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The majority of psoriatic arthritis (PsA) patients present at dermatology clinics with cutaneous psoriasis up to 10 years prior to arthritis onset; therefore, applying a suitable screening tool to detect PsA early is essential for dermatologists. This study aimed to validate and evaluate the Persian version of two PsA screening questionnaires, the early arthritis for psoriatic patients questionnaire (EARP) and the psoriasis epidemiology screening tool (PEST) in Iranian psoriatic patients.

In this cross-sectional study, psoriatic patients who presented to the dermatology clinic without a previously established PsA were asked to fill out the Persian version of EARP and PEST. PsA was diagnosed by a rheumatologist based on the fulfillment of the classification criteria for psoriatic arthritis. Receiver operator characteristic (ROC) curves, sensitivity, and specificity were calculated for both questionnaires.

A total of 75 patients (33 [44%] female, 42 [56%] male, with a mean age of 43.2 ± 14.6) were enrolled in the study. The prevalence of PsA based on rheumatologist diagnosis was 25.3% (19 patients had PsA). The ROC curve analysis of EARP and PEST were 0.949 (95% CI 0.897–1) and 0.922 (95% CI 0.834–1). The sensitivity of EARP and PEST questionnaires was 94.7% and 58%, respectively, while the specificity was 78.6% and 96.4%, respectively, with a cut-off of 3.

The Persian version of both questionnaires showed good performance. We suggest EARP as a screening tool for PsA in the dermatology clinics due to much higher sensitivity with acceptable specificity compared to PEST.
The Persian version of both questionnaires showed good performance. We suggest EARP as a screening tool for PsA in the dermatology clinics due to much higher sensitivity with acceptable specificity compared to PEST.Not required.
Fatigue is very common symptom in patients with systemic sclerosis (SSc) and adversely affects health-related quality of life and the ability to perform daily living activities. This study aims to determine the severity of fatigue and its related factors in patients with SSc.

A total of 35 patients with SSc (6 males / 29 females, mean age 50.71 ± 10.09 years) and 35 healthy control subjects (8 males / 27 females, mean age 54.14 ± 9.51 years) were included. The Fatigue Impact Scale for fatigue, Modified Medical Research Council Scale for dyspnea severity, 6-Minute Walking Test for functional capacity, Health Assessment Questionnaire Disability Index, Scleroderma Health Assessment Questionnaire and Short Form-36 Quality of Life Questionnaire for health-related quality of life were used in subjects?

Furthermore, pulmonary functions, diffusion capacity, respiratory and peripheral muscle strength were evaluated.

Eighty percent of the SSc patients experienced fatigue and represented higher total and cognitiom the early period in SSc patients.
Along with the decrease in diffusion capacity, increase dyspnea, a decrease in both peripheral and respiratory muscle strength and worsening functional capacity may have an effect on increased fatigue in SSc patients. Increased fatigue can also affect patients' life quality and daily life activities. Therefore, we recommend multidisciplinary approaches to evaluate and improve these parameters in the treatment of fatigue from the early period in SSc patients.
Graft-versus-host disease (GVHD) is a crucial complication leading to significant morbidity and mortality allogeneic hematopoietic stem cell transplantation which occurs in approximately half of the transplant recipients. Suppression of tumorigenicity 2 (ST2) and regenerating islet-derived 3-alpha(Reg3a) might be important biomarkers to predict acute GVHD.

In the present study, blood samples were collected from 17 patients with acute GVHD and 12 control patients after allogeneic stem cell transplantation. ST2 and Reg3a were measured in plasma samples compared in patients with acute GVHD and the controls.

Median age of the study population was 42 years (range 19–49). When compared to controls, the mean ST2 levels was significant higher in acute GVHD (9794 ng/dL vs. 2646 ng/dL, P = 0.008). Mean Reg3a level did not show significant difference between control and acute GVHD group (8848 ng/dL vs. 5632 ng/dL, respectively, P = 0.190).

The ST2 level might be used as a significant biomarker for predicting acute GVHD.
The ST2 level might be used as a significant biomarker for predicting acute GVHD.Background/Aim Most of the hospitalized patients are on a number of drugs for comorbidities and/or to prevent nosocomial infections. This necessitates a careful consideration of drug interactions not only to avoid possible toxicities but also to reach the highest efficiency with drug treatment. ML265 ic50 We aimed to investigate drug interactions related to systemic antibiotic use and compare three different databases to check for drug interactions while characterizing main differences between medical and surgical departments. Materials and Methods This point prevalence study covered data on 927 orders for patients hospitalized June 3-10, 2018 in Ankara University Hospitals. Systemic antibiotic use and related drug interactions were documented by utilizing UptoDate, Drugs and Medscape and compared between departments of medical and surgical sciences. Results The number of orders, drugs or antibiotics per order were not different between medical and surgical sciences departments. A total of 1335 antibiotic-related drug interactions of all levels were reported by one, two or all three databases. UptoDate reported all common and major interactions. Pantoprazole was the most commonly prescribed drug and appeared in 63% of all orders. Among 75 different molecules, ceftriaxone and meropenem were the two most prescribed antibiotics by surgical and medical departments, respectively. Conclusions A dramatic variance existed amongst antibiotics prescribed by different departments. This indicated indicated the requirement for a centralized role of an infectious diseases specialist. Especially for the hospitalized patient, prophylactic coverage with at least one antibiotic brought about a number of drug interactions. A precise evaluation by a clinical pharmacist -currently none on duty- of orders in terms of drug interactions will reduce possible drug-related hazards.
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