Notes

ACSL: Adaptable correlation-driven sparsity learning with regard to deep neurological circle compression.
56 in the Bland Altmann plot. CONCLUSIONS The BHQ is translated and validated in Danish and retains good validity properties. This questionnaire is ready for use in daily clinical practice among Danish-speaking patients. FUNDING none. TRIAL REGISTRATION not relevant. Articles published in the DMJ are “open access”. This means that the articles are distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits any non-commercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.INTRODUCTION This study presents outcomes and follow-up tools for children born very (28 + 0 - 31 + 6 weeks) and extremely (22 + 0 - 27 + 6 weeks) preterm in a Danish sub-cohort of the European project Effective Perinatal Intensive Care in Europe (EPICE) cohort. METHODS All live and stillbirths with a gestational age 22 + 0 - 31 + 6 weeks from eight hospitals in Eastern Denmark (Funen, Zealand, Lolland and Falster) in 2011-2012 were included in the cohort (n = 441). Questionnaires were sent to parents at two and five years (including subscales of the Ages and Stages Questionnaire (ASQ)). Full-scale IQ and motor function were assessed by professionals in extremely preterm children at five years of age using the Wechsler Preschool and Primary Scale of Intelligence and Movement Assessment Battery for Children. RESULTS The study included 141 extremely and 210 very preterm live-born children, and among these 87 and 199 survived to discharge, respectively. The full-scale IQ was not significantly lower in children with potential developmental difficulties according to the ASQ. Children with parental reporting of fine motor difficulties had a poorer overall motor function (mean difference 2.8 (95% confidence interval (CI) 1.2-4.5)) and fine motor function (mean difference 3.4 (95% CI 1.7-5.1)) than children with no reported fine motor difficulties. CONCLUSIONS Few severe difficulties, e.g., cerebral palsy, were found. At five years, parental reporting on fine motor skills was associated with fine and overall motor skills as assessed by professionals. FUNDING none. TRIAL REGISTRATION not relevant. Articles published in the DMJ are “open access”. This means that the articles are distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits any non-commercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.INTRODUCTION Stoma-site incisional hernia is a common complication. Besides decreasing affected patients' quality of life, it may lead to emergency surgery due to incarceration. If stoma sites lead to an incisional hernia analogous to other abdominal incisions, considerable underreporting may be present in the literature. METHODS This was a single-centre, retrospective cohort study comprising consecutive patients undergoing laparoscopic rectal resection for rectal carcinoma with temporary diverting stoma and subsequent stoma reversal. learn more CTs were reviewed to identify stoma-site incisional hernia, and potential confounders for development of a hernia were assessed. RESULTS A total of 91 patients underwent stoma reversal and subsequent CT. In all, 72 of the 91 included patients had a transverse colostomy, among whom 19 (26%) developed a hernia. Among the remaining 19 patients treated with an ileostomy, four (21%) developed stoma-site incisional hernia. The mean time from stoma reversal to follow-up CT was 47.6 months (range 28.5-66.7 months). No significant associations between stoma-site hernia and the included potential risk factors were observed. CONCLUSIONS 25% developed reversal-site incisional hernia. We were unable to find any predictors for development of stoma reversal-site hernia. If hernias occur as frequently as this study shows, investigation of potential ways to decrease their occurrence is warranted. FUNDING none. TRIAL REGISTRATION The study was approved by the Danish Data Protection Agency (R. no. 2012-58-0004). Articles published in the DMJ are “open access”. This means that the articles are distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits any non-commercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.INTRODUCTION Age-related macular degeneration (AMD) is a leading cause of vision loss in elderly people. Several single-nucleotide polymorphisms (SNP) have been shown to either increase or reduce the risk of developing AMD. In this study, we investigated the frequency of ten known risk alleles in a Danish cohort across subtypes of late AMD and explored any relationship to accelerated development of bilateral neovascular AMD. METHODS A total of 206 participants were included, 73 hereof had neovascular AMD, 57 geographic atrophy (GA), 28 polypoidal choroidal vasculopathy (PCV) and 48 were healthy aged controls. Genotyping was performed using the Kompetitive allele-specific polymerase chain reaction genotyping assay. Participants with neovascular AMD were followed in the clinic for four years and registered as having developed bilateral disease or having persistent unilateral disease. RESULTS We found that patients with neovascular AMD and GA, but not PCV, had a higher frequency of the risk allele for rs10490924tion in any medium, provided the original author(s) and source are credited.This is a case report of a 63-year-old woman, who had worked as a laboratory animal keeper for 23 years. She developed increasing symptoms of rhinitis, coughing and shortness of breath and was diagnosed and treated for COPD based on her smoking history and spirometry results. She went on sick leave due to dyspnoea, and after testing she was diagnosed with occupational allergic asthma from rodents. Her lung function was at this point significantly reduced. Occupational asthma is common, and occupational causes of respiratory symptoms should always be taken into consideration when assessing patients in the working population.Diagnosing tuberculosis (TB) in children and adolescents pose a diagnostic challenge due to sparse symptoms and clinical signs. Children are at a much higher risk than adults of progression to severe disease. In this review, the presentation and management of childhood TB is described. TB in children indicates ongoing transmission and is an indicator of failing disease control in the community. Tests suited to predict progression are warranted, and targeting latent infection is essential to achieve TB elimination. We recommend a low threshold for referral of children suspected of active or latent TB.
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