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6 and p=0.065, x
=3.273). The sensitivity of traditional methods combined with NGS was as high as 82.4% (28/34).
NGS technology could rapidly detect the MTB complex in cerebrospinal fluid with significant sensitivity and specificity, which could be used as an early diagnosis index of TBM. NGS combined with MTB culture could increase the detection rate.
NGS technology could rapidly detect the MTB complex in cerebrospinal fluid with significant sensitivity and specificity, which could be used as an early diagnosis index of TBM. NGS combined with MTB culture could increase the detection rate.Peppermint oil (PO) is one of the most popular and widely used essential oils. However, due to volatile and poor water solubility of volatile oil, its application in the fields of medicine and food is limited. In order to solve this problem, the high speed shearing technology was used to prepare the nanoemulsion from PO. By using a series of characterization methods, such as turbiscan scanning spectrum, dynamic light scattering (DLS), confocal laser scanning microscope (CLSM), the best nanoemulsion formula was identified as PO 10 %, surfactant 8 % (Tween-60 EL-20 = 31) and deionized water 82 % (w/w). The inhibition strength of nanoemulsion on bacteria was evaluated by detecting the levels of reactive oxygen species (ROS) and malondialdehyde (MDA) in Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) treated with peppermint oil nanoemulsion (PON) and observing the morphology of bacteria with biological scanning electron microscope (SEM). The results showed that PON had strong inhibitory effect on E. coli. At the concentration range of 0.02 μg/μL-0.2 μg/μL, the apoptosis rate of BEAS-2B cells was less than 10 % compared with control cells. All in all, the PON prepared under this formula is stable, which provides a reference for further exploration of essential oil as natural antibacterial materials in the future.
The incidence of atrial fibrillation is increasing annually. We develop an automatic detection system, which is of great significance for the early detection and treatment of atrial fibrillation. This can lead to the reduction of the incidence of critical illnesses and mortality.
We propose an atrial fibrillation detection algorithm based on multi-feature extraction and convolutional neural network of atrial activity via electrocardiograph signals, and compare its detection based on cluster analysis, one-versus-one rule and support vector machine, using accuracy, specificity, sensitivity and true positive rate as evaluation criteria.
The atrial fibrillation detection algorithm proposed in this paper has an accuracy rate of 98.92%, a specificity of 97.04%, a sensitivity of 97.19%, and a true positive rate of 96.47%. The average accuracy of the algorithms we compared is 80.26%, and the accuracy of our algorithm is 23.25% higher than this average pertaining to the other algorithms.
We implemented an atrial fibrillation detection algorithm that meets the requirements of high accuracy, robustness and generalization ability. It has important clinical and social significance for early detection of atrial fibrillation, improvement of patient treatment plans and improvement of medical diagnosis.
We implemented an atrial fibrillation detection algorithm that meets the requirements of high accuracy, robustness and generalization ability. It has important clinical and social significance for early detection of atrial fibrillation, improvement of patient treatment plans and improvement of medical diagnosis.
COVID-19 progresses slowly and negatively affects many people. However, mild to moderate symptoms develop in most infected people, who recover without hospitalization. Therefore, the development of early diagnosis and treatment strategies is essential. One of these methods is proteomic technology based on the blood protein profiling technique. This study aims to classify three COVID-19 positive patient groups (mild, severe, and critical) and a control group based on the blood protein profiling using deep learning (DL), random forest (RF), and gradient boosted trees (GBTs).
The dataset consists of 93 samples (60 COVID-19 patients, 33 control), and 370 variables obtained from an open-source website. The current dataset contains age, gender, and 368 protein, used to predict the relationship between disease severity and proteins using DL and machine learning approaches (RF, GBTs). An evolutionary algorithm tunes hyperparameters of the models and the predictions are assessed through accuracy, sensitivity, specificity, precision, F1 score, classification error, and kappa performance metrics.
The accuracy of RF (96.21%) was higher as compared to DL (94.73%). However, the ensemble classifier GBTs produced the highest accuracy (96.98%). CIL56 clinical trial TGB1BP2 in the cardiovascular II panel and MILR1 in the inflammation panel were the two most important proteins associated with disease severity.
The proposed model (GBTs) achieved the best prediction of disease severity based on the proteins compared to the other algorithms. The results point out that changes in blood proteins associated with the severity of COVID-19 may be used in monitoring and early diagnosis/treatment of the disease.
The proposed model (GBTs) achieved the best prediction of disease severity based on the proteins compared to the other algorithms. The results point out that changes in blood proteins associated with the severity of COVID-19 may be used in monitoring and early diagnosis/treatment of the disease.
This paper reports a quantitative analysis of the effects of joint photographic experts group (JPEG) image compression of retinal fundus camera images on automatic vessel segmentation and on morphometric vascular measurements derived from it, including vessel width, tortuosity and fractal dimension.
Measurements are computed with vascular assessment and measurement platform for images of the retina (VAMPIRE), a specialized software application adopted in many international studies on retinal biomarkers. For reproducibility, we use three public archives of fundus images (digital retinal images for vessel extraction (DRIVE), automated retinal image analyzer (ARIA), high-resolution fundus (HRF)). We generate compressed versions of original images in a range of representative levels.
We compare the resulting vessel segmentations with ground truth maps and morphological measurements of the vascular network with those obtained from the original (uncompressed) images. We assess the segmentation quality with sensitivity, specificity, accuracy, area under the curve and Dice coefficient.
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