Notes

CD209L/L-SIGN along with CD209/DC-SIGN Become Receptors regarding SARS-CoV-2.
Climate change can have an adverse effect on agricultural productivity and water availability in semi-arid regions, as changes in surface water availability lead to groundwater depletion and resultant losses in crop yield. These inter-relationships necessitate an integrated management approach for surface water, groundwater, and crop yield as a holistic system. This study quantifies the future availability of surface water and groundwater and associated crop production in a large semi-arid agro-urban river basin in which agricultural irrigation is a leader consumer of water. The region of study is the South Platte River Basin (72,000 km2), Colorado, USA. The coupled SWAT-MODFLOW modeling code is used as the hydrologic simulator and forced with five different CMIP5 climate models downscaled by Multivariate Adaptive Constructed Analogs (MACA), each for two climate scenarios, RCP4.5, and RCP8.5, for 1980-2100. The hydrologic model accounts for surface runoff, soil lateral flow, groundwater flow, groundwater-surface water interactions, irrigation from surface water and groundwater, and crop yield on a per-field basis. In all climate models and emission scenarios, an increase of 3 to 5 °C in annual average temperature is projected. Whereas, variation in the projected precipitation depends on topography and distances from mountains. Based on the results of this study, the worst-case climate model in the basin is IPSL-CM5A-MR-8.5. Under this climate scenario, for a 1 °C increase in temperature and the 1.3% reduction in annual precipitation, the basin will experience an 8.5% decrease in stream discharge, 2-5% decline in groundwater storage, and 11% reduction in crop yield. These results indicate the significant effect of climate change on water and food resources of a large river basin, pointing to the need for immediate implementation of conservation practices.Air-cathode microbial fuel cells (ACMFCs) can extract available electrons from the low C/N ratio wastewater (LCNW) for pollutant degradation and power generation. However, the multiple effects of operating parameters and their relationship between the performances and parameters are still lacking. In this study, several ACMFCs for simultaneous nitritation/denitritation (SND) and energy recovery were constructed and evaluated in terms of chemical oxygen demand (COD), NH4+-N, C/N ratio, phosphate buffer solution (PBS), and external resistance (Rext), and several derived parameters (e.g., organic loading rate (OLR), nitrogen loading rate (NLR)). Results indicated that ACMFCs could be used to treat LCNW successfully with high pollutant removal rates and sustainable current generation. Maximum removal efficiencies of 94% COD, 92% NH4+-N, and 92% total nitrogen (TN) were achieved. A maximum power density of 1400 mW m-2 and columbic efficiency of 69.2% were also obtained at a low C/N ratio of 1.7-2.6. Low C/N ratios promoted SND by balancing nitritation and denitritation. The microbial community and their predicated function results showed considerable nitrifiers and denitrificans were enriched in the ACMFCs, contributing to SND and power recovery. Further analyses showed that the NH4+-N could inhibit SND, but PBS and Rext had no obvious effects on this outcome. Co-occurrence network analysis demonstrated that power is positively correlated with COD and Rext; strong correlations between organic removal and COD, and between nitrogen removal and ammonia, conductivity, and C/N ratio were also noted. Trichostatin A molecular weight Overall, the appropriate control of such parameters is necessary to achieve efficient SND in ACMFCs for LCNW treatment.Airborne pollens cause pollinosis and have the potential to affect microphysics in clouds; however, the number of monitored species has been very limited due to technical difficulties for the morphotype identification. In this study, we applied an eDNA approach to the airborne pollen communities in the suburbs of the Tokyo metropolitan area in Japan, within a mixed urban, rural, and mountain landscape, revealing pollen seasonality of various taxa (a total of 78 families across the period) in the spring season (February to May). Those taxa distinctly shifted in the season, especially in the beginning of February and the middle of April. Air temperature shift was an obvious key factor to affect the airborne pollen community, while the influence of other meteorological factors, such as wind speed, humidity, and precipitation, was not clear. Taxonomic classification of major Amplicon Sequence Variants (ASVs) indicates multiple pollen sources, including natural forest, planted forest, roadside, park lands, and horticultural activities. Most major ASV belongs to Japanese cedar (Cryptomeria japonica), which is the most notable allergen that causes pollinosis in Japan, peaking in mid-February to March. Backward trajectory analysis of air masses suggests that the Japanese cedar and other Cupressaceae plantation forests in the western mountains were a significant source of airborne pollen communities detected at our sampling site. Other major plant pollen sources, including Japanese zelkova (Zelkova serrata) and ginkgo (Ginkgo biloba), emanated from the nearby parks or roadside regions. This study's approach enables us to visualize the phenology of multiple pollen, including timing and duration. Long-term monitoring of this type would provide additional insight into understanding the role of climate change on pollen transmission and links to flowering events.Low eutectic of lauric acid and stearic acid is one of drug loading candidates for its phase transformation at a certain temperature. Herein we demonstrated a combined photothermal-chemotherapy for breast cancer with near-infrared (NIR) triggered phase transition materials (PCM), which was conjugated with polydopamine (PDA) as the photosensitive agent. The PCM nanoparticles had diameters of ~75 nm based on scanning electron microscope (SEM) and dynamic laser scattering (DLS) measurement. Systematic in vitro and in vivo studies have been performed to investigate the stability, biosafety, photothermal performance, and drug delivery and release of PCM conjugates. Temperature measurement confirmed the prepared PDA modified material still showed strong photothermal effect after five cycles, which was higher than that of IR780 conjugated ones. In vivo photothermal imaging showed that the temperature of the tumor site reached 50.8 °C after 3 h of intravenous injection of PCM conjugates. More effective therapy of near-infrared (NIR)-assisted PDA-M@PCM in 4T1 bearing mice was witnessed when compared with that of non-NIR-assisted ones.
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