Notes

Impact involving DICER1 as well as DROSHA around the Angiogenic Ability of Human Endothelial Cellular material.
Attention deficit hyperactivity disorder (ADHD) is a high-prevalence condition an estimated 2-4% of adults have it. For its diagnosis it is important to know both the presence of symptoms in the present and during the childhood, for which self-administered tools are a valuable resource.

Validate the ASRS and WURS25 scales (abbreviated version of the WenderUtah scale) in Argentine population, as well as provide norms for their application.

A general population sample of 1173 volunteers recruited from the internet was used, as well as a clinical sample of 80 patients with ADHD, both completed the scales and a sociodemographic questionnaire. Statistical studies were conducted to verify the internal validity and factorial consistency of the ASRS subscales (corresponding to inattention, hyperactivity and combined) and the two samples were compared to assess the external validity of the test.

The data obtained showed statistical behavior like the original versions of the tests, adequate levels of internal consistency and clinical discrimination. There were no significant differences depending on the gender of the participants or by age in subjects aged 18 to 50 years. However, subjects over the age of 50 scored higher in the ASRS.

The ASRS and the WURS-25 meet the expected internal consistency and external validity criteria in the Argentine population.
The ASRS and the WURS-25 meet the expected internal consistency and external validity criteria in the Argentine population.
The neuropsychological profile of patients with mild cognitive impairment (MCI) has been the target of several investigations. However, few works have been published about the language profile in these patients.

To analyse and integrate the published scientific literature about this topic after the systematic review carried out by Johnson and Lin in 2014.

A systematic review was carried out in which three databases (Web of Science, PubMed and PsycInfo) were consulted. Seventeen studies have been analysed, with adult participants diagnosed with MCI, that included at least one control group, and studies that evaluated language parameters. A self-made registration protocol has been applied to encode the characteristics and results of the studies; and the quality of the studies and articles has been evaluated through a self-elaboration scale based on previously validated instruments.

Patients with MCI can present deficits in naming, speech production, oral comprehension, and written comprehension.

It is important to evaluate language in patients with MCI, although this exploration does not allow establishing a diagnosis on by itself. However, the pathology variability associated with the diagnosis, the age, the language, and the educational level of the participants, as well as the sample size, and the instruments and measures used to evaluate the language in the studies reviewed, make impossible to obtain a conclusive statement, so further research about this topic is needed.
It is important to evaluate language in patients with MCI, although this exploration does not allow establishing a diagnosis on by itself. However, the pathology variability associated with the diagnosis, the age, the language, and the educational level of the participants, as well as the sample size, and the instruments and measures used to evaluate the language in the studies reviewed, make impossible to obtain a conclusive statement, so further research about this topic is needed.A few decades ago, the understanding of the pathophysiological processes involved in the coronary artery thrombus formation has placed anticoagulant and antiplatelet agents at the core of the management of acute coronary syndrome (ACS). Increasingly potent antithrombotic agents have since been evaluated, in various association, timing, or dosage, in numerous randomized controlled trials to interrupt the initial thrombus formation, prevent ischemic complications, and ultimately improve survival. Primary percutaneous coronary intervention, initial parenteral anticoagulation, and dual antiplatelet therapy with potent P2Y12 inhibitors have become the hallmark of ACS management revolutionizing its prognosis. Despite these many improvements, much more remains to be done to optimize the onset of action of the various antithrombotic therapies, for further treating and preventing thrombotic events without exposing the patients to an unbearable hemorrhagic risk. The availability of various potent P2Y12 inhibitors has opened the door for individualized therapeutic strategies based on the clinical setting as well as the ischemic and bleeding risk of the patients, while the added value of aspirin has been recently challenged. The strategy of dual-pathway inhibition with P2Y12 inhibitors and low-dose non-vitamin K antagonist oral anticoagulant has brought promising results for the early and late management of patients presenting with ACS with and without indication for oral anticoagulation. In this updated review, we aimed at describing the evidence supporting the current gold standard of antithrombotic management of ACS. More importantly, we provide an overview of some of the ongoing issues and promising therapeutic strategies of this ever-evolving topic.Sepsis is a life-threatening complication of infection closely associated with coagulation abnormalities. find more Heat shock factor 1 (HSF1) is an important transcription factor involved in many biological processes, but its regulatory role in blood coagulation remained unclear. We generated a sepsis model in HSF1-knockout mice to evaluate the role of HSF1 in microthrombosis and multiple organ dysfunction. Compared with septic wild-type mice, septic HSF1-knockout mice exhibited a greater degree of lung, liver, and kidney tissue damage, increased fibrin/ fibrinogen deposition in the lungs and kidneys, and increased coagulation activity. RNA-seq analysis revealed that tissue-type plasminogen activator (t-PA) was upregulated in the lung tissues of septic mice, and the level of t-PA was significantly lower in HSF1-knockout mice than in wild-type mice in sepsis. The effects of HSF1 on t-PA expression were further validated in HSF1-knockout mice with sepsis and in vitro in mouse brain microvascular endothelial cells using HSF1 RNA interference or overexpression under lipopolysaccharide stimulation.
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