitation.
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