Notes

Uncoupling PIP2-calmodulin regulation of Kv7.2 programs through a good construction destabilizing epileptogenic mutation.
SARS-CoV-2 infection rarely causes acute bronchiolitis and it is not associated with a severe clinical course. During COVID-19 pandemic period there was a marked decrease in bronchiolitis cases.We conducted a narrative review of literature focused on Latinx youth in the Juvenile Justice System (JJS). The goal of this review was to identify the behavioral health needs and social and cultural factors that place Latinx youth at disproportionate risk for contact and entrenchment with the JJS. Ecodevelopmental Theory (ET) was used as the guiding framework for this review, and a total of 16 peer reviewed articles from Embase, PsychINFO, and Pubmed were collected, analyzed, and summarized. Consistent with ET, we organized themes from the literature into the following sections (a) microsystem (i.e., family, psychiatric care, sexual health care, school); (b) mesosystem (i.e., family and social environment); (c) exosystem (i.e., family and neighborhood context, and bicultural stress); and (d) macrosystem (i.e., generational status, cultural stress, social class). Sociopolitical disparities, such as disproportionate sentencing by social class and trauma stemming from political violence, and intersections of cultural variables (e.g., generational status and acculturation) should be closely considered in any prevention and intervention efforts targeting Latinx youths. More research to understand and address the unique needs of this population is also needed.The COVID-19 pandemic has become a crucial public health problem in the world that disrupted the lives of millions in many countries including the United States. In this study, we present a decision analytic approach which is an efficient tool to assess the effectiveness of early social distancing measures in communities with different population characteristics. First, we empirically estimate the reproduction numbers for two different states. Then, we develop an age-structured compartmental simulation model for the disease spread to demonstrate the variation in the observed outbreak. Finally, we analyze the computational results and show that early trigger social distancing strategies result in smaller death tolls; however, there are relatively larger second waves. Conversely, late trigger social distancing strategies result in higher initial death tolls but relatively smaller second waves. This study shows that decision analytic tools can help policy makers simulate different social distancing scenarios at the early stages of a global outbreak. CompK price Policy makers should expect multiple waves of cases as a result of the social distancing policies implemented when there are no vaccines available for mass immunization and appropriate antiviral treatments.Research on unethical leadership has predominantly focused on interpersonal and high-intensity forms of harmful leader behavior such as abusive supervision. Other forms of harmful leader behavior such as excessively pressuring subordinates or acting in self-centered ways have received less attention, despite being harmful and potentially occurring more frequently. We propose a model of four types of harmful leader behavior (HLB) varying in intensity (high vs low) and orientation (people/relationships or tasks/goals) Intimidation, Lack of Care, Self-Centeredness, and Excessive Pressure for Results. We map out how these relate to other constructs in the unethical leader behavior field in order to integrate the existing work on how leaders can cause harm to followers. Next, in five studies (N = 35, N = 218, N = 352, N = 160, N = 1921 in 196 teams), we develop and test a new survey instrument measuring the four proposed types of perceived HLB. We provide initial validity evidence for this new measure, establish its psychometric properties, and examine its nomological network by linking the four types of HLB to related leadership constructs and soft and hard outcome correlates at the individual and team level. We find that HLB is negatively related to constructive forms of leadership (e.g., ethical and transformational) and positively to unethical ones (e.g., abusive supervision). HLB is also related in the expected direction to job satisfaction, engagement, psychological safety, knowledge sharing, knowledge hiding, deviance, and objectively recorded team-level stress-related absenteeism.Post-traumatic stress disorder (PTSD) has always been controversial and highly politicized. Here, using a social identity approach, we review evidence that trauma and its aftermath are fundamentally linked to social position, sociopolitical capital, and power. We begin this contribution by demonstrating how a person's group memberships (and the social identities they derive from these memberships) are inherently linked to the experience of adversity. We then go on to consider how it is through group memberships that individuals are defined by their trauma risk and trauma histories-that is, a person's group memberships and their trauma are often inherently linked. Considering the importance of group memberships for understanding trauma, we argue that it is important to see these, and group processes more generally, as more than just "demographic" risk factors. Instead, we argue that when groups are defined by their trauma history or risk, their members will often derive some sense of self from this trauma. For this reason, attributes of group memberships are important in developing an understanding of adjustment and adaptation to trauma. In particular, groups' status, their recourse to justice, and the level of trust and solidarity within the group are all central to the impact of traumatic events on individual-level psychological resilience. We review evidence that supports this analysis by focusing on the exacerbating effects of stigma and social mistrust on post-traumatic stress, and the value of solidarity and strong identities for resilience. We conclude that because of these group-related processes, trauma interweaves the personal with the political and that post-traumatic stress is fundamentally about power, positionality, and politics.From the first notification reporting to the WHO a cluster of coronavirus in Wuhan City (China), over 114 million cases of SARS-CoV-2 have been confirmed, with more than 2,530,000 deaths, and over 400,000 new cases and 10,000 deaths daily. Numerous viruses are susceptible to contaminate crops during growth, harvesting, handling, marketing and minimally processing, and these steps share one common factor which is human. Different studies showed that viruses might persist on different crops for periods of 2 to 14 days under different conditions such as refrigeration, household and freezing. Little is known on SARS-CoV-2, but preliminary studies showed that this virus might survive 24 hr on cardboard and 72 hr on plastic, materials used in fruits and vegetables packaging. Based on preliminary data, there is no evidence of food or food packaging being associated with transmission of SARS-CoV-2. Certainly, to date there is no scientific evidence that SARS-CoV-2 might be transmitted by a contact with, or the ingestion of contaminated fresh or minimally processed fruits and vegetables.
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