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Get older Trajectories regarding Perceptual Pace along with Isolation: Isolating Between-Person and also Within-Person Interactions.
This outcome suggests the importance of using an accurate actuator model in simulations of human movement augmented by assistive devices. NOVELTY Demonstrating the effects of including mass and internal dynamics of the actuator in simulations of assisted human movement A new OpenSim electric motor actuator class to capture the electromechanical dynamics for use in simulation of human movement assisted by powered robotic devices. © 2020 John Wiley & Sons, Ltd.We thank Drs. Shingina and Montenovo for their thoughtful comments on our manuscript (1, 2). We are delighted that they share our concerns about the importance of informed consent for live liver donation. We agree that live donors need to be made aware of the small possibility of post-donation liver failure, need for transplantation, or death, and live liver donor recipients need to understand the higher chance of biliary and vascular complications. This article is protected by copyright. All rights reserved.The zebrafish (Danio rerio) is a small teleost fish that is becoming increasingly popular in laboratories worldwide and several attributes have also placed the zebrafish under the spotlight of (eco)toxicological studies. Since the 1990s, international organizations such as ISO and OECD have published guidelines for the use of zebrafish in ecotoxicological assessment of environmental toxicants such as the Fish Embryo Acute Toxicity (FET) test, OECD n° 236 guideline. This protocol uses 3,4-dichloroaniline (DCA), an aniline pesticide whose toxicity to fish species at early life stages is well known, as a positive control. Despite its use, little is known about its molecular mechanisms, especially in the context of the FET test. Therefore, this study aimed to investigate such changes in zebrafish larvae exposed to DCA (4 mg/L) for 96 hours using gel-free proteomics. Twenty-four proteins detected in both groups were identified as significantly affected by DCA exposure, and, when considering group-specific entities, 48 proteins were exclusive to DCA (group-specific proteins) while 248 were only detected in the control group. Proteins modulated by DCA treatment were found to be involved in metabolic processes, especially lipids and hormone metabolism (eg, Apoa1 and Apoa1b and vitelogenins), as well as proteins important for developmental processes and organogenesis (eg, Myhc4, Acta2, Sncb, and Marcksb). The results presented here may therefore provide a better understanding of the relationships between molecular changes and phenotype in zebrafish larvae treated with DCA, the reference compound of the FET test. © 2020 Wiley Periodicals, Inc.Pencil beam scanning proton therapy makes possible intensity modulation, resulting in improved target dose conformity and organ-at-risk (OAR) dose sparing. selleck chemicals This benefit, however, results in increased sensitivity to certain clinical and beam delivery parameters, such as respiratory motion. These effects can cause plan degeneration, which could lead to decreased tumor dose or increased OAR dose. This study evaluated the measurements of proton pencil beam scanning delivery made with a 2D ion chamber array in solid water on a 1D motion platform, where respiratory motion was simulated using sine and cosine4 waves representing sinusoidal symmetric and realistic asymmetric breathing motions, respectively. Motion amplitudes were 0.5 cm and 1 cm corresponding to 1 cm and 2 cm of maximum respiratory excursions, respectively, with 5 sec fixed breathing cycle. The treatment plans were created to mimic spherical targets of 3 cm or 10 cm diameter located at 5 cm or 1 cm depth in solid water phantom. A reference RBE dose of 200 cGy per fraction was delivered in 1, 5, 10, and 15 fractions for each dataset. We evaluated dose conformity and uniformity at the center plane of targets by using the Conformation Number and the Homogeneity Index, respectively. Results indicated that dose conformity as well as homogeneity was more affected by motion for smaller targets. Dose conformity was better achieved for symmetric breathing patterns than asymmetric breathing patterns regardless of the number of fractions. The presence of a range shifter with shallow targets reduced the motion effect by improving dose homogeneity. While motion effects are known to be averaged out over the course of multifractional treatments, this might not be true for proton pencil beam scanning under asymmetrical breathing pattern. © 2020 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine.PURPOSE To investigate the set-up error and consequent dosimetric change in HexaPOD evo RT 6D couch under image-guided intensity-modulated radiotherapy (IG-IMRT) for primary malignant tumor of the cervical spine. METHODS Ten cases with primary malignant tumor of the cervical spine were treated with intensity-modulated radiotherapy (IMRT) in our hospital from August 2013 to November 2014. The X-ray volumetric images (XVI) were scanned and obtained by cone-beam CT (CBCT). The six directions (6D) of set-up errors of translation and rotation were obtained by planned CT image registration. HexaPOD evo RT 6D couch made online correction of the set-up error, and then the CBCT was conducted to obtain the residual error. RESULTS We performed set-up error and dosimetric analysis. First, for the set-up error analysis, the average error in three translation directions of 6D set-up error of the primary tumor of the cervical spine was less then 2 mm, whereas the single maximum error (absolute value) is 7.0 mm. Among averaiation of Physicists in Medicine.INTRODUCTION There is limited evidence about the prognostic value of FDG-PET/CT metrics in small cell lung cancer (SCLC) patients staged with TNM staging system. OBJECTIVES The aim of this study is to examine the prognostic value of pretreatment FDG-SUVmax in patients with SCLC staged with 8th TNM staging system. METHODS A total of 344 (292 male) SCLC patients with pretreatment FDG- PET/CT were included. One hundred fifty-three of cases were stages I-III, 191 were stage IV. SUVmax values were obtained for primary tumour, lymph nodes and metastases. Univariate and multivariate analysis were performed to determine the effect of pretreatment SUVmax, with cut-off value of median, on progression-free and overall survival (PFS and OS). RESULTS Median OS and PFS for patients with stages I-III were 16.50 and 11.00 months, respectively. Median OS and PFS for patients with stage IV were 10.00 and 7.00 months, respectively. SUVmax of the primary tumour (PT), lymph nodes or metastasis were not associated with OS and PFS on univariate analysis.
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