Notes

A clear case of occluded femoropopliteal saphenous vein bypass together with intimidating limb ischemia treated with endovascular stent graft relining.
This influx of more and novice visitors poses challenges for forest managers and urban forest policy. It is, however, also a unique opportunity for a substantial engagement of forestry with society at large, that has implications for forest policy, especially in urban areas, possibly beyond the COVID-19 pandemic era.This study evaluates the potential value of eudaimonic well-being in assessing pro-preventive orientation towards suicide and recognizing suicide as a solution. The aim was to integrate positive and negative conceptualizations of mental health for predicting attitudes towards suicide, and towards suicide prevention, among students of the helping professions. The study participants (166 women and 73 men, mean age 22.84 ± 5.15) answered a set of questionnaires, including a Questionnaire on Attitudes Towards Suicide, Goldberg Health Questionnaire (GHQ-28), Psychological Well-Being Scale (PWB-42) and Centrality of Religiosity Scale. Multiple regression analysis showed that environmental mastery, purpose in life and positive relationships, controlled for religiousness and psychological problems related to general mental health, predicted the variability of attitudes towards suicide and pro-preventive orientation. Sociodemographic variables were not related to attitudes towards suicide. Our findings suggest that positive mental health, represented jointly by low mental health problems and eudaimonic components of happiness, plays a role in predicting pro-preventive attitudes. Therefore, improving positive mental health among students in the helping professions, these being the future gatekeepers, could be considered an auxiliary strategy for suicide prevention.For the treatment of various viral infections, antiviral drugs may be used. Liquid chromatography-mass spectrometry (LC-MS) with tandem mass spectrometry (MS-MS) operated in selected-reaction monitoring (SRM) mode is the method of choice in quantitative bioanalysis of drugs, e.g., to establish bioavailability, to study pharmacokinetics, and later on possibly for therapeutic drug monitoring. In this study, the fragmentation in MS-MS of small-molecule antiviral drugs against herpes and influenza viruses is reviewed. In this way, insight is gained on the identity of the product ions used in SRM. Fragmentation schemes of antiviral agents are also relevant in the identification of drug metabolites or (forced) degradation products. As information of the fragmentation of antiviral drugs in MS-MS and the identity of the product ions is very much scattered in the scientific literature, it was decided to collect this information and to review it. In this third study, attention is paid to small-molecule antiviral agents used against herpes and influenza virus infections. In addition, some attention is paid to broad-spectrum antiviral agents, that are investigated with respect to their efficacy in challenging virus infections of this century, e.g., involving Ebola, Zika and corona viruses, like SARS-CoV-2, which is causing a world-wide pandemic at this very moment. The review provides fragmentation schemes of ca. 35 antiviral agents. The identity of the product ions used in SRM, i.e., elemental composition and exact-m/z, is tabulated, and more detailed fragmentation schemes are provided.Plasmonic nanoparticles based on conventional metals like gold (Au) and silver (Ag) has attracted significant attention of biosensor researchers. Core-shell nanoparticles (CSNP) have shown specific advantages by virtue of unique combination of strong field enhancement and wide ranging spectral tuneability of localized surface plasmon resonances (LSPR). In view of the remarkable plasmonic properties of refractory nitrides (e.g., ZrN and TiN) like higher degree of spectral tuneability, growth compatibility, high melting point, inherent CMOS and biocompatibility etc., and reported high surface area, excellent bio-molecular compatibility, improvement in the speed, higher sensitivity in graphene, the present work assess the feasibility of graphene coated refractory nitrides based CSNP as an efficient refractive index sensor. Mie theory is employed for the theoretical analysis and simulation of such plasmonic structures. The results reported in the present work have been corroborated using COMSOL. The comparison of plasmonic properties and sensing characteristics e.g., FWHM, quality factor, sensitivity and figure of merit is presented for graphene and silica based sensors. It is reported that the sensitivity = 171.68 (nm/RIU) and figure of merit = 3.57 × 104 (nm/RIU) can be attained. The present work suggests that graphene coated refractory nitrides based core-shell structures may emerge as ultrasensitive biosensor.Plastics have become a severe transboundary threat to natural ecosystems and human health, with studies predicting a twofold increase in the number of plastic debris (including micro and nano-sized plastics) by 2030. However, such predictions will likely be aggravated by the excessive use and consumption of single-use plastics (including personal protective equipment such as masks and gloves) due to COVID-19 pandemic. This review aimed to provide a comprehensive overview on the effects of COVID-19 on macroplastic pollution and its potential implications on the environment and human health considering short- and long-term scenarios; addressing the main challenges and discussing potential strategies to overcome them. HG106 inhibitor It emphasises that future measures, involved in an emergent health crisis or not, should reflect a balance between public health and environmental safety as they are both undoubtedly connected. Although the use and consumption of plastics significantly improved our quality of life, it is crucial to shift towards sustainable alternatives, such as bio-based plastics. Plastics should remain in the top of the political agenda in Europe and across the world, not only to minimise plastic leakage and pollution, but to promote sustainable growth and to stimulate both green and blue- economies. Discussions on this topic, particularly considering the excessive use of plastic, should start soon with the involvement of the scientific community, plastic producers and politicians in order to be prepared for the near future.
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