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Digestive shipping and also contractility in diabetic person bowel problems: A radio mobility supplement study on diabetics as well as healthy handles.
OBJECTIVES Gastrointestinal (GI) system is commonly affected in sytemic sclerosis (SSc) patients who are also known to be at risk for malnutrition. We aimed to investigate the relationship between severity of GI disease, malnutrition and severity of organ involvement including microvasculopathy. METHODS A hundred and thirty-four SSc patients were included into the study; disease activity and severity, the University of California, Los Angeles, Scleroderma Clinical Trials Consortium Scleroderma Gastrointestinal scale 2.0 (UCLA SCTC GIT 2.0) and malnutrition universal screening tool (MUST) were cross-sectionally assessed. Nailfold video-capillaroscopy(NVC) was performed to evaluate microvasculopathy. RESULTS SSc patients who are at medium to high risk for malnutrition (n=20); had more frequently limited pulmonary function, lung involvement, pulmonary hypertension, capillary rarefaction and NVC late pattern than those at low risk for malnutrition. Capillary rarefaction (≤6/mm) was shown to be independently associated with medium to high risk for malnutrition defined by using MUST. BSO inhibitor Capillary rarefaction and severe skin involvement were found to be independently related to 'severe' or 'very severe' GI disease defined by using UCLA SCTC GIT 2.0. UCLA SCTC GIT 2.0 scores were not found to be good discriminative in patients at risk for malnutrition allowing for a ROC curve of area under the curve (AUC) less then 0.8). CONCLUSIONS Assessment of gastrointestinal complaints and nutritional status by using symptom based questionnaires reflected the severity of GI disease and malnutrition including some limitations. Capillary rarefaction and severe skin involvement might be determining factors for malnutrition risk and severe GI disease.OBJECTIVES The collagen-induced arthritis (CIA) model shares both immunological and pathological features with human rheumatoid arthritis (RA), thus it has been used extensively as a model to study the pathogenesis of RA and for testing therapeutics. It is well-known that the T helper cell 17 (Th17) responses are involved in the pathogenesis of RA, while the regulatory T cells (Tregs) are considered to limit the progress of disease. Previously, we found that peritoneal cells (PCs) possess immunosuppressive characteristics and it is conceivable that PCs potentially have the therapeutic benefits for RA. In this study, we investigated whether PCs are capable of Treg induction and therefore suppress Th17-mediated CIA. METHODS Naïve PCs were intravenously transferred into CIA mice at the early clinical signs of arthritis. The treatment commenced on day 0 and then every other day until day 14. Clinical symptoms of arthritis, histological changes, cytokine expressions and cell population profiles were investigated. RESULTS Intravenously administrating PCs ameliorated the severity of CIA. Further investigations unveiled that the reduction of Th17 cells and the induction of Tregs is ascribed to the remission of the disease. Specifically, when splenic PBMC were cultured with PCs, the expression of FOXP3 and IFN-γ was markedly induced. It is suggested that IFN-γ secreted by PCs plays an important role in the conversion of CD4+T cells to Tregs. CONCLUSIONS The adoptive transfer of PCs is effective in the treatment of CIA by regulating the T cell differentiations. Our findings might provide a new strategy for RA therapy.OBJECTIVES It has been proved that fibroblast-like synoviocytes (FSs) play a critical role in the course of rheumatoid arthritis (RA), is a systemic autoimmune disease affecting multiple joints. Until now, no effective treatment has been established. Long non-coding RNA Growth Arrest-Specific Transcript 5 (GAS5) has been identified as a tumour-suppressor lncRNA in various cancers. However, the expression, biological role and clinical significance of GAS5 in RA is completely unknown. In this study, we test the hypothesis that GAS5 might inhibit proliferation and inflammatory response of FSs in RA. METHODS The expression of GAS5 was examined in synovial tissues from RA patients and normal individuals. RESULTS The expression of GAS5 was significantly reduced in RA synovial tissues and RA FSs, whereas the expression of homeodomain-interacting protein kinase 2 (HIPK2) was increased, indicating that it plays a critical role in inflammation and autoimmune diseases. We found that overexpression of GAS5 decreased the level of HIPK2, TNF-α and IL-6. CONCLUSIONS The methylation-specific PCR results suggested that the GAS5 gene promoter was significantly methylated in RA synovial tissues and RA FSs. More importantly, treatment with methylation inhibitor 5-aza-2-deoxycytidine (5-azadC) inhibited hypermethylation of GAS5 promoter and expression of HIPK2. These results indicated that GAS5 regulates RA via potentially targeting HIPK2. Therefore, this study may provide a potential therapeutic target for RA.OBJECTIVES Polymyalgia rheumatica (PMR) is characterised by inflammatory pain of shoulders and the pelvic girdle that affects older people. Conditions that can mimic PMR include rheumatoid arthritis (RA), spondyloarthritis (SpA) and calcium pyrophosphate disease (CPPD). In this study, we aimed to define the prevalence of CPPD among patients with polymyalgic syndrome with suspected PMR according to recent ACR/EULAR criteria. METHODS This was an observational study in which we included patients with polymyalgic syndrome (inflammatory pain of shoulders, elevated C-reactive protein (CRP) level, and age >50 years). All patients were tested for RA antibodies and underwent ultrasonography (US) of shoulders [gleno-humeral effusion, biceps tenosynovitis, sub-acromiodeltoid (SAD) bursitis, synovitis and CPPD of the acromio-clavicular (AC) joint and humeral bone erosion]. RESULTS We included 94 patients with polymyalgic syndrome (mean age 69.4±11.3 years, 67% female); 27 had a diagnosis of RA and 14 SpA. The remaining 52 were considered to have PMR according to ACR/EULAR criteria for PMR; 25 had a diagnosis of CPPD. As compared with PMR patients without CPPD, those with CPPD more frequently had humeral bone erosion (p=0.003), synovitis and CPPD of the AC joint (p less then 0.0001 for both) and less frequently SAD bursitis (p=0.0098). For PMR diagnosis, the most sensitive US features were SAD bursitis (96.3%) and biceps tenosynovitis (85.2%), despite low specificity. For CPPD diagnosis, CPPD of the AC joint had the best ratio of sensitivity to specificity (sensitivity 85.2%; specificity 97.1%). CONCLUSIONS Detection of CPPD is relatively frequent with suspected PMR. Adding US assessment of the AC joint to usual US screening might help the clinician better distinguish PMR from other conditions, notably CPPD.
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