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Dataset for your confirming regarding carcinoma from the exocrine pancreatic: tips in the Worldwide Effort on Cancers Reporting (ICCR).
BACKGROUND Metformin may reduce cancer risk and mortality and improve radiotherapy responses in several malignancies. OBJECTIVE To compare tumor responses and prognoses of metformin and non-metformin groups of diabetic patients receiving neoadjuvant concurrent chemoradiotherapy for rectal cancer. DESIGN Retrospective study. SETTING Single institution in the Republic of Korea. PATIENTS Between January 2000 and November 2017, 104 patients with rectal cancer taking diabetes medication and treated with neoadjuvant concurrent chemoradiotherapy followed by radical surgery were reviewed. Patients were divided into those taking (n=62) and not taking metformin (n=42). Tumor responses, survival, and other outcomes were analyzed. MAIN OUTCOME MEASURES Tumor response, rectal cancer-specific survival, and disease-free survival rates were measured. RESULTS Tumor regression grade (p=0.002), pathologic complete remission (p=0.037), and N downstaging (p less then 0.001) after neoadjuvant concurrent chemoradiotherapy were signients with lymph node downstaging after neoadjuvant concurrent chemoradiotherapy in rectal cancer with diabetes. See Video Abstract at http//links.lww.com/DCR/B185.BACKGROUND Prevention of venous thromboembolism after colorectal surgery remains challenging. National guidelines endorse thromboembolism prophylaxis for 4 weeks after colorectal cancer resection. Expert consensus favors extended prophylaxis after inflammatory bowel disease surgery. Actual frequency of prescription after resection remains unknown. OBJECTIVE To assess prescription of extended, post-discharge venous thromboembolism prophylaxis after resection in Michigan. DESIGN Retrospective review of elective colorectal resections within a statewide collaborative receiving post-discharge, extended duration prophylaxis. SETTING This study was conducted between October 2015 and February 2018 at an academic center. PATIENTS A total of 5722 patients (2171 with colorectal cancer, 266 with inflammatory bowel disease, 3285 with other). MAIN OUTCOME MEASURES We compared prescription of extended, post-discharge prophylaxis over time, between hospitals, and by indication. RESULTS Of 5722 patients, 373 (6.5%) received extended duration prophylaxis after discharge. Use was similar between patients undergoing surgery for cancer (282/2171, 13.0%) or inflammatory bowel disease (31/266, 11.7%, p=0.54), but was significantly more common for both compared with patients with other indications (60/3285, 1.8%, p300 beds) were significantly more likely to prescribe extended duration prophylaxis for all conditions (both p less then 0.001), with the majority of prophylaxis concentrated at only a few hospitals. LIMITATIONS This study was limited by lack of assessment of actual adherence, small number of observed venous thromboembolism events, small sample of inflammatory bowel disease patients, and restriction to state of Michigan. CONCLUSIONS Use of extended duration venous thromboembolism prophylaxis after discharge is increasing, but remains uncommon in most hospitals. Efforts to improve adherence may require quality implementation initiatives or targeted payment incentives. See Video Abstract at http//links.lww.com/DCR/B193.The objective of this study was to describe prehospital delay and health beliefs in Chinese patients with colorectal cancer. A total of 756 adult Chinese patients with a first-time diagnosis of colorectal cancer were recruited during 2016 in Guangzhou, China. All patients completed the Chinese-language version of a questionnaire developed specifically for this study as well as the Chinese-language version of the Champion Health Belief Model Scale. The results of this study showed that the median length of the prehospital delay was 12 weeks and that the average delay was 18.29 (SD = 14.66) weeks. The rate of prehospital delay was 47.35%. The score of health beliefs among these patients was 115.56 (SD = 9.00) and the average score of the entries was 3.21 (SD = 0.25). Health beliefs about colorectal cancer were negatively correlated with prehospital delay. A multiple logistic regression showed that the level of health beliefs, frequency of physical examinations, occupation, and the site of the cancer were the major factors influencing prehospital delay (p less then .05). The patients had a low rate of physical examination (41.40%), and colorectal cancer screening was not routine prior to their physical examination. This study showed that the incidence of prehospital delay among Chinese patients with colorectal cancer was 47.35%. Multiple factors influenced prehospital delay among Chinese patients with colorectal cancer.PURPOSE OF REVIEW Antiviral therapy for chronic hepatitis B infection is rarely curative, thus research in HBV cure strategies is a priority. Drug development and testing has been hampered by the lack of robust cell culture systems and small animal models. This review summarizes existing models for HBV cure research and focuses on recent developments since 2017 until today. RECENT FINDINGS The field has progressed in the development of cell culture and animal models to study HBV. Although early cell culture systems relied on transfection of HBV genomes in hepatoma cell lines, novel models expressing the entry receptor for HBV are susceptible to infection. Improved culture conditions for primary human hepatocytes, the primary target of HBV, have enabled the screening and validation of novel antivirals. this website Mouse models grafted with partially humanized livers are suitable for testing viral entry inhibitors or direct acting antivirals, and can be reconstituted with human immune cells to analyze immunotherapies. Other immunocompetent models include mice transduced with HBV genomes or woodchucks infected with their native hepatitis virus. SUMMARY Model systems for HBV research have helped lay the groundwork for the development and optimization of antiviral and immune-based therapeutic approaches that are now moving to clinical trials.PURPOSE OF REVIEW To present the most recent evidence on atopic dermatitis and its relation to food allergy. RECENT FINDINGS Atopic dermatitis is a chronic inflammatory disorder of the skin characterized by impaired skin barrier because of multifactorial causes including genetic factors, immune dysregulation, and skin microbiome dysbiosis. Infants with temporary skin barrier disruption and/or persistent atopic dermatitis are particularly at risk of developing food allergy (during the so-called atopic march), with up to half of patients demonstrating positive food-specific IgE and one-third of severe cases of atopic dermatitis having positive symptoms on oral food challenge. A high proportion of children with atopic dermatitis exhibit asymptomatic sensitization to foods, and skin testing to identify potential food triggers is not recommended unless the patient has a history suggestive of food allergy and/or moderate-to-severe atopic dermatitis unresponsive to optimal topical care. Indeed, indiscriminate testing can lead to a high proportion of false-positive tests and harmful dietary evictions.
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