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NLRP3 Inflammasome Inhibitors within Cardiovascular Diseases.
The purpose of this study was to compare the absorbed dose distributions within the heart and lad in patients with left-sided breast cancer who underwent radiotherapy using 3D-CRT, IMRT and VMAT techniques.

The treatment plans of 11 patients with left-sided breast cancer were analyzed. All of the patients were irradiated in our facility with DIBH 3D-CRT. For all patients the plans in the IMRT (sliding window) and VMAT (Rapid Arc - Varian) techniques were prepared. Cumulative dose-volume histograms (DVH) were used to compare the dose distributions between the plans for each patient. Statistical analysis was carried out using the one-way ANOVA with repeated measurements and Tukey's post hoc test.

The use of IMRT and VMAT techniques allowed for a better coverage of the PTV with 95% isodose and a more homogeneous dose distribution compared to the 3D-CRT technique. The use of dynamic technique (IMRT or VMAT) did not provide significant protection for OARs - only the dose absorbed in LAD was slightly lower.

The use of 3D-CRT allows better protection of critical organs compared to other techniques, except for the dose in the lad artery which was the lowest in IMRT technique. exposure of large tissue volumes to so-called low radiation doses is undoubtedly a disadvantage of using dynamic techniques.
The use of 3D-CRT allows better protection of critical organs compared to other techniques, except for the dose in the lad artery which was the lowest in IMRT technique. exposure of large tissue volumes to so-called low radiation doses is undoubtedly a disadvantage of using dynamic techniques.
Mutations of the PI3K/AKT/mTOR signaling pathway occur in 70% of all breast cancers and represent a clinically useful marker for disease prognosis and patient management. The purpose of this work was to study the main somatic PIK3CA gene mutations in breast cancer patients and the search for a relationship with the main clinical and pathological characteristics and the effect of neoadjuvant chemotherapy (NAC).

The study involved 29 patients with luminal B breast cancer. DNA was isolated from samples of tumor tissue before and after treatment using the QIAamp DNA mini Kit (Qiagen, Germany). Samples were prepared for sequencing by amplification with primers containing TruSeq index and adapter sequences (Illumina, USA) using Encyclo polymerase.

We found 5 different somatic changes in 28% of patients c.3140A> G (p.His1047Arg), c.3140A> T (p.His1047Leu), c.1624G> A (p.Glu542Lys), c.1633G> A ( p.Glu545Lys), c.3145G> C (p.Gly1049Arg). In the group of patients with mutations, 50% showed PIK3CA gene amplifications. click here The c.3140A> T (p.His1047Leu) mutation was associated with low disease-free survival rates. PIK3CA gene mutations were observed in 38% of patients with HER2-subtype, and metastasis-free survival rates were, on average, 1.5 times higher than in patients with normal gene status.
T (p.His1047Leu) mutation was associated with low disease-free survival rates. PIK3CA gene mutations were observed in 38% of patients with HER2-subtype, and metastasis-free survival rates were, on average, 1.5 times higher than in patients with normal gene status.
Potential influences of GRK5 polymorphism on cancer risks have been reported. This study aimed to explore the distribution of GRK5 genotypes and alleles in Chinese breast cancer (BCa) patients, and to analyze the association between GRK5 and BCa risk.

Blood samples were collected from 412 BCa patients and 533 healthy individuals for isolating genomic DNA. GRK5 polymorphisms of Gln41Leu A > T and Arg304His G > A, and their alleles were detected using PCR-RFLP. Their influences on BCa susceptibility and pathological indexes were analyzed using Logistic regression model.

No significant differences in age, body mass index (BMI) and smoking status were found between BCa patients and healthy persons, while significant differences were detected in drinking status, family history of cancer, hypertension and diabetes. GRK5Gln41Leu A > T and its allele frequency distribution were correlated to BCa susceptibility, while GRK5 Arg304His G > A was not. Higher risks of GRK5 Gln41Leu A > T and Arg304His G > A indicated a higher susceptibility to BCa. Compared with people carrying 0-1 risk allele, those carrying 2-4 risk alleles of GRK5 Gln41Leu A > T and Arg304His G > A of had a higher susceptibility to BCa, manifesting as worse tumor staging and grading, and higher rates of estrogen receptor (ER) (-), progesterone receptor (PR) (-) and HER2 (-).

Gln41Leu A > T and Arg304His G > A fusion gene polymorphisms of GRK5 are vital genetic susceptibility genes to BCa. Our findings require to be validated in a multicenter study with a high-quality large sample size.
 A fusion gene polymorphisms of GRK5 are vital genetic susceptibility genes to BCa. Our findings require to be validated in a multicenter study with a high-quality large sample size.
The purpose of this study was to investigate the efficacy and safety of maintenance therapy of capecitabine metronomic chemotherapy combined with autologous cytokine-induced killer (CIK) cell immunotherapy in patients with recurrent metastatic triple-negative breast cancer (mTNBC).

The clinical data of 110 patients with recurrent mTNBC were retrospectively analyzed. Among, 55 were treated with maintenance therapy of capecitabine metronomic chemotherapy combined with autologous CIK cell immunotherapy (DC-CIK group), while the rest 55 were treated with simple metronomic chemotherapy (control group).

The ORR of patients in DC-CIK group and control group was 29.1% and 16.4%, and the DCR was 74.5% and 63.6%, respectively. After treatment, the proportions of CD3+ T lymphocytes, CD4+ T lymphocytes and NK cells as well as the CD4/CD8 cell ratio were notably higher in DC-CIK group than those in control group, while the proportion of CD8+ T lymphocytes was notably lower in DC-CIK group than that in control group. patients' immune function, improve their quality of life, and prolong their PFS. Key words capecitabine, metronomic chemotherapy, immunotherapy, breast cancer, recurrent and metastatic.
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