Notes

Determination of teicoplanin throughout human lcd by change micelle mediated dispersive liquid-liquid microextraction with high functionality water chromatography.
The role of Renin-Angiotensin-System (RAS) in the pathogenesis of preeclampsia and eclampsia is still unclear. Our aim was to investigate plasma angiotensin II concentration [Ang II] in women with normotensive pregnancies (NP, n = 22) and severe preeclampsia in use of magnesium sulfate (SPE, n = 29). Despite no difference between the groups (SPE 47.8 pg/ml vs NP 39.7 pg/ml, p = 0.195), lower maternal age (p = 0.007) and primigravida (p = 0.028) were associated with lower [Ang II]. Plasma [Ang II] increased over the 24 h of magnesium sulfate administration (r = 0.48, p = 0.009). selleck compound Our findings suggest that RAS may be involved with the mechanism of magnesium protection against eclamptic seizure.
Minimally-invasive intraparenchymal hemorrhage (IPH) evacuation may provide a functional and mortality benefit, especially if there is minimal residual hematoma. Several methods have been used to confirm extent of IPH evacuation, including intraoperative computed tomography (CT). We sought to evaluate the feasibility of intraoperative CT in endoscopic-assisted IPH evacuation, with a focus on the operative workflow and imaging quality.

We retrospectively reviewed all endoscopic-assisted IPH evacuation procedures utilizing intraoperative CT performed at our institution over a 9-month period. We describe the operative room setup and workflow for using intraoperative CT and compare the intra- and postoperative imaging findings.

Eight consecutive procedures were included in this study. Intraoperative CT provided useful information that informed intraoperative decision-making in each case. There were no clinically significant differences in residual hematoma volume or midline shift between intra- and postoperative CT scans. Streak artifact was present in all cases due to the head holder, but did not significantly inhibit image evaluation.

Intraoperative CT is an effective method of evaluating the extent of IPH evacuation in endoscopic-assisted procedures.
Intraoperative CT is an effective method of evaluating the extent of IPH evacuation in endoscopic-assisted procedures.
Endovascular thrombectomy has revolutionized treatment of ischemic stroke. Given the clinical and socioeconomic support for thrombectomy, new devices, procedures, and pharmaceuticals have emerged in recent years, and have been subject to a growing number of clinical trials worldwide.

To define the current state of thrombectomy clinical trials, highlight recent trends, and help guide future research in this area.

Current and previous clinical trials involving thrombectomy for ischemic stroke were queried from the Clinicaltrials.gov database. Trials were categorized by their current status, study design, funding type, exclusion criteria, study phase, enrollment, start and completion dates, country of origin, item of investigation, outcome metrics, and whether a peer-reviewed publication was linked to the trial.

Querying the ClinicalTrials.gov registry yielded 196 trials, of which 161 (82.1 %) were started within the past 5 years. The average time to completion was 30.6 months. A total of 62 studies (31.6 %) examined the safety or efficacy of a thrombectomy device, 29 (14.8 %) investigated a pharmacological intervention alone or in combination with a device, 59 (30.1 %) examined aspects of the endovascular procedure on patient outcomes, and 14 (7.2 %) examined diagnostic utility during thrombectomy. Most trials were funded by academic centers (53.1 %) or industry (34.7 %). Although the United States contributed the most studies overall (59; 30.1 %), studies from European and Asian countries have been increasing since 2015.

These trends indicate an increasing number of trials starting the past few years, with most occurring in Europe and examining devices or aspects of the thrombectomy procedure.
These trends indicate an increasing number of trials starting the past few years, with most occurring in Europe and examining devices or aspects of the thrombectomy procedure.
Intracranial hemorrhage is a commonly encountered medical problem frequently evaluated by computed tomography angiography (CTA). In CTA, there is radiation exposure and possible adverse effects of intravenous contrast administration. Therefore, the yield of this diagnostic tool needs to be explored in a heterogeneous group of daily encountered patients to provide insight into the risks and benefits of CTA.

To evaluate the role of cerebral CTA in patients with CT-confirmed or clinically suspected intracranial hemorrhage.

This retrospective study included all patients who underwent cerebral CTA for evaluation of intracranial hemorrhage that was diagnosed by a plain CT scan or suspected clinically from January 1, 2010, to May 30, 2018. All the scans were evaluated for abnormalities of the cerebral arteries in the CTA.

One hundred twenty patients were included, 74 % were males, and the mean age was 46 years. Approximately 18 % were trauma patients. Overall, CTA was abnormal in 52 % of cases, aneurysms werTAs or showed CTA findings that were not relevant to the hemorrhage, clinical judgment should be exhausted before exposing them to radiation and intravenous contrast risks.Lignin modifying or extracellular enzymes secreted by the white rot fungi have the ability of degrading wide range of lignocellulosic substrates and organic pollutants. Lignocellulosic biomass, despite being a renewable source of energy, is difficult to hydrolyse (hydrolysis being rate-limiting stage in anaerobic digestion process). Various pre-treatment techniques like physical, chemical, thermo-chemical and biological to enhance the accessibility of microbes to carbohydrates have been studied. Recently, usage of white- rot fungi in a biological pre-treatment technique have received renewed interest due to its low cost and eco-friendly nature. This review deals with a) lignocellulosic biomass recalcitrance, b) various pre-treatment techniques and its economic feasibility, c) delignification and hydrolysis mechanism using white-rot fungi, d) factors controlling white-rot fungi pre- treatment process, and e) improvement in methane production through solid-state anaerobic digestion of white-rot fungi pre-treated lignocellulosic biomass.
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