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Hence, the E. coli BL21 (DE3) cells have the potential to produce MHETase proteins for the plastic degradation testing process. Other This study was financially supported by Hibah Riset ITB 2019. Copyright© Bentham Science Publishers; For any queries, please email at [email protected] belong to the genus Vaccinium of the family Ericaceae. Rapidly accumulating experimentally verified data is uncovering tremendous pharmacological properties of biologically active constituents of Blueberries against different diseases. Our rapidly evolving knowledge about multifaceted nature of cancer has opened new horizons to search for different strategies to target multiple effectors of oncogenic networks to effectively inhibit cancer onset and progression. Excitingly, Whole blueberry powder and various bioactive constituents (Pterostilbene, malvidin-3-galactoside) of Blueberries have been shown to efficiently inhibit metastasis in animal models. These results are encouraging and future studies must converge on identification of cell signaling pathways effectively modulated by Blueberries in different cancers. It seems exciting to note that researchers are focusing on metastasis inhibitory effects of Blueberry, however, to reap full benefits it is necessary to take a step back and critically re-interpret the mechanisms used by active components of Blueberry to inhibit or prevent metastasis. Overview of the existing scientific evidence revealed visible knowledge gaps and better understanding of the targets of Blueberry will be helpful in efficient and meaningful translation of laboratory findings to clinically effective therapeutics. Copyright© Bentham Science Publishers; For any queries, please email at [email protected] Compounds containing furo[3,2-b]pyridine framework have shown interesting pharmacological properties including anticancer activities. Though these compounds are generally synthesized via the heteroannulation processes involving acetylenic derivatives some of them are not straightforward. OBJECTIVE To explore a series of 2-substituted furo[3,2-b]pyridines for their cytotoxic properties against cancer cell lines in vitro. METHODS We have developed a convenient synthesis of 2-substituted furo[3,2-b]pyridines via sequential (i) C-C coupling followed by (ii) C-O bond forming reactions in a single pot. The reactions were performed under ultrasound irradiation in the presence of Pd/C as an inexpensive, stable and widely used catalyst. A range of 2-substituted furo[3,2-b]pyridines were synthesized via coupling of 3-chloro-2-hydroxy pyridine with terminal alkynes in the presence of 10% Pd/C-CuI-PPh3-Et3N in EtOH. The in vitro evaluation of all these compounds was carried out against MDAMB-231 and MCF-7 cell lines and subsequently against SIRT1. RESULTS The furo[3,2-b]pyridine derivative 3b showed encouraging growth inhibition of both MDAMB-231 and MCF-7 cell lines and inhibition of SIRT1. The compound 3b also showed apoptosis inducing potential when tested against MCF-7 cells. CONCLUSION The Pd/C-Cu catalysis under ultrasound accomplished a one-pot and direct access to 2-substituted furo[3,2-b]pyridine derivatives some of which showed anticancer properties. Copyright© Bentham Science Publishers; For any queries, please email at [email protected] Nowadays the use of plant-derived products has been extensively examined in the treatment of many types of gastrointestinal cancer such as hepatocarcinoma and colon cancer. Urtica dioica is a traditional herb that has many pharmacological effects and wildly used as a therapeutic agent in cancer. Herein, we have evaluated the effects of the different concentrations of Methanolic Extract of Urtica dioica (MEUD) on viability, death pattern, and expression of the apoptosis-related gene in normal Human Dermal Fibroblast (HDF), hepatocarcinoma cell lines (HepG2) and colon-cancer cell line (HCT116). METHODS A high-performance liquid chromatography method was developed to simultaneously separate 3 phenolic acids in MEUD. HepG2 and HCT116 cell lines as well as HDF normal cell line were cultured in suitable media. After 24 and 48h, cultured cell with different concentrations of MEUD, Cells viability was assessed by MTT assay, and apoptosis was also evaluated at the cellular level by Annexin V/PI flowcytometry analyzing and AO/EB staining. BCL2 and BAX gene expression were assessed by TaqMan real-time PCR assay. RESULTS MEUD showed antiproliferative effects on HepG2 and HTC116 cells after 48h with an IC50 value of about 410 and 420μg/ml, respectively (P less then 0.001). Apoptotic cells were observed in HepG2 and HTC116 cells but not in HDF. Furthermore, the increased level of BAX/BCL-2 ratio was observed in HepG2 and HTC116 cells under the treatment of different concentrations of MEUD Conclusions The MEUD may influence hepatocarcinoma and colon-cancer cell lines at specific doses and change their proliferation rate by changing the expression of BAX and BCL2. https://www.selleckchem.com/products/ve-822.html Copyright© Bentham Science Publishers; For any queries, please email at [email protected] cells are the undifferentiated cells in the body that possess the ability to differentiate and give rise to any type of cell in the body. In recent years, there has been a growing interest in therapy involving the stem cells as different treatment methods got developed. Depending on the source, there are two major kinds of stem cells, embryonic and adult stem cells. The former type is found in the embryo at the different developmental stages before the implantation and excels the latter owing to pluripotency. On the premise of the attributes of stem cells, they are touted as the "panacea for all ills" and are extensively sought for their potential therapeutic roles. There is a lot of robust pieces of evidence that have proved to cure the different ailments in the body like Huntington disease, Parkinson's disease, and Spinal cord injury with stem cell therapy but associated adverse effects like immune rejection and teratoma formation are well-known. In this regard, the pre-morula (isolated at an early pre-morula stage) stem cells (PMSCs) are one of its kind of embryonic stem cells that are devoid of the aforementioned adverse effects.
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