Notes

Varioxiranols A-G along with 19-O-Methyl-22-methoxypre-shamixanthone, PKS and also A mix of both PKS-Derived Metabolites from the Sponge-Associated Emericella variecolor Infection.
These 3 cases suggest that the virus plays a role in the clinical onset of the inflammatory/demyelinating disease.
To assess the kidney safety profile of mannitol in patients with malignant middle cerebral artery (MCA) infarction.

We studied consecutive patients with malignant MCA infarction (01/2008-01/2018). Malignant MCA infarction was defined according to DESTINY criteria. We compared clinical endpoints including acute kidney injury (AKI; according to Kidney Disease Improving Global Outcomes [KDIGO]) and dialysis between patients with and without mannitol. Multivariable model was built to explore predictor variables of AKI and in-hospital death.

Overall, 219 patients with malignant MCA infarction were included. Mannitol was administered in 93/219 (42.5%) patients with an average dosage of 650g (250-950g). Patients treated with mannitol more frequently suffered from AKI (39.8% vs. 11.9%; p<0.001) and required hemodialysis (7.5% vs. 0.8%; p=0.01) than patients without mannitol. At discharge, more patients in the mannitol group had persistent AKI than control patients (23.7% vs. selleck chemicals 6.4%, p<0.001). In multivariable model, mannitol emerged as independent predictor of AKI (OR 5.02, 95%CI 2.36-10.69; p<0.001).

Acute kidney injury appears to be a frequent complication of hyperosmolar therapy with mannitol in patients with malignant MCA infarction. Given the lack of evidence supporting effectiveness of mannitol in these patients, its routine use should be carefully considered.
Acute kidney injury appears to be a frequent complication of hyperosmolar therapy with mannitol in patients with malignant MCA infarction. Given the lack of evidence supporting effectiveness of mannitol in these patients, its routine use should be carefully considered.
Social participation is an important predictor of individual health outcomes, but few studies have examined it in the context of marriage relationships, even though the social lives of spouses are inextricably linked.

To examine whether individuals' mental health is associated with their spouse's contact with friends and family.

Using dyadic data from adults aged 50 and above in the Health and Retirement Study (N=5030 couples), I examine whether individuals' mental health is associated with their spouse's contact with friends and family (i.e., partner effects) through a longitudinal actor-partner interdependence model. In addition, I test for the presence of gender differences in these effects. Both depressive symptoms and binge drinking are used as measures of mental health to account for the different ways in which men and women may express psychological distress.

Results show partial evidence that spousal contact with friends and family are associated with one's own mental health outcomes, and that within-dyad discrepancies in informal social participation may be detrimental to mental well-being.

These findings highlight the importance of understanding the dynamics between social participation and health through the lens of "linked lives", especially for married couples.
These findings highlight the importance of understanding the dynamics between social participation and health through the lens of "linked lives", especially for married couples.Sight impairment is experienced by approximately 253 million people worldwide, including people of all generations, at all life course stages. Caught between past and present embodiments of the world, people often express feelings of loss with the onset of sight impairment. This paper examines the role of nonhuman nature encounters as a contingent resource amongst individuals navigating these emotional transitions. It responds to recent calls to attend to the life course in both critical disability studies and the growing body of work linking nonhuman nature relations to human wellbeing. The paper draws on findings from a qualitative study that combined in-depth narrative interviews with in situ go-along interviews to explore how 31 people with sight impairment in England describe and experience a sense of wellbeing (or otherwise) with nature across their everyday lives and life trajectories. The data were analysed using inductive narrative thematic analysis. While nonhuman nature encounters were valued by many participants in promoting a sense of freedom, relatedness, pleasurable sensory immersion, opportunities for exploration and 'skilling up', this paper cautions against generalised or overly Romantic tropes of what nonhuman nature can 'do' through key sight loss junctures, and for whom. It highlights the value of providing timely and sensitive social scaffolding and nurturing creativity to open up meaningful opportunities to engage with nonhuman nature and to counter feelings of loss exacerbated by identity-limiting life course narratives and disability stereotypes. Informed by the stories shared by participants to chart and situate their experiences of sight loss, we call for a new identity politics within and beyond the growing movement to 'connect' people to nonhuman nature for wellbeing; a politics that affirms diverse forms of more-than-human embodiment, recognising how and why such relations may weave into - and indeed out of - people's varied, interdependent life course trajectories.
Wuhan, the epicentre of the coronavirus diseases (COVID-19) outbreak, has been locked down on January 23, 2020. We conducted a study among the lay public in Wuhan to access their support, understanding of, compliance with, and the psychological impacts of the quarantine.

We conducted a cross-sectional, online-based survey study between January 28, 2020, and February 2, 2020 among the adult lay public in Wuhan to access their support, understanding of, compliance with, and the psychological impacts of the quarantine. Multivariable logistic analysis was used to identify factors associated with psychological impacts.

Among the 4100 participants investigated, a total of 15.9% were compliant with all the five household prevention measures, whereas 74.4% were compliant with all the three community prevention measures investigated. By demographics, participants of younger age, higher income, residing in an urban area, knowing neighbors infected with COVID-19 reported significantly higher psychological impact score.
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