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The consequences associated with exercise while pregnant on placental arrangement: A planned out evaluate and also meta-analysis.
Objective The aim of the study was to investigate the influence of ethnicity and cerebroplacental ratio (CPR) on the birth weight (BW) of first generation Indo-Pakistan immigrants' newborns.Methods This was a retrospective study in a mixed population of 620 term Caucasian and Indo-Pakistan pregnancies, evaluated in two reference hospitals of Spain and Italy. All fetuses underwent a scan and Doppler examination within two weeks of delivery. The influence of fetal gender, ethnicity, GA at delivery, CPR, maternal age, height, weight and parity on BW was evaluated by multivariable regression analysis.Results Newborns of first generation Indo-Pakistan immigrants were smaller than local Caucasian newborns (mean BW mean= 3048 ± 435 g versus 3269 ± 437 g, p  less then  .001). Multivariable regression analysis demonstrated that all studied parameters, but maternal age and ethnicity, were significantly associated with BW. The most important were GA at delivery (partial R2 = 0.175, p  less then  .001), CPR (partial R2 = 0.032, p  less then  .001), and fetal gender (partial R2 = 0,029, p  less then  .001).Conclusions The propensity to a lower BW, explained by placental dysfunction but not by maternal ethnicity is transmitted to newborns of first generation immigrants. Whatever are the factors implied they persist in the new residential setting.Solanum chacoense (wild potato) is intensively used in breeding, its biochemical profile and putative human health-related traits being transferred into potato cultivars aimed for consumption. The goal of this study was to evaluate the biochemical profile and the anti-tumor potential of methanolic extracts obtained from S. chacoense leaves and tubers against three breast cancer cell lines in comparison to healthy endothelial cells (HUVEC). The biochemical profile of the extracts was determined by HPLC-PDA/-ESI+-MS and ITEX/GC-MS, the selective cytotoxicity by MTT assay whereas RT-qPCR was used to evaluate the expression of proliferation- and apoptosis-related genes. Both extracts proved to be rich in phenolic acids and volatile compounds, the leaf extract also containing glycoalkaloids. Both extracts proved to be cytotoxic for breast cancer cell lines, with IC50 values varying between 132.9 and 390.7 µg/ml. Both extracts had selective cytotoxicity against MCF7 cell line in comparison to HUVECs (selectivity coefficients >2.3). The treatment with the extracts induced overexpression of the pro-apoptotic gene BAX¸ down-regulation of the anti-apoptotic gene BCL-2 and the pro-proliferation genes NFkB, CCND1, and STAT3. Thus S. chacoense extracts proved to be rich in compounds with anticancer proprieties and are capable of inducing selective cytotoxicity on MCF7 cell line.Background Mutations in desmoplakin (DSP), the primary force transducer between cardiac desmosomes and intermediate filaments, cause an arrhythmogenic form of cardiomyopathy that has been variably associated with arrhythmogenic right ventricular cardiomyopathy (ARVC). Clinical correlates of DSP cardiomyopathy have been limited to small case series. Methods Clinical and genetic data were collected on 107 patients with pathogenic DSP mutations and 81 patients with pathogenic PKP2 mutations as a comparison cohort. A composite outcome of severe ventricular arrhythmia was assessed. Results DSP and PKP2 cohorts included similar proportions of probands (41% vs. 42%) and patients with truncating mutations (98% vs. 100%). Left ventricular (LV) predominant cardiomyopathy was exclusively present among DSP patients (55% vs. 0% for PKP2, p less then 0.001), whereas right ventricular (RV) cardiomyopathy was present in only 14% of DSP patients vs. 40% for PKP2 (p less then 0.001). ARVC diagnostic criteria had poor sensitiviFrequent PVCs were common among patients with severe arrhythmias for both DSP (80%) and PKP2 (91%) groups (p=NS). Conclusions DSP cardiomyopathy is a distinct form of arrhythmogenic cardiomyopathy characterized by episodic myocardial injury, left ventricular fibrosis that precedes systolic dysfunction, and a high incidence of ventricular arrhythmias. A genotype specific approach for diagnosis and risk stratification should be used.Objectives Although personal values guide one's life in several important aspects, no study has examined how personal values relate to mortality. The current study strives to fill this gap. I ask Which personal values prospectively predict mortality?Design A large population-based sample of middle-aged and older adults in Germany was used (N = 6089).Methods Personal values were measured in 2008 according to Schwartz using the Portraits Value Questionnaire. Mortality was monitored up to 2017, resulting in a maximum follow-up period of about 10 years.Results Using Cox survival regression analyses, I found that Self-direction and, in part, Benevolence predicted a decreased mortality risk. Conversely, Power predicted an increased mortality risk.Conclusions Thus, valuing independent thought and action (Self-Direction) and valuing the well-being of close others (Benevolence) seem to be associated with improved health, whereas valuing dominance and materialism (Power) is associated with diminished health. Future research should examine the mechanisms by which these personal values relate to mortality.Growing recognition and concerns of non-credible performance in pediatric populations have led clinicians to investigate the utility of performance and symptom validity tests (PVT/SVTs) among children and adolescents. Yet current research has indicated that a minority of clinicians routinely utilize a free-standing PVT in pediatric neuropsychological evaluations. The current article investigates the rationale for using PVT/SVTs, and the impact that failure of such exams have on other neurocognitive tests. read more A review of common adult PVTs and their appropriateness for use with specific pediatric clinical populations is presented, as well as empirical evidence for evaluating embedded validity indicators. The limited literature on SVTs with youth is also reviewed and provides additional insight into symptom exaggeration. There are various reasons children would provide noncredible performance, many of which are different from adults. A review of how the clinician should handle this behavior in pediatric evaluations is provided and what patient populations may present with a higher base rate of failure.
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