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Pulmonary arterial hypertension (PAH) is a devastating complication of Systemic Sclerosis (SSc). Screening for PAH in SSc has increased detection, allowed early treatment for PAH, and improved patient outcomes. Blood-based biomarkers that reliably identify SSc patients at risk of PAH, or with early disease, would significantly improve screening, potentially leading to improved survival, and provide novel mechanistic insights into early disease. The main objective of this study was to identify a proteomic biomarker signature that could discriminate SSc patients with, and without PAH using a Machine Learning approach, and to validate the findings in an external cohort.Serum samples from patients with SSc and PAH (n=77) and SSc without PH (non-PH, n=80) were randomly selected from the clinical DETECT study and underwent proteomic screening using the MYRIAD RBM discovery platform consisting of 313 proteins. Samples from an independent validation cohort (SSc-PAH, n=22 and non-PH, n=22) were obtained from University of Sheffield, UK. Random Forest (RF) analysis identified a novel panel of eight proteins, comprising Collagen IV, Endostatin, IGFBP-2, IGFBP-7, MMP-2, Neuropilin-1, NT-proBNP and RAGE, that discriminated PAH from non-PH in SSc patients in the DETECT discovery cohort (average area under the ROC values (ROC-AUC) of 0.741, 65.1% sensitivity / 69.0% specificity) was reproduced in the Sheffield cohort (81.1% accuracy, 77.3% sensitivity / 86.5% specificity). This novel 8-protein biomarker panel has the potential to improve early detection of PAH in SSc patients and may provide novel insights into the pathogenesis of PAH in the context of SSc.
Skin cancer is the most common cancer in the United States. Skin cancer is a broad term that includes squamous cell carcinoma, basal cell carcinoma, and melanoma. Melanoma is the most concerning of the three types of skin cancer and is the focus of this project. The projected number of individuals impacted by a new diagnosis of melanoma in 2020 is a staggering 100,350 coupled with an estimated 6,850 patients dying from melanoma each year. In Wisconsin, it is estimated there will be 2,190 new cases of melanoma, and 150 deaths in 2020. Expanding patient's knowledge about the risk and benefits of skin cancer screenings, techniques, and characteristics will enhance understanding of the significance of skin cancer.

The purpose of this study was to assess current skin cancer knowledge and raise awareness by providing education regarding skin cancer risks and statistics among manufacturing employees in Wisconsin.

A quality improvement procedure took place as employees of a Midwestern global manufacturer were eith this small group that simple skin cancer counseling offers great benefit in helping increase knowledge among those educated about skin cancer risk factors and sun protective behaviors.
Screening patients for obstructive sleep apnea (OSA) risk factors is an effective method for helping reduce adverse outcomes in conscious sedation. Patients receiving conscious sedation for endoscopy were not being screened for OSA at a rural hospital.

The purpose of this quality improvement project was to implement a nurse education program to improve OSA screening of endoscopy patients, using an evidence-based screening tool, and to increase nurse OSA knowledge and patient education.

This study was conducted in the outpatient perioperative section of a small rural hospital in northern Michigan. Data were obtained from pre/post chart review and nurse knowledge assessment. Twenty-eight nurses participated in an educational session that included OSA education and instructions on using the STOP-Bang questionnaire for OSA screening.

Nurse OSA knowledge increased from 75% preeducation program to 89% posteducation program. Use of the STOP-Bang Questionnaire for patients presenting for outpatient endoscopy procedures requiring conscious sedation and patient OSA education increased from 43.5% to 81.2% pre- to posteducation program.

This study's educational session was successful in promoting use of the STOP-Bang questionnaire among perioperative nurses and increasing education for patients screened positive for OSA.

Training nurses to use a brief OSA screening tool effectively improved the OSA screening of patients presenting for outpatient conscious sedation involving endoscopy.
Training nurses to use a brief OSA screening tool effectively improved the OSA screening of patients presenting for outpatient conscious sedation involving endoscopy.
Childhood vaccines prevent more than 10 million illnesses and 33,000 deaths in the United States each year. Noncompliance rates for children 2 and under are higher in underserved and resource poor communities.

The aim of this project was to develop and implement a five-step, direct-call reminder system to increase vaccination rates among children ages 2 and under presenting to a federally qualified health center (FQHC).

This project examined whether direct phone contact with parents can increase office visits to discuss vaccine status over a 6-week period following implementation of a five-step, direct-call reminder system.

47 parents/guardians were contacted from a list of 455 patients. Thirty-six percent of parents contacted scheduled and kept appointments.

This study found that the vaccines rates of a FQHC practice initiative are directly affected by methods of contact and knowledge of the vaccine schedule. Reaching out and discussing vaccine schedules with parents can increase vaccination rates. Yet, many of them have limited methods of contact.

A five-step, direct-call reminder system has a positive impact on vaccination compliance. Vaccination compliance is complicated, and approaches should be multifaceted.
A five-step, direct-call reminder system has a positive impact on vaccination compliance. Vaccination compliance is complicated, and approaches should be multifaceted.
Healthy People 2020 has introduced a new initiative focused on adolescent health, ages 10-17, and young adults, ages 18-25, due to health and social problems starting or peaking during these years. The initiative focuses on decreasing such problems including substance use. Cannabis is one of the most popular illegal substances used among young adults for recreation in the United States. βAminopropionitrile Multiple consequences of cannabis use are well documented in the literature including the development of medical problems, developmental delays, and social issues. Furthermore, academic success is linked to overall health outcomes.

The aim of this study was to explore cannabis use and knowledge of consequences among college students at a university in southwest Texas.

Secondary analysis of survey results from students at a small, private university. The Core Alcohol and Drug Survey, a self-report questionnaire, was utilized to measure alcohol and drug usage, attitudes, perceptions, and opinions regarding drug and alcohol usage.
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