Notes

Circadian conduct involving Tectus (Trochus) niloticus from the southwest Pacific deduced via accelerometry.
Although Antarctica is considered one of the most pristine areas on Earth, an accelerating human presence in this remote continent, such as scientific operations and functioning of numerous scientific stations, logistics, and tourism activities, has increased the risks of environmental impacts in recent decades. During the 63rd Russian Antarctic expedition, 42 samples from topsoil horizons were collected from Larsemann Hills, Mirny station, and Fulmar Island, Eastern Antarctica. The purpose of this work was to analyze the accumulation levels 8 trace elements and to assess possible environmental risks associated with contamination of Antarctic soils. Various human activities have been found to be responsible for increase of metal levels in studied Antarctic environments. Our study also revealed a specific role of ornithogenic factor and moss cover in distribution of contaminants in severe conditions of Eastern Antarctica soils. Ornithogenic soils were characterized by higher rates of accumulation of some trace metals and metalloids (especially zinc and copper) compared with other investigated "pristine" sites without significantly visible traces of guano inputs. In general term, obtained geoaccumulation index for trace elements in all samples were under or slightly above the 0 level, indicating low to moderate pollution of the studied soils. Results of principal component analysis revealed the necessity for further detailed research on interactions of trace metals with soil organic matter for better understanding of their biogeochemistry in the Antarctic environment. Although most of contaminated sites were found in anthropogenically affected areas, accumulation of some elements in guano-derived and moss materials were associated with higher values for soil pollution indices in natural soils, as well.The present study aimed to evaluate the mechanism of action of the antineoplastic activity of an oxazolidine derivative, LPSF/NB-3 (5-(4-cloro-benzilideno)-3-etil-2-tioxo-oxazolidin-4-ona). Cytotoxicity assays were performed in peripheral blood mononuclear cells (PBMCs) and resistant acute leukemia cell line (HL-60/MX1) by the MTT method. LPSF/NB-3 exhibited cytotoxicity in HL-60/MX1, but it was not toxic to healthy cells in the highest dose tested (100 μM). The protein extract of HL-60/MX1 cells treated with LPSF/NB-3 was subjected to proteomic analysis using two-dimensional chromatography coupled to mass spectrometry. We could identify a total of 2652 proteins, in which 633 were statistically modulated. Within the group of protein considered for the quantitative analysis with the established criteria, 262 were differentially expressed, 146 with increased expression and 116 with decreased expression in the sample treated with LPSF/NB-3 compared to the control. The following differentially expressed pathways were found involving regulation of the cytoskeleton, DNA damage, and transduce cellular signals. Networks that were highlighted are related to the immune system. The ELISA technique was used to assess the immunomodulatory potential of LPSF/NB-3 in PBMCs. We observed significant decrease of IFNγ (p less then 0.01) and dose-response pattern of the cytokines IL-6, IL-17A, IL-22, and IL-10. Therefore, results suggest that LPSF/NB-3 appears to modulate important pathways, including cell cycle and immune system regulatory pathways.
The coronavirus disease 2019 (COVID-19) pandemic has caused major disruptions in the US health care system.

To estimate frequency of and reasons for reported forgone medical care from March to mid-July 2020 and examine characteristics of US adults who reported forgoing care.

This survey study used data from the second wave of the Johns Hopkins COVID-19 Civic Life and Public Health Survey, fielded from July 7 to July 22, 2020. Citarinostat Respondents included a national sample of 1337 individuals aged 18 years or older in the US who were part of National Opinion Research Center's AmeriSpeak Panel.

The initial period of the COVID-19 pandemic in the US, defined as from March to mid-July 2020.

The primary outcomes were missed doses of prescription medications; forgone preventive and other general medical care, mental health care, and elective surgeries; forgone care for new severe health issues; and reasons for forgoing care.

Of 1468 individuals who completed wave 1 of the Johns Hopkins COVID-19 Civic Life and Pu4%]; P = .002) and financial concerns (36 of 186 respondents [20%] vs 28 of 503 respondents [6%]; P = .001). Respondents lacking health insurance were more likely to attribute forgone care to financial concerns than respondents with Medicare or commercial coverage (19 of 88 respondents [22%] vs 32 of 768 respondents [4%]; P < .001). Frequency of and reasons for forgone care differed in some instances by race/ethnicity, socioeconomic status, age, and health status.

This survey study found a high frequency of forgone care among US adults from March to mid-July 2020. Policies to improve health care affordability and to reassure individuals that they can safely seek care may be necessary with surging COVID-19 case rates.
This survey study found a high frequency of forgone care among US adults from March to mid-July 2020. Policies to improve health care affordability and to reassure individuals that they can safely seek care may be necessary with surging COVID-19 case rates.
The Patient Protection and Affordable Care Act (ACA) temporarily increased primary care practitioners' (PCP) Medicaid fees to that of Medicare for 2013 to 2014 (fee bump) to help accommodate potential increases in demand for care with ACA coverage expansion. This also increased fees for PCPs treating dual-eligible Medicare and Medicaid beneficiaries in many states and eliminated payment differentials for dual-eligible vs non-dual-eligible Medicare beneficiaries that could limit access to care.

To examine the association between the ACA fee bump and primary care visits for dual-eligible Medicare and Medicaid beneficiaries.

This cohort study used a difference-in-difference design and Medicare claims data from 2012 to 2016 to compare changes in visit rates for full-subsidy dual-eligible Medicare and Medicaid beneficiaries vs non-dual-eligible Medicare beneficiaries with low income whose fees did not change. Changes were examined overall and separately in states with temporary, extended, or minimal fee increases for dual-eligible vs non-dual-eligible beneficiaries in 2013 to 2014 (mandatory bump) and 2015 to 2016 (postbump or bump extension) vs 2012 (prebump).
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