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62.1, p = 0.008), heart failure (63.3 vs. 32.4%, p less then 0.0001), and end-stage renal disease (ESRD) (60 vs. 25.7%) than ST-CLI patients. In addition, more vessels were affected in the NO-CLI group (5.2 ± 1.6 vs. 4 ± 1.5, p less then 0.0001), and there was more involvement of tibio-peroneal trunk (50 vs. 30.2%, p = 0.006), anterior tibial (93.3 vs. 82.7, p = 0.03), posterior tibial (93.3 vs. 73.7%, p = 0.0005), peroneal (70 vs. 48%, p = 0.002), and below-the-ankle arteries (73.3 vs. 39.1%, p less then 0.0001) than ST-CLI. The 1 year outcomes for the whole population were 69.9% limb salvage, 10.9% major amputation, and 19.2% death. The outcomes for NO-CLI and ST-CLI were, respectively, as follows limb salvage (13.8 vs. 73.4%, p less then 0.0001), amputation (30 vs. 4.5%, p = 0.0001), and mortality (50 vs. 8.9%, p less then 0.0001). NO-CLI patients showed a more severe pattern of peripheral arterial disease (PAD) with distal arterial lesions and worse outcomes than ST-CLI.
To assess whether a slackline intervention program improves postural control in children/adolescents with spastic cerebral palsy (CP).

Randomized controlled trial.

Patients' association.

Twenty-seven children/adolescents with spastic CP (9-16 years) were randomly assigned to a slackline intervention (
= 14, 13 ± 3 years) or control group (
= 13, 12 ± 2 years).

Three slackline sessions per week (30 min/session) for 6 weeks.

The primary outcome was static posturography (center of pressure-CoP-parameters). The secondary outcomes were surface myoelectrical activity of the lower-limb muscles during the posturography test and jump performance (countermovement jump test and Abalakov test). Overall (RPE, >6-20 scale) rating of perceived exertion was recorded at the end of each intervention session.

The intervention was perceived as "very light" (RPE = 7.6 ± 0.6). The intervention yielded significant benefits on static posturography (a significant group by time interaction on Xspeed,
= 0.006) and jump performance (a significant group by time interaction on Abalakov test,
= 0.015).

Slackline training improved static postural control and motor skills and was perceived as non-fatiguing in children/adolescents with spastic CP.
Slackline training improved static postural control and motor skills and was perceived as non-fatiguing in children/adolescents with spastic CP.The increasing demand for functional food is pushing the food industry to innovate the conventional and well-known foods. Producing functional foods, especially with probiotics in meat products, is an intricate and multistage task that involves the selection of microorganisms with probiotic potential, the identification at strain level, and the evaluation of probiotic strains in the processing of meat products. The resistance to digestion, followed by the successful colonization in the small intestine and the safety are the main criteria used to select and identify (at strain level) a probiotic, as reported in recent studies about the autochthonous microbiota of meat products. Further insertion (as starter culture) in a meat system for fermentation is the simplest approach to obtain a probiotic meat product. Among the innumerous microorganisms naturally found in meat products, lactic acid bacteria (LAB) play a central role by fitting in both probiotic and meat products processing criteria.Bacterial meningitis is an infectious pathology that remains a public health challenge. The most frequent etiological agent is Streptococcus pneumoniae, which is also associated with higher rates of mortality and sequels. However, less is known about the clinical presentation of atypical non-pneumoniae streptococcal meningitis. Here, we studied a 23-year-old man with no medical background who presented with projectile vomiting, states of consciousness alteration, unilateral cranial nerve palsy, and meningeal signs. Neuroimaging showed tonsillar herniation, regions of empyema, right transverse and sigmoid sinuses thrombosis, and multiple arterial subcortical infarcts. Cerebrospinal fluid suggested bacterial infection; blood and abscess cultures were positive for Streptococcus constellatus. The patient received antibiotics with no clinical improvement. JAK inhibitor He deteriorated over the following days, the abolishment of brainstem reflexes was observed, and brain death was declared. Streptococcal meningitis produced by atypical species is a potential cause of lethal cerebrovascular complications, even in immunocompetent patients.The aim of the present study was to quantify the impact of training restrictions, due to COVID-19 sanitary emergency, on physical and emotional strain of horse-riding Eventing competitions before and after eight weeks of lockdown. Performance was assessed by the penalty points attained, anxiety by the Competitive State Anxiety Inventory-2, strain by the Rating of Perceived Exertion (RPE) method. Moreover, Heart Rate was continuously monitored for fifty-four female national level Eventing horse-riders. Lockdown decreased performance outcome of horse-riders in Eventing competitions up to six weeks, with the Dressage test being the most affected discipline. Performance in Dressage was strongly related to both anxiety and session-RPE. After lockdown, Show-Jumping and Cross-Country courses were shorter allowing RPE to remain stable, session-RPE to significantly decline and cardiovascular strain not to exceed pre-lockdown values. In conclusion, emotional stress in Dressage and workload in Cross-Country should be carefully managed by equestrian Eventing stakeholders when planning training and competitions after a period of lockdown. Moreover, sRPE appears to offer a practical method of monitoring riders load during training and competition and could also be of use for home-based training during any future sport activities restrictions.
The COVID-19 outbreak had a major impact on healthcare systems worldwide. Our study aims to describe the characteristics and therapeutic emergency mobile service (EMS) management of patients with vital distress due to COVID-19, their in-hospital care pathway and their in-hospital outcome.

This retrospective and multicentric study was conducted in the six main centers of the French Greater East region, an area heavily impacted by the pandemic. All patients requiring EMS dispatch and who were admitted straight to the intensive care unit (ICU) were included. Clinical data from their pre-hospital and hospital management were retrieved.

We included a total of 103 patients (78.6% male, median age 68). In the initial stage, patients were in a critical condition (median oxygen saturation was 72% (60-80%)). In the field, 77.7% (CI 95% 71.8-88.3%) were intubated. Almost half of our population (45.6%, CI 95% 37.1-56.9%) had clinical Phenotype 1 (silent hypoxemia), while the remaining half presented Phenotype 2 (acute respiratory failure).
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