Notes

MiR-144-3p induced by SP1 stimulates IL-1β-induced pyroptosis inside chondrocytes by way of PTEN/PINK1/Parkin axis.
At the same time, the selenized polysaccharides showed better immunomodulatory ability and could be used as new-type immunoenhancer. selleck chemical The present conclusions provided theoretical basis for the new application of dandelion polysaccharides and the development of dandelion resources.High-value utilization of cellulosic biomasses via the most promising enzymatic method is the key to solve a series of global strategic issues but its industrialization was seriously hindered by the high cost. Immobilization of enzyme to realize its recycling is one solution; however, how to capture and hydrolyze the insoluble cellulose effectively via the immobilization system remains challenging. Herein, inspired by the predation process of the sea anemone, a cost-effective biomimetic cellulase-loaded enzymatic film was constructed. The cellulase loaded on the film can adjust its spatial orientation freely, thus their catalytic centres can easily reach the surface of the cellulose to perform the "predation" process effectively. As a result, this immobilization system can largely increase the efficiency of the insoluble cellulose hydrolysis and can be recycled for at least 8 cycles without activities loss. Therefore, it can largely reduce the cost of the cellulose conversion in the industrial areas.Hydrogel beads composed of oxidized gellan gum (OGG) and resistant starch (RS) were successfully fabricated by ionic cross-linking and used as delivery carriers for resveratrol. Firstly, OGG with different degrees of oxidation were prepared through 2, 2, 6, 6-tetramethylpiperidine-1-oxyl radical (TEMPO)-mediated oxidation, and characterized by Fourier transform infrared spectroscopy and carbon-13 nuclear magnetic resonance to prove that carboxyl groups were successfully introduced into the gellan gum molecules. Molecular weight, thermal stability, zeta potential and gelation temperature of OGG were also investigated. Subsequently, resveratrol was encapsulated into OGG/RS hydrogel beads in the form of resveratrol/β-cyclodextrins inclusion complexes. The addition of RS significantly influenced the morphological structure and swelling capacity of OGG/RS hydrogel beads. The OGG/RS hydrogel beads exhibited a pH-sensitivity and high encapsulation efficiency of resveratrol (84.95 %-90.73 %). Furthermore, the in-vitro release behaviors demonstrated that OGG/RS hydrogel beads showed good stability in simulated gastric fluids and sustained release of resveratrol in simulated intestinal fluids. The obtained results indicate that OGG/RS hydrogel beads show a potential as delivery system for resveratrol in the food industry.The present study demonstrates the extrusion printing of highly viscous and thixotropic hydroxyethylcellulose-based bioinks blended with various concentrations of sodium alginate (SA) and embedded with HeLa cells. The cell viability is shown to be inversely proportional to the relative SA content and can be as high as 81.5 % following one day of incubation. Furthermore, the biocompatibility of the hydrogel matrix supports cell proliferation resulting in an order of magnitude larger number of cells after a 7-day incubation. The cell viability is negatively affected mostly by the extrusion printing itself with some cell death occurring during their embedding in the hydrogels. After embedding the HeLa cells in the blends containing 1 and 2.5 % SA, the cell viability is not significantly affected by the residence time of up to 90 min before the bioink extrusion. The printed constructs can be utilized as a cervical tumor model.Methylcellulose (MC) has received considerable attention because of its thermogelation behavior in aqueous solutions upon heating; however, the accompanied macro-phase separation results in demixing and detriment of thickening power. To alleviate this drawback, a novel family of hydrophilically modified methylcelluloses (HMMCs) was prepared by introducing acylamino, carboxyl, and amino groups onto MC side chains. Above association temperature (Tass), MC solutions experienced obvious macro-phase separation and thermothinning phenomenon; on the contrary, HMMCs solutions exhibited thermo- and salt-thickening behaviors, and Tass could be adjusted from 44 °C to 87 °C by altering the nature of HMMCs or salt content in solutions. The mechanism to eliminate the macro-phase separation of HMMC stems from the balance between hydrophilicity and hydrophobicity. This work opens a new avenue for cellulose derivatives to sustain their thermoviscosifying ability and widen their applications in hostile environments.With the aim to fulfill the patient-centered approach of precision medicine, in this research, innovative floating drug delivery systems have been developed through the use of alginate matrix and fully characterized. Particularly, to exploit the ionotropic gelation of alginate, a customized coaxial extruder for Semi-solid Extrusion 3D printing, has been used for the simultaneous dispensing of ink gel (sodium alginate 6% w/v) and crosslinking gel (hydroxyethyl cellulose 3 %w/v, calcium chloride 0.1M and Tween 85 0.1% v/v). The latter also loaded with Propranolol Hydrochloride 12.5%w/v. A novel single-step process gelation for the extemporaneous gelation of loaded oral systems has been therefore developed. These technologically advanced formulations showed high printing reproducibility in manufacturing different models (mass of a single layer 535.41 ± 40.00 mg with an average drug loading efficiency of 85% w/w) and similar release behavior, paving the way for their customization in terms of drug dosages via this pioneering process.A novel approach was introduced to prepare very low density, highly porous, economic, reusable, hydrophobic, and magnetic cellulose aerogels from hardwood dissolving pulp via a simple freeze-drying procedure. The aerogels showed outstanding adsorption efficiency for several oils and organic solvents and demonstrated excellent selectivity for absorbing oil from an oil/water mixture. Moreover, they were easily collected by an external magnet, indicating excellent recyclability and reusable for at least 10 cycles while still retaining supreme adsorption capacity (up to 181 g/g for silicone oil). This study proposes an economic and novel method for the large-scale preparation of hydrophobic and magnetic cellulose aerogels, making them a promising candidate for the efficient and sustainable cleaning of oils and chemical spills.
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