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Persistent subdural hematoma waterflow and drainage underneath community anesthesia together with sleep vs . standard anesthesia and it is outcome.
To investigate factors related to benzodiazepine (BZD) resistance in status epilepticus (SE) with a focus on their relationship with the etiology of the episode.

All SE cases in patients aged >16years treated with BZDs were prospectively collected in our center from February 2011 to April 2019. The registry included demographics, SE type and etiology, the timing and duration of BZD administration, and the outcome. In total, 371 episodes were analyzed.

Median age at SE onset was 61.3years; the most frequent etiology was acute symptomatic (55.8%). SE with prominent motor symptoms occurred in 63.3%. Median time to BZD administration was 2h. We studied the correlation between two-time variables time from SE onset to BZD administration and time from BZD administration to resolution of SE (response); we observed that timely administration correlated with a faster response in patients with prominent motor symptoms (p=0.017), SE due to a chronic structural cerebral lesion (p=0.004), and patients with a history of seizures (p=0.013). Belnacasan In these subgroups (prominent motor symptoms or chronic structural lesion) BZD administration within the first 4.5h was highly associated with shorter post-BZD SE duration (p<0.001).

The relationship between prompt BZD administration and subsequent duration of SE was found to depend to some extent on the etiology of the episode patients with chronic structural lesions and those with previous epilepsy responded faster to BZDs. Semiology may have also its impact, as the presence of prominent motor symptoms showed also a faster response.
The relationship between prompt BZD administration and subsequent duration of SE was found to depend to some extent on the etiology of the episode patients with chronic structural lesions and those with previous epilepsy responded faster to BZDs. Semiology may have also its impact, as the presence of prominent motor symptoms showed also a faster response.Childhood and adolescence psychiatric disorders affect subsequent stages; early diagnosis of these disorders, such as attention-deficit/hyperactivity disorder (ADHD), is necessary. There is no reliable and valid diagnostic interview for ADHD in Asian Persian or Farsi speaking countries. The DSM 5-based version of the interview was sent to the 14 child and adolescent and general psychiatrists to ensure the validity of the ADHD section of the PAPA interview through an online website. Out of 59 health centers, 15 centers were selected via systematic random sampling. Three hundred children participated in the study. ADHD questions of the PAPA had the power to differentiate, with a sensitivity of 0.92, a specificity of 0.01. It had positive diagnostic value = 95.83 %, negative diagnostic value = 98.91 %, negative correlation ratio = 0.12, overall diagnostic accuracy = 98.67 % and diagnostic chance ratio = 2085.35. ADHD questions of the PAPA diagnostic interview can diagnose ADHD in preschool as a reliable tool based on DSM-5.
Precocious puberty (PP) is one of the most common endocrine disorders in school-age girls. It has been reported that there is an increased tendency for psychiatric disorders for early maturing girls. The aim of this study was to determine the prevalence of psychiatric problems and to investigate depression and anxiety levels, and self-concept characteristics in girls with PP.

Girls with PP (n = 41) and controls (n = 45) aged 7-11 years participated in this study. Psychiatric evaluations were conducted with semi-structured interviews. Behavioral and emotional problems were assessed using Child Behavior Check List and Teacher Report Form. Children's Depression Inventory, State-Trait Anxiety Inventory for Children and Piers-Harris Children's Self Concept Scale were administered, respectively.

Girls with PP had significantly more psychiatric diagnosis than controls (68.3 % vs 20 %, p < 0.001). PP group had significantly higher anxious-depressed, somatic complaints, social problems, aggresive behaviors and interestingly autistic traits. Increased symptom levels of depression and anxiety, and lower self-concept scores were also obtained from PP subjects.

PP is an independent predictor of psychiatric disorders. It is also associated with poorer psychiatric status, lower self esteem characteristics, and autistic traits. A multidisciplinary approach combining endocrinologic and psychiatric evaluations seem to be beneficial for the management of girls with PP.
PP is an independent predictor of psychiatric disorders. It is also associated with poorer psychiatric status, lower self esteem characteristics, and autistic traits. A multidisciplinary approach combining endocrinologic and psychiatric evaluations seem to be beneficial for the management of girls with PP.Significant efforts have been made to achieve efficient H2O2 generation via oxygen reduction reaction (ORR). Here, the acetylene black (AB)-based gas diffusion electrodes (GDEs) modified by PTFE were fabricated and applied in a closed autoclave for H2O2 generation for the first time. The surface morphology, BET, XPS, cyclic voltammetry curves and linear scanning voltammetry curves of GDEs were all characterized. Additionally, the H2O2 generation experiments of GDEs and the relationship between H2O2 yield and BET surface area (SBET), double layer capacitance (Cdl) were all investigated. It could be found that the SBET and Cdl of GDEs kept a good linear relationship with H2O2 content, and 2#GDE (ABPTFE = 13) possessed the optimal H2O2 generation capacity. Also, the effect of oxygen pressure and current density on H2O2 production was evaluated detailedly, indicating higher oxygen pressure was beneficial to the H2O2 generation and the preferable current density was 20 mA cm-2 due to the side reactions. And all the H2O2 electro-generation experiments exhibited a higher oxygen utilization efficiency (0.77%-2.93%). Finally, the efficient and synergetic electro-catalytic degradation of isophorone was achieved by self-made PbO2 anode and GDE.Polybrominated diphenyl ethers (PBDEs), a kind of flame retardants, were widely used in the furniture, textile and electronics industries. Because of their lipophilic, persistent and bio-accumulative properties, PBDEs were listed on the Stockholm Convention as typical persistent organic pollutants (POPs). We have previously reported that a highly active, quinone-type metabolite of PBDEs (PBDEQ) causes DNA damage and subsequently triggers apoptosis. However, it is remaining unclear whether PBDEQ provokes protein damage and stimulates corresponding signaling cascade. Using human normal liver (LO2) cells as an in vitro model, we demonstrated that PBDEQ causes oxidative protein damage through excess reactive oxygen species (ROS). Consistently, we found PBDEQ exposure causes the depletion of protein thiol group, the appearance of carbonyl group and the accumulation of protein aggregates. Endoplasmic reticulum (ER) stress was involved in the repair of oxidized proteins. Under the scenario of severe damage, LO2 cells degrade oxidized proteins through ubiquitin-proteasome system (UPS) and autophagy.
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