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With the acceleration of urbanization, the heat island effect, as a prominent feature of urban climate, has attracted more attention. Differences in urban landscape patterns have an essential impact on the urban thermal environment. The objective of the study is to examine the impact of urban landscape types and patterns on surface temperature. Taking Zhengzhou City, China, as an example, using Google Earth remote sensing images, an urban landscape type map was created, and landscape indices were calculated. The land surface temperature (LST) of the study area was retrieved by the Landsat-8 thermal infrared band. Correlation analysis indicated that the relationships between urban landscape patterns and the thermal environment were as follows (i) The scale indices (percentage of landscape (PLAND), largest patch index (LPI), edge density (ED), patch density (PD)) of urban landscape types with cooling effect (water body, riverfront area, park, high-rise building) were significantly negative correlated with mean LST of each partition. (ii) Conversely, there were significant positive correlations between the PLAND and LPI of landscape types with warming effect (block, development land, railway land) and the LST of the partition. (iii) The DIVISION index of the four kinds of landscapes with cooling effect was highly positively correlated with LST, and the DIVISION and SPLIT indices of the three kinds of landscapes with warming effect displayed a remarkable negative relationship with LST. Therefore, under the condition of scale control, integrated distribution of landscape with cooling effect, scattered distribution of landscape with warming effect, and reduced connectivity of landscape with warming effect will contribute to effectively alleviating the formation of urban heat islands.Carcinostatic effects of combined use of hydrogen nano-bubbles (nano-H) and platinum-povidone (PVP--Pt) were examined. Hydrogen-dissolved medium was prepared by hydrogen-gas bubbling with a microporous gas-emittance-terminal into a medium in the absence or presence of PVP-Pt (nano-H, nano-H/PVP-Pt). Human esophagus-derived carcinoma cells KYSE70 were repressed for cell proliferation with nano-H/PVP-Pt more markedly than with nano-H, indicating the hydrogen-intensification for PVP-Pt-alone-carcinostasis. However, the intensified carcinostasis required co-administration of nano-H and PVP-Pt, and no intensified carcinostasis was shown in two-step separate administration of nano-H and PVP-Pt. this website Furthermore, hydrogen bubbling into PVP-Pt-containing medium achieved more appreciable carcinostasis than mere addition of PVP-Pt into nano-H-containing medium, indicating the potent interaction of hydrogen and PVP-Pt. The nano-H/PVP-Pt-administered human tongue-derived carcinoma cells HSC-4 were repressed for cell proliferation more markedly than pre-malignant human tongue-derived epitheliocytes DOK, concurrently with more abundant intracellular Pt-intake into HSC-4 cells than DOK as analyzed by ICP-MS. Thus, PVP-Pt is able to adsorb hydrogen nano-bubbles on Pt and applicable for cancer therapy by diminishing the side-effects to normal cells.What determines the speed of our decisions? Various models of decision-making have focused on perceptual evidence, past experience, and task complexity as important factors determining the degree of deliberation needed for a decision. Here, we build on a sequential sampling decision-making framework to develop a new model that captures a range of reaction time (RT) effects by accounting for both working memory and instrumental learning processes. The model captures choices and RTs at various stages of learning, and in learning environments with varying complexity. Moreover, the model generalizes from tasks with deterministic reward contingencies to probabilistic ones. The model succeeds in part by incorporating prior uncertainty over actions when modeling RT. This straightforward process model provides a parsimonious account of decision dynamics during instrumental learning and makes unique predictions about internal representations of action values.
The COVID-19 pandemic has infected over > 11 million as of today people worldwide and is associated with significant cardiovascular manifestations, particularly in subjects with preexisting comorbidities and cardiovascular risk factors. Recently, a predisposition for arterial and venous thromboses has been reported in COVID-19 infection. We hypothesize that besides conventional risk factors, subjects with elevated lipoprotein(a) (Lp(a)) may have a particularly high risk of developing cardiovascular complications.
The Lp(a) molecule has the propensity for inhibiting endogenous fibrinolysis through its apolipoprotein(a) component and for enhancing proinflammatory effects such as through its content of oxidized phospholipids. The LPA gene contains an interleukin-6 (IL-6) response element that may induce an acute phase-type increase in Lp(a) levels following a cytokine storm from COVID-19. Thus, subjects with either baseline elevated Lp(a) or those who have an increase following COVID-19 infection, or bothlammatory effects. We propose studies to test the hypothesis that Lp(a) may contribute to cardiovascular complications of COVID-19.Fascial closure at 8-mm robotic port sites continues to be controversial. As the use of the robotic platform increases across multiple abdominal specialties, there are more case reports describing reoperation and small bowel resection for acute port-site hernias. A retrospective review of all robotic abdominal surgeries performed from 2012 to 2019 at NYU Langone Medical Center was conducted. Patients who had a reoperation in our facility within 30 days were identified, and medical records reviewed for indications for reoperation and findings. The study included 11,566 patients, of which 82 patients (0.71%) underwent a reoperation related to the index robotic surgery within 30 days. Fifteen of 11,566 patients (0.13%) had acute port-site hernias, and 3 of these 15 patients required small bowel resection. Eleven of 15 acute port-site hernias (73%) were at 8-mm robotic port site, 2 of which required a small bowel resection. More than a third of the patients had a hernia at an 8-mm port site where a surgical drain had been placed.
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