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Postmortem examination revealed neoplastic erythroblasts infiltrating the bone marrow and other organs. Neoplastic cells were immunopositive for CD71 but immunonegative for CD3, CD20, granzyme B, von Willebrand factor, CD61, myeloperoxidase, and Iba-1. Although further studies are necessary for the application of CD71, our results supported the morphologic diagnosis of AML M6-Er.Savoring has covaried inversely with cannabis problems and moderated the association between cannabis use and negative consequences related to use. Research has not yet addressed the acceptability of savoring interventions for cannabis users. The present study aimed to replicate the finding of savoring as a protective factor against problems for cannabis users. The second aim of the study was to examine preferences for a savoring intervention among problem-endorsing cannabis users. We sampled 447 (63.3% female) problem users who self-reported cannabis use, cannabis problems, savoring beliefs, and preferences for cannabis use interventions. On average, our sample reported using cannabis 4.7 days per week and 16.03 times per month, with men endorsing significantly more cannabis-related problems than women. Savoring did increase as problems decreased, but the moderator effect did not replicate. Problem cannabis users preferred a savoring intervention to a typical harm reduction intervention across all sampled demographics, with one notable exception women were 1.73 times more likely to prefer a savoring intervention. Our findings confirmed that cannabis problems decrease as savoring increases and identified a preference for a savoring intervention among problem users.A novel macroporous strong acidic cation exchange resin (D001) modified by nano-sized goethite (nFeOOH@D001) was fabricated by using a facile ethanol dispersion and impregnation method, and its efficiency for Cr(VI) removal was tested thereafter. Due to the dispersing effect of ethanol, FeOOH particles of 20-150 nm were coated on the D001 surfaces. The nFeOOH@D001 obtained a Cr(VI) removal efficiency and capacity of 80.2% and 7.4 mg/g respectively, 5 times and 8 times higher than that of the pristine D001. The Cr(VI) removal by nFeOOH@D001 followed the pseudo second-order kinetics and the Langmuir adsorption model. Column experiments also demonstrated that the nFeOOH@D001 exhibited a much better ability to remove Cr(VI) as compared to the D001. Additionally, the nFeOOH@D001 showed a potential for reusability and renewability. The adsorbed nFeOOH@D001 could be easily desorbed by 0.1 M acetic acid and a reuse efficiency of 92.7% could be maintained after 4 desorption-adsorption cycles. The used nFeOOH@D001 could be eluted by 0.1 M HCl to remove nFeOOH, and the renewed D001 could be recoated by nFeOOH and achieved a regeneration rate of 97.8% for Cr(VI) removal. The above results indicated that nano-sized goethite modification is a promising method to endow D001 with the ability to remove Cr(VI) from water.
The influence of tumor location on survival was investigated in patients with lung cancer who received radical chemoradiotherapy.
We examined the relationships between radiation site and survival outcome in patients with lung cancer. A total of 14,640 patients with lung cancer who received radical chemoradiotherapy for stage I-III disease were reviewed from Surveillance, Epidemiology, and End Results Program (SEER) datasets. We further retrospectively collected cases from a cohort of 148 eligible patients diagnosed between December 2013 and December 2019.
Female sex, adenocarcinoma, and stage III disease were significantly correlated with right lung lobe tumor. Advanced age at diagnosis was associated with lower lung tumor origin. For the patients who received radical chemoradiotherapy, 1- and 3-year survival rates were 56.5% and 22.9%. Lower lobe origin was closely related to a shorter overall survival compared to non-right lower lobe tumors (
< 0.001). We also validated the difference in our cohort (
= 0.004).
Our results suggest that lower lobe tumor increases mortality risk in patients with lung cancer treated with radical chemoradiotherapy.
Our results suggest that lower lobe tumor increases mortality risk in patients with lung cancer treated with radical chemoradiotherapy.Sodium hypochlorite is considered the most widely used irrigant in endodontics as it exhibits effective antimicrobial activity and has potent tissue-dissolving ability. Whilst it is considered safe when used within the confines of the root canal system, it can cause serious complications when inadvertent periradicular extrusion occurs. This article outlines the complications of sodium hypochlorite extrusion and reviews the appropriate management based on the contemporary evidence. Preventive measures are suggested and the relevant medico-legal considerations are outlined.Dentists are likely to encounter lesions that have both periodontal and endodontic aetiological components; the so called 'perio-endo lesions'. A thorough examination with appropriate investigations remains pivotal to diagnosing a perio-endo lesion. Correct diagnosis of such lesions is therefore important as it enables the most suitable clinical management to be treatment planned. It is still recommended that for the treatment of perio-endo lesions, initial endodontic therapy is completed.Difficulties encountered during endodontic treatment can be a cause of frustration for both clinician and patient. Complications such as iatrogenic perforation, ledge formation, canal blockage, instrument separation and untreated anatomy may impact the outcome of endodontic treatment. Clinicians should understand how each of these complications can occur, be prevented and predictably rectified. It is also important for clinicians to understand the impact of a specific complication on treatment prognosis and to appreciate how this may differ in each case. There may be scenarios where a complication does not significantly affect the prognosis, whereas in other situations, the same complication will be detrimental to the outcome of treatment. selleck compound An appreciation of the clinical factors which determine prognosis is important, so that the correct intervention is chosen, and the patient is correctly informed of the likely sequelae.
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