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ITQ-69: A new Germanium-Containing Zeolite and its particular Combination, Construction Perseverance, as well as Adsorption Properties.
BACKGROUND The availability of direct oral anticoagulants (DOAC) in clinical practice has transformed the health care provided to patients for the prevention and treatment of thromboembolism. Safety and efficacy data guide clinicians in the choice of the drug used. To date, no evidence is available from head-to-head trials comparing different DOAC with regard to safety and efficacy; information is mainly derived from several meta-analyses and real-life studies. Conclusions from these studies are inconsistent and unsatisfactory. The evaluation of self-reported adverse drug reactions (ADR) available from databases of drug-regulatory agencies such as the Italian Medicines Agency (AIFA) pharmacovigilance database represents a novel aid to guide decision-making. OBJECTIVE To analyze potential suspected ADR of DOAC using a previously described risk index (RI) in daily clinical practice in Italy. METHODS The National Pharmacovigilance Network database (from the AIFA website) was searched in order to retrieve information on all ADR related to oral anticoagulants occurring from 2013 to 2018. The ADR RI for each drug was calculated, where an RI = 1 indicates a balance between the percentage of ADR share and the percentage of market share for each DOAC; and an RI less then 1 indicates a rate of ADR lower than the rate of market share (safer DOAC). The following DOAC molecules were considered dabigatran, rivaroxaban, apixaban, and edoxaban. RESULTS The results showed that rivaroxaban is the DOAC with the lowest RI among the 4 molecules available today in Italy. CONCLUSIONS Based on the RI, we identified rivaroxaban as the DOAC having the best safety profile. © 2020 S. Karger AG, Basel.Materials science is nowadays facing challenges in optimizing properties of materials which are needed for numerous technological applications and include, but are not limited to, mechanics, electronics, optics, etc. buy Apabetalone The key issue is that for emerging applications materials are needed which incorporate certain properties from polymers or biopolymers and metals or ceramics at the same time, thus fabrication of functional hybrid materials becomes inevitable. Routes for the synthesis of functional hybrid materials can be manifold. Among the explored routes vapor phase processing is a rather novel approach which opts for compatibility with many existing industrial processes. This topical review summarizes the most important approaches and achievements in the synthesis of functional hybrid materials through vapor phase routes with the goal to fabricate suitable hybrid materials for future mechanical, electronic, optical or biomedical applications. Most of the approaches rely on atomic layer deposition (ALD) and techniques related to this process, including molecular layer deposition (MLD) and vapor phase infiltration (VPI), or variations of chemical vapor deposition (CVD). The thus fabricated hybrid materials or nanocomposites often show exceptional physical or chemical properties, which result from synergies of the hybridized materials families. Even though the research in this field is still in its infancy, the initial results encourage further development and promise great application potential in a large variety of applications fields such as flexible electronics, energy conversion or storage, functional textile, and many more. Creative Commons Attribution license.The low-temperature electrical transport properties of the rare-earth (RE) Ce, Dy, Sm element doped Fe2VAl Heusler alloys have been investigated. A significant enhancement in the Seebeck coefficient S (peak values of about -125 to -160 µV/K) is observed as compared to the pure Fe2VAl (peak value of about 40 µV/K). It is observed that the thermal conductivity reduced by 50% in RE-doped samples. The single parabolic band model (SPB) has been used to analyze the experimental data and to understand the role of fundamental parameters like the Lorenz number. The lattice contribution to the total thermal conductivity was analyzed through the Callaway model, which in turn provided the insight into the phonon scattering in these alloys. Finally, we demonstrate a significant improvement in power factor and figure of merit at all temperatures for the RE-doped Fe2VAl alloys. © 2020 IOP Publishing Ltd.An out. © 2020 IOP Publishing Ltd.Polar phonon modes associated with room temperature ferroelectricity are observed in SrTiO3 single crystals irradiated with Ti ions. Quantitative strain analysis reveals that irradiation-induced out-of-plane strain drives the centrosymmetric cubic SrTiO3 to a tetragonal-like structure in the maximum damaged region. Energy transfer from ions to electrons during ion irradiation yields defects in SrTiO3 that also plays an important role for the room temperature ferroelectricity. Different from thin film techniques, the ferroelectricity in the ion irradiated SrTiO3 can occur for much larger thicknesses, depending on the energy and type of ion. © 2020 IOP Publishing Ltd.Colorimetric sensing methods based on non-spherically symmetric gold nanoparticles have become a powerful tool in the field of biomedical detection because of the intriguing plasmonic properties. In this study, gold nanobipyramids (Au NBPs) were used as colorimetric sensing probes to detect ferrous ions (Fe2+) through tip etching. As Au NBPs were quickly etched along the longitudinal direction by superoxide radicals generated by the reaction of Fe2+ and H2O2, it leaded local surface plasmon resonance (LSPR) to blue shift and produced vivid color change that could be used for visual inspection. Under the optimal reaction conditions, the peak shift of Au NBPs and the logarithm of the concentrations of Fe2+ had linear relationship in range of 10 nM to 10 μM with a very low detection limit of 1.29 nM. During the etching process, different end shape of gold nanoparticles results in different process of the morphology transition, which makes the degree of spectral change and detection sensitivity significantly different. So, in the presence of trace amounts of Fe2+ ( less then 1000 nM), the detection sensitivity of Au NBPs with sharp ends which rely on aspect ratio and truncation is 9 times higher than that of gold nanorods with round ends which only rely on aspect ratio. Although the color change of larger-sized Au NBPs was not clear during detection, the LSPR peak shift was more severe. Therefore, the system provides different modes for detecting Fe2+ according to Au NBPs which has different sizes and characteristics. © 2020 IOP Publishing Ltd.
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