Notes

Modulation regarding Endosome Function, Vesicle Trafficking as well as Autophagy by simply Individual Herpesviruses.
This study extrapolated that if two tumors are detected simultaneously, margin control can become more difficult, and breast-conserving surgery should be thoroughly reviewed.Gigantomastia is a rare complication of pregnancy usually associated with benign conditions and rarely with malignancies. This paper reports a non-Hodgkin lymphoma case associated with gigantomastia during pregnancy. The patient was a 30-year-old gravida one woman, with a history of rapidly enlarging right breast at 2 weeks prior to presentation. After the first diagnosis of benign gigantomastia, the continuous growth of the breast, despite the delivery and bromocriptine therapy, required further investigation of the case. The histological analysis revealed the presence of Burkitt lymphoma. Malignant causes of unilateral gigantomastia in pregnancy should be considered in the differential diagnosis of this condition.
This study aims to determine the capacity to tolerate discomfort by women who undergo mammography.

The data were obtained using the face-to-face interview method immediately after the procedure with women who undergo mammography (n=132). Demographic data collection form and the Discomfort Intolerance Scale was used for data collection.

Among the women, 78.8% experienced pain during mammography and the pain intensity was determined as 3.55 (standard deviation=3.00) on the 0-10 Visual Analogue Scale. Women who were not on pain relievers and nonsmokers have high discomfort tolerance. Women who were consuming substances containing methylxanthine (eg. chocolate) tend to avoid discomfort. Women with a history of breast mass and abnormal test results did not avoid discomfort as much as women who undergo regular checkup mammograms. Most of the women experience pain during mammography, and avoidance from discomfort increases as the perceived pain during the procedure increases.

Conducting different studies using the same scale can be useful in evaluating the discomfort experienced during mammography and its contribution to reducing pain.
Conducting different studies using the same scale can be useful in evaluating the discomfort experienced during mammography and its contribution to reducing pain.
This study aimed to evaluate various prognostic factors that play a vital role in stratifying and guiding tailored treatment strategies and survival outcome in breast cancer patients with brain metastases (BM).

Data regarding demography, clinical presentation, molecular subtypes, risk-stratification, treatment details, and outcomes were retrieved from medical records. All time-to-event (survival) outcomes were analyzed by Kaplan-Meir method and compared using log-rank test. Univariate and multivariate analysis of relevant prognostic factors were performed and p-values ≤0.05 were considered statistically significant.

A total of 88 patients (median age 50 years) were included for this study. The median follow-up time of all surviving patients was ~20 months. During the follow-up, 82 (93.1%) patients died. The median survival of all patients was 12 months, with 1-year and 2-year overall survival (OS) rate of 51% and 22%, respectively. Based on univariate analysis, statistically significant prognostic factoof patients.
This study aimed to provide further evidence on the accuracy of tumor size estimates and influencing factors.

In this cross-sectional study, patients with a biopsy-proven diagnosis of breast cancer referred to our hospital to obtain a preoperative magnetic resonance imaging (MRI) between 2015 and 2016 were included. Data from 76 breast cancer patients with 84 lesions were collected. Telaglenastat molecular weight All participants underwent ultrasonography and MRI, and their mammograms (MGMs) were reevaluated for tumor size estimation. Measurements by the three imaging modalities were compared with the pathologically determined tumor size to assess their accuracy. Influencing factors such as surgical management, molecular and histopathological subtypes, and Breast Imaging Reporting and Data System enhancement types in MRI were also assessed.

The rates of concordance with the gold standard were 64.3%, 76.2%, and 82.1% for MGM, ultrasound (US), and MRI measurements, respectively. Therefore, the highest concordance rate was observed in MMRIs present with non-mass enhancement or mass lesion with non-mass enhancement.
Breast cancer (BC) is the main cause of cancer-related deaths in women across the world. It can be classified into different subtypes, including triple-negative (TN), which is characterized by the absence of hormone receptors for estrogen and progesterone and the lack of the human epidermal growth factor receptor 2. These tumors have high heterogeneity, acquire therapeutic resistance, and have no established target-driven treatment yet. The identification of differentially expressed genes in TN breast tumors and the
validation of their prognostic role in these tumors.

We employed a microarray dataset and, by using the GEO2R tool, we identified a list of differentially expressed genes. The
validation was conducted using several online platforms including the KM Plotter, cBioPortal, bc-GenExMiner, Prognoscan, and Roc Plotter.

We observed that FZD9 was among the top differentially expressed genes in a cohort of patients with different TNBC subtypes. The FZD9 expression was significantly different in o confirm our findings and to strengthen the evidences about the mechanisms by which FZD9 functions in these tumors.
We aimed to analyze the clinicopathological findings, treatment approach, and treatmen outcomes in patients diagnosed with phyllodes tumor (PT).

The clinicopathological data of 26 patients with PT, who were treated between 2008 and 2019, were retrospectively analyzed.

Mean age was 35.07±13.95 years (range 14-71), while mean tumor size was 54.76±29.24 mm (range 25-135). Benign, borderline, and malignant PT were detected in 18 (69.2%), 3 (11.5%), and 5 (19.2%) patients, respectively. Marginless excision was performed in 20 patients (76.9%), while six (23.1%) patients underwent mastectomy. A statistically significant correlation of tumor type with mean tumor size and mean age was observed (p=0.041 and p=0.013, respectively). Margin positivity on first excision was more frequent in the malignant tumors (p=0.02). No statistically significant correlation of PT type with presence of breast cancer in the family history, and tumor localization was observed (p=0.79 and p=0.13, respectively). Mean postoperative follow-up duration was 56 months (range 6-147).
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