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Process design and control over a twin twist very hot dissolve extrusion with regard to ongoing pharmaceutical tamper-resistant capsule generation.
818%), Cr (0.274%), and Na (3.611%) in breast milk of women with PD. Children born to mothers with PD had a significantly increased level of Cr (0.92%), S (0.578%) and P (0.169%), Na (0.107%), Ca (56.041%), and Zn (7.149%). CONCLUSION Conclusions PD has a negative impact on the pregnancy and labor and may be one of the factors causing the mineral imbalance of breast-fed infant.OBJECTIVE The aim of investigation was to study the structural and functional conditions of cortical and trabecular layers of lumbar vertebrae L1-L5 in different age groups. PATIENTS AND METHODS Materials and methods In order to assess BMD of the lumbar vertebrae 102 people18 to 75 years old was examined. Study of bone mineral density cortical and trabecular layer of lumbar vertebrae (L1-L5) performed by computed tomography in Hounsfield Units (HU) in terms of standard deviation (SD). RESULTS Results The results of computed tomography showed a direct relationship of bone mineral density of lumbar vertebrae with age of examined persons. Osteoporosis and osteopenia was registered in 15% of men and 30% women in middle adulthood, in late adulthood - 35% and 50% respectively. During early old age osteopenia and osteoporosis are observed in 37,5% and 25% of men and 26% and 64% women. Osteoporosis in the middle old age has been reported in 50% of men and 75% of women. see more CONCLUSION Conclusions Results of the study showed a direct link between mineral density, age and gender. The middle adulthood age period was characterized by the highest mineral mass compared with the other age periods. Then there is a loss of bone mass throughout life, and with the onset of aging osteopenia and osteoporosis are recorded. It was investigated that in the early old age, loss of bone mass is mainly observed in female.OBJECTIVE The aim was to investigate SNPs of TLR-2,3,4, NOD2/CARD15, JAK-2, and IL-10 in patients with the early and late UC onset. PATIENTS AND METHODS Matherials and methods 126 patients with UC were investigated. To assess the predisposition of the early and late UC onset the incidence of the following SNPs Arg753Gln TLR2 gene, Phe412Leu TLR3 gene, Asp299Gly and Thr399Ile TLR4 gene, C-819T, G-1082A and C-592A gene IL-10, Val617Phe gene JAK2, Gly908Arg gene NOD2/CARD15 were analyzed. RESULTS Results 76 patients had early disease onset and 50 had a late one. SNPs of TLR3 were observed in 50.8% cases. TLR4 polymorphism was more common than TLR3, and was observed in 81 (64.3%) UC patients. Polymorphism of NOD2/CARD15 and IL-10 genes were revealed with almost the same frequency 49 (38.9%) and 50 (39.9%) patients, respectively. CONCLUSION Conclusions Polymorphisms of TLR-2,3 genes and TLR4 Asp299Gly, NOD2/CARD15 prevailed in patients with the late UC onset that allows to suppose that bacterial flora plays one of the key roles in modification of immune response and UC development. In patients with early UC onset polymorphisms of the JAK2 and IL-10 genes prevailed responsible for the cytokine cascade activation and cause the immune mechanism that might lead to a more aggressive course of the disease.OBJECTIVE The aim To study the possibilities of ultrasound in adhesive ileus obstruction diagnosis and indications for surgical treatment determination. PATIENTS AND METHODS Materials and methods The results of diagnosis and treatment of 60 patients with acute adhesive intestinal obstruction with comparative use of X-ray and ultrasound methods were analyzed. RESULTS Results The use of a standard X-ray examination of the abdominal organs upon admission to the hospital allowed the diagnosis of acute adhesions of small bowel obstruction in only 32 (53.3%) patients. Transabdominal ultrasonography allowed the establishment of adhesive ileus during hospitalization in 53 (88.3%) patients and also in 7 (11.7%) during a dynamic examination 2-3 hours after admission. Due to the lack of positive effect from the conducted conservative therapy relying on the data of ultrasound studies, 33 (55%) patients were operated on. During X-ray examination, only 10 (30.3%) of these patients demonstrated negative X-ray dynamics, and with an ultrasound study, deterioration of echo pictures was observed in all 33 (100%) patients. CONCLUSION Conclusions Compared with the X-ray method, transabdominal ultrasonography is established to be safe, affordable, simpler, non-invasive and highly informative method for the study of acute adhesions of the small intestinal obstruction. The method allows the assessment of the ongoing conservative therapy dynamics and determination for surgical treatment indications.OBJECTIVE The aim To study the biological properties of museum and clinical strains of E.coli isolated from patients with peritonitis. PATIENTS AND METHODS Materials and methods It was used 94 strains (clinical, museum and reference). The ability of E. coli to adhere was investigated by hemadhezive method to formal human erythrocytes of 0 (I) Rh-positive blood group. The study measured the ability of microorganisms to produce gelatinaze, caseinase, fibrinolysin, hemolysin. To control of the enzyme activity the positive and negative control with reference strains were used. Synchronisation of cultures activity before experiments was achieved by one-time effect of low temperature (+4 С) during 30 minutes. RESULTS Results To investigate the pathogenic factors of E. coli we carried out determining of proteolytic, gelatinous, caseinous, fibrinolytic, haemolytic and adhesion properties. CONCLUSION Conclusions In our investigation pathogen icspecies of Esherihies are virtually indistinguishable from representatives of normal microflora on its morphological, biochemical and cultural properties. During investigation of serological properties of selected of E. coli strains (n = 94) 65.8% of pathogenic serotypes were revealed. Moreover, all marked E. coli isolated from the abdominal cavity of children and adults, as well as museum strains related to enteropathogenic E. coli (O127 K63, O33 K-) and 1 - to enteroinvazive Escherichia coli (O144 K-).OBJECTIVE The aim To study and evaluate the condition of the dental health of children of school age and the characteristics of their food. PATIENTS AND METHODS Materials and methods Statistics on the dental health of children in Transcarpathian region for the years 2009-2018 were analyzed with the application of statistical, sociological and clinical methods and the data on dental health and way of nutrition of 163 children in Uzhgorod were determined and analyzed. RESULTS Results and conclusions Reduction of 28.9% of coverage of children with preventive dental examinations was determined with the need for mouth cavity sanation of 45.93%. Redevelopment was held for 91.7% of those who needed help. From 10% to 50% of the examined children in different age groups have caries. Up to 10% of children between 11 and 15 years old have teeth removed. It was determined that nutrition of children with caries diagnosed is not rational.
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