Notes

Lazarus Reply to Tepotinib for Leptomeningeal Metastases in the Affected individual With MET Exon 18 Missing Mutation-Positive Lung Adenocarcinoma: Scenario Statement.
In on-farm hatching systems, eggs are transported at d 18 of incubation to the broiler farm, where chickens have immediate access to feed and water after hatching. In hatchery-fed systems, newly hatched chickens have immediate access to feed and water in the hatchery and are transported to the farm thereafter. Conventionally hatched chickens can remain without access to feed and water up to 72 h after hatching until placement on the farm. The current study compared day-old chicken quality, performance, and slaughter yield of broiler chickens that were on-farm hatched (OH), hatchery-fed (HF), or conventionally hatchery-hatched (HH). The experiment was performed in 6 rooms in 1 house. Each room contained 2 duplicate pens with approximately 1,155 chickens per pen; 2 rooms with each 2 duplicate pens were assigned to 1 treatment. The experiment was repeated during 3 consecutive production cycles. Chickens originated from young parent stock flocks. Results showed that HF and OH chickens were heavier and longer than HH chickens at day (D) 1. Relative weight of stomach and intestines were highest for OH chickens. The OH chickens had worse day-old chicken quality in terms of navel condition and red hocks than HH and HF chickens. Treatments did not differ in first wk and total mortality. From D0 until slaughter age, body weight was highest for OH, followed by HF and HH. Furthermore, carcass weight at slaughter age (D40) was highest for OH chickens, followed by HF and HH chickens. Breast fillets showed a higher incidence of white striping and wooden breast in HF and OH chickens compared with HH chickens. In conclusion, the current study showed that both OH and HF chickens of young parent flocks had better growth performance, which could explain the higher prevalence of breast myopathies, compared with HH. The worse day-old chicken quality for OH compared with HH and HF does not seem to affect first wk mortality and later life performance.This study was conducted to explore whether dietary pectic oligosaccharide (POS) supplementation could improve gut health of broiler breeders with different egg-laying rates. A 2 × 2 factorial design was used in this study. Two hundred fifty-six Arbor Acres broiler breeders (48 wk of age), including 128 average egg-laying rate and 128 low egg-laying rate (LELR) birds, were randomly fed with the diets supplemented with or without 200 mg kg-1 of POS (n = 8). The trial lasted for 8 wk. Compared with average egg-laying rate broiler breeders, LELR broiler breeders had lower laying rate and qualified egg rate (P less then 0.05), higher egg weight and feed conversion ratio (P less then 0.05), higher malondialdehyde (MDA) levels in the jejunum (P less then 0.05), higher IL-6 (P less then 0.05) and tumor necrosis factor α (TNF-α) (P = 0.07) mRNA expressions in the jejunal mucosa, and lower microflora diversity in cecal digesta. Dietary POS supplementation increased egg weight of broiler breeders (P less then eders with different egg-laying rates.This study was conducted to evaluate the effects of the fiber source (wheat bran [WB] or sugar beet pulp [SBP]) and xylanase supplementation on production, egg quality, ileal digestibility, intestinal morphology, and gastrointestinal pH in aged laying hens. BzATP triethylammonium in vivo A total of 540 laying hens (Lohman LSL Lite; 70 wk of lay) were randomized into 10 treatments (6 replicate cages of 9 birds) consisting of a corn soy control supplemented with 0, 3, or 6% WB or SBP with or without xylanase (100 mg of xylanase preparation per kg) for a period of 9 wk in a 5 × 2 factorial arrangement. Hens fed with the diets containing either of the levels of SBP or 6% WB had lower hen-day production, and addition of the enzyme improved hen-day production (P less then 0.05), but it could not compensate for the lost production due to the higher levels of either of the fiber sources. Supplementation of 6% SBP to the control diet decreased egg mass (P less then 0.05). All fiber-supplemented diets significantly decreased ADFI, which was restility.
Over the past two decades, the average age of hip fractured patients has increased, patients are increasingly fragile and their management is more complex. Most of the literature suggest that care improvement lowered short-term mortality but there is no clear evidence whether mid- and long-term mortality rates are improving. The aim of this study was to evaluate the variations in comorbidities in hip fractured patients over 15 years, the changes in mortality and identify the predictive factors for mortality for identifying the patients at higher risk.

Hip fractured patients admitted in hospital in 2000-2001 (192 patients) and 2015-2016 (323 patients) were retrospectively reviewed. Demographic, clinical and management data from the two cohorts were compared. Thirty-day and 1-year mortality were calculated and compare between the two cohorts. A multivariate logistic regression model were performed to identify the most significant predictors of mortality.

After fifteen years, mean age of hip fracture patierbidities were hypertension, COPD, diabetes, arrhythmia, renal impairment and dementia. In the 2015-2016 cohort, the age-adjusted mortality at 30 days significantly declined compared to the 2000-2001 cohort (respectively 6.9% vs. 12.5%) but the age-adjusted mortality at 1-year was equivalent. Older age, reduced mobility, higher comorbidity, lateral fractures and male sex were significant risk factors for reduced survival time CONCLUSIONS After 15 years, there was a significant improvement in 30-days mortality in hip fractured patients despite their increase in comorbidities but this advantage was not observed in 1-year mortality. This suggests the need to implement targeted and longer-term care support for males, older patients and those with greater comorbidities which are at higher risk.
Hip fracture is a common and serious injury in the elderly. Hip arthroplasty is the most frequently performed procedure for patients with an intracapsular hip fracture. The majority of national guidelines recommend total hip arthroplasty (THA) for more active patients. Literature indicates significant stability advantages for dual mobility (DM) acetabular components in non-emergent scenarios. Evidence supporting the use of DM in hip fracture patients is limited.

We set out to ascertain if DM implants offer stability and/or functional advantages over standard THA in patients with hip fracture.

We utilised our local National Hip Fracture Database to identify all patients undergoing either a standard or DM THA for hip fracture (n=477) We matched cohorts based on age, AMTS, mobility status pre-operatively, gender, ASA and source of admission. Our primary outcome of interest was functional status using the oxford hip score (OHS). Secondary outcome measures included dislocation, fracture and deep infection requiring further surgery.
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