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For every 10-μg/m3 increase in the PM2.5 concentration, the relative risk of daily ED admissions for circulatory system disease was 1.007 [95% confidence interval (CI), 1.001-1.013] in lag0, 1.007 (95%CI, 1.000-1.013) in lag1, and 1.011 (95%CI, 1.002-1.021) in lag03. A lag effect was found in IHD, a cumulative effect was found in CVE, and both lag and cumulative effects were found in hypertension and arrhythmia. A harvesting effect was observed in daily ED admissions for circulatory system disease and HF. We found no interaction between pollutants and temperature. We observed a monotonic and almost linear exposure-response relationship between PM2.5 and circulatory system disease with no threshold effect.PM2.5 contributes to obvious acute, lag, cumulative, and harvesting effects on circulatory system disease. PM2.5 was associated with the risk of daily ED admissions for circulatory system disease, hypertension, IHD, arrhythmia, HF, and CVE. Therefore, air quality management must be strengthened.Drought is a significant global constraint on agricultural production and food security. As a promising approach to improve plant growth and yield under challenging conditions, plant growth-promoting actinobacteria has attracted much interest. Further, elevated levels of atmospheric CO2 (eCO2) may promote the plant-actinobacteria interactions which could be effective to improve the plant growth for food production. GSK2982772 Herein, we have investigated the impact of actinobacteria and/or CO2 on biomass production, photosynthesis, macronutrients, levels of organic acids, amino acids, and essential oils as well as antioxidant activities of Satureja hortensis under water-deficit conditions. Among different actinobacterial isolates evaluated for development of secondary metabolites and biological activities, Ac9 was highly capable of producing flavonoids, and it also showed high antioxidant and microbial activities. It markedly induced the plant growth, photosynthesis, and global metabolic improvement, under water-deficit conditions. Interestingly, treatment with Ac9 in combination with eCO2 substantially minimized drought stress-induced biomass and photosynthesis reductions in Satureja hortensis. Improved photosynthesis by Ac9 and/or eCO2 induced the primary and secondary metabolisms in drought-stressed plants. The levels of the majority of the detected organic acids, essential oil, and amino acids were further improved as a result of the synergistic action of Ac9 and eCO2, as compared to the individual treatments. Furthermore, Ac9 or eCO2 significantly improved the antioxidant activities in stressed plants; however, much more positive impact was obtained by their synchronous application. Thus, the current study suggests that actinobacterial treatment induces global metabolic changes in water-stressed Satureja hortensis, the effects that have been much more strengthened under eCO2.Groundwater is a primary natural water source in the absence of surface water bodies. Groundwater in urban environments experiences unprecedented stress from urban growth, population increase, and industrial activities. This study assessed groundwater quality in terms of arsenic and heavy metal contamination in three industrial areas (Shahdara, Jhilmil, and Patparganj), Delhi, India. The water quality was assessed over a 3-year time interval (i.e., 2015 and 2018). The groundwater constituents investigated were As, Fe, Cr, Cd, Ni, Zn, Mn, Cu, and Pb. Metal index and heavy metal pollution indexes were estimated to assess groundwater pollution. The health risk was evaluated in terms of non-carcinogenic and carcinogenic risk assessment. Patparganj industrial area saw increment in concentration for Cu 0.23 mg/L (2015)-0.85 mg/L (2018), Zn 0.51 mg/L (2015)-7.2 mg/L (2018), Fe 0.32 mg/L (2015)-0.9 mg/L (2018), Cr 0.21 mg/L (2015)-0.26 mg/L (2018), Mn 0.14 mg/L (2015)-0.25 mg/L (2018), Ni 0.04 mg/L (2015)-0.34 mg/L (2018), and As 0.01 mg/L (2015)-0.18 mg/L (2018). Cd and Pb concentrations were observed to decrease by 40-90 % and 85-99% for all the three industrial areas. Metal index and heavy metal index values were found to be >1 for all locations. The risk quotient value > 1 was observed for all locations in the year 2015 but was found to increase further to a range of RQ 10-62 in the year 2018, inferring increased non-carcinogenic risk to consumers. The carcinogenic risk was significant with respect to Fe (0.2-0.7), Zn (0.001-0.007), and As (0.002-0.003) for all locations in the year 2015. This study concludes that groundwater in the three industrial areas is highly polluted and is not fit for human consumption. Further studies are required to explore possible control measures and develop methods to mitigate groundwater pollution, sustainable management, and optimized use to conserve it for future generations.The present cross-sectional study aimed to evaluate the risk factors for traffic noise-induced annoyance and also assess the awareness levels among the exposed population concerning the health impacts caused by traffic noise. Field measurements were made to validate the application of the standard noise models, which were later used to present the acoustical environment and assess the exposure level around a super-speciality hospital surrounded by a residential zone. Results from the noise maps and façade maps revealed that the area was exposed to noise levels exceeding the upper safe limits by more than 10 dB(A). The effect of exposure in the form of annoyance and the awareness level were evaluated using a questionnaire survey in a sample of 565 residents. Attention questions were incorporated in the questionnaire, and the awareness level was evaluated using the mean awareness index score. Respondents living in noisy areas were having a higher risk for annoyance as compared to those living in quiet areas (OR = 4.06; 95% CI = 2.79-5.88). Reporting poor sleep quality, being sensitive to noise, and noise perception at home were the significant risk factors for annoyance. Most of the respondents were classified as having no/little awareness about serious health ailments caused by traffic noise. Lower awareness levels, despite a higher literacy rate and a higher percentage of the young population, imply that there is a need for undertaking mass awareness programmes so that the impacts can be reduced to a minimum, if not eliminated.
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