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Patients with microtia and aural atresia have multiple options for treatment of conductive hearing loss (CHL) and auricle reconstruction; however, little is known about the factors influencing treatment selection. This study aims to review the socioeconomic and clinical data of microtia/atresia patients to evaluate congruency with national data and whether these factors affect treatment decisions.

Retrospective review of patients evaluated in the microtia and atresia multidisciplinary clinic (MDC) at a tertiary academic children's hospital between 2008 and 2018. Outcomes included demographic, socioeconomic and clinical factors associated with hearing surgery and framework surgery.

373 patients were seen in the Microtia MDC 193 (51.7%) were male, 187 (50.1%) identified as Hispanic and 23 (6.2%) identified as Asian. 267 (75.6%) patients received a nonsurgical bone conduction hearing device (BCHD); fitting at a younger age was associated with better nonsurgical BCHD compliance. Multivariate analysis was pe and framework surgery.Phytoplankton are characterized by a great phenotypic plasticity and amazing morphological variability, both playing a primary role in the acclimation to changing environments. However, there is a knowledge gap concerning the role of algal morphological plasticity in stress responses and acclimation to micropollutants. Cyclopamine research buy The present study aims at examining palmelloid colony formation of the green alga Chlamydomonas reinhardtii upon micropollutants exposure. Cells were exposed to four micropollutants (MPs, copper, cadmium, PFOS and paraquat) with different modes of action for a duration of 72 h. Effects of MPs on palmelloid formation, growth and physiological traits (chlorophyll fluorescence, membrane integrity and oxidative stress) were monitored by flow cytometry and fluorescence microscopy. Palmelloid formation was observed upon treatment with the four micropollutants. Number of palmelloid colonies and their size were dependent on MP concentration and exposure duration. Cells reverted to their unicellular lifestyle when colonies were harvested and inoculated in fresh medium indicating that palmelloid formation is a plastic response to micropollutants. No physiological effects of these compounds were observed in cells forming palmelloids. Palmelloid colonies accumulated lower Cd concentration than unicellular C. reinhardtii suggesting that colony formation protects the cells from MPs stress. The results show that colony formation in Chlamydomonas reinhardtii is a stress response strategy activated to face sub-lethal micropollutant concentrations.The co-contamination of naphthalene (NAP) and microcystin-LR (MC-LR) commonly occurs in eutrophic waters. However, the joint effects of NAP and MC-LR on plants in aquatic environments remain unknown. Landoltia punctata is characterized by high starch yields and high biomass in polluted waters and has been proven to be a bioenergy crop and phytoremediation plant. In this study, L. punctata was cultured in a nutrient medium with environmentally relevant NAP (0.1, 1, 3, 5, and 10 μg/L) and MC-LR (5, 10, 25, 50, and 100 μg/L) to determine individual and joint toxic effects. The effects of NAP and MC-LR on physiological responses of L. punctata, including growth, starch accumulation, and antioxidant responses, were studied. Bioaccumulation of MC-LR in L. punctata, with or without NAP, was also examined. The results showed that growth and chlorophyll-a contents of L. punctata were reduced at high concentrations of MC-LR (≥ 25 μg/L), NAP (≥ 10 μg/L) and their mixture (≥ 10 + 1 μg/L) after exposure for 7 d. Starch accumulation in L. punctata did not decrease when exposed to NAP and MC-LR, and higher starch content of 29.8 % ± 2.7 % DW could be due to the destruction of starch-degrading enzymes. The antioxidant responses of L. punctata were stronger after exposure to MC-LR + NAP than when exposed to a single pollutant, although not enough to avoid oxidative damage. NAP enhanced the bioaccumulation of MC-LR in L. punctata when NAP concentration was higher than 5 μg/L, suggesting that higher potentials of MC-LR phytoremediation with L. punctata may be observed in NAP and MC-LR co-concomitant waters. This study provides theoretical support for the application of duckweed in eutrophic waters containing organic chemical pollutants.
To examine the associations between screen time, the time spent on different screen devices, and sleep in a sample of Finnish preschool children.

The current study analyzed cross-sectional data from the DAGIS study carried out in Finland in 2015-2016 on 736 children aged 3-6 years. Parents reported in a 7-day diary the durations the child used screen devices daily, with separate details about watching TV or DVDs, using tablets or smartphones, and using computers. In addition, parents reported children's bedtimes and wake-up times, which were further used in calculating sleep duration. Parents answered questions regarding their child's sleep consistency. Statistical analyses included adjusted general linear modeling.

An hourly increase in total screen time was associated with 11 min later bedtime (p<0.001) and 10 min shorter sleep duration (p<0.001). More TV/DVD watching was associated with later bedtimes (p=0.016) and a shorter sleep duration (p=0.001). More smartphone/tablet use was associated with later bedtimes (p=0.005), later wake-up times (p=0.038), and weaker sleep consistency (p=0.024). More computer use was associated with later bedtimes (p=0.046). Results did not differ between genders.

Increased screen time was associated with later bedtimes and shorter sleep duration among preschool children. Adverse associations with sleep outcomes were found for each screen device. Attention should be paid to promoting balanced use of screens and regular sleep habits in young children.
Increased screen time was associated with later bedtimes and shorter sleep duration among preschool children. Adverse associations with sleep outcomes were found for each screen device. Attention should be paid to promoting balanced use of screens and regular sleep habits in young children.
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