Notes

Second Tier Screening to Reduce the volume of Non-actionable Supplementary Conclusions and also False-Positive Testimonials and referrals in New child Verification pertaining to Serious Mixed Immunodeficiency.
The risk assessment conducted by the European Food Safety Authority stated some concerns regarding the chronic exposure of the European population to nickel due to food intake. This study aimed to evaluate the extent of the Belgian population's exposure to nickel via intake of different foods/drinks available in their market. Avadomide Ni concentrations were measured in selected foods consumed in Belgium, and exposures from this limited group of foods were estimated for consumers of these foods. Legumes, soy products, breakfast cereals, and chocolate spreads were responsible for 26%, 14%, 11% and 8% of the overall exposure (overall chronic exposure through consuming all the included food types in this study except tap water) of children (3-9 years) to nickel. For adolescents (10-17 years), the highest percentage of overall chronic exposure again originated from legumes (19%). This was followed by breakfast cereals (14%), soy products (11%) and chocolate spreads (11%). For adults (18-64 years), major contributors to the overall chronic daily exposure were legumes (16%), dark chocolate (15%) and breakfast cereals (10%). The aggregate exposure assessment, including the highest contaminated foods, for different sub-populations, revealed mean exposure levels of 1.02, 0.60 and 0.34 μg kg-1 b.w. day-1 for children, adolescents, and adults respectively. The mean, P75, P90 and P95 values for aggregate chronic exposure of the overall consumer's population were 0.62, 0.80, 1.5 and 210 μg kg-1 b.w. day-1 respectively. This study recommends controlling the intake of food products with elevated nickel content especially for the more vulnerable sub-population groups such as children with lower body weight and nickel sensitised individuals. It also demonstrates a shift in potential risk on human health to nickel exposure due to the transition towards a more plant-based diet.Pesticides present in water resources can cause adverse health effects even in low concentrations, due to their bio-accumulative character. Therefore, the challenge for drinking water production increases, due to the limitations of conventional water treatment technologies in the removal of small molecular weight dissolved compounds. This work aimed to provide technical and scientific support for the selection of pulverized activated carbon - PACs, granular activated carbon - GACs, and carbon nanotubes - CNT concerning atrazine - ATZ, simazine - SMZ, and diuron - DIU adsorption for application in water treatment plants, considering two forms of application commercial product - CP and analytical standard - SD. These forms of application were tested aiming to verify the influence of the purity of the products used in experiments on the adsorption efficiency. It was possible to verify the adsorption efficiencies were not guided only by the characteristics of the adsorptive materials used, and that the selection should not be carried out only based on the, specific superficial area - BET size and distribution of specific pore volume. The isotherms demonstrated that the parameter Kf associated with the results of the selection experiment can be considered an alternative technical tool of simple application and sufficient for this purpose. Also, the capacity of activated carbons - ACs and nanomaterials - NMs were affected by the application of the compounds, highlighting the importance of using commercial product - CP in scientific research and technical investigations.Purpose This study provided reference data and examined psychometric properties for clausal density (CD; i.e., number of clauses per utterance) in children between ages 4 and 9 years from the database of the Edmonton Narrative Norms Instrument (ENNI). Method Participants in the ENNI database included 300 children with typical language (TL) and 77 children with language impairment (LI) between the ages of 4;0 (years;months) and 9;11. Narrative samples were collected using a story generation task, in which children were asked to tell stories based on six picture sequences. CD was computed from the narrative samples. The split-half reliability, concurrent criterion validity, and diagnostic accuracy were evaluated for CD by age. Results CD scores increased significantly between ages 4 and 9 years in children with TL and those with LI. Children with TL produced higher CD scores than those with LI at each age level. In addition, the correlation coefficients for the split-half reliability and concurrent criterion validity of CD scores were all significant at each age level, with the magnitude ranging from small to large. The diagnostic accuracy of CD scores, as revealed by sensitivity, specificity, and likelihood ratios, was poor. Conclusions The finding on diagnostic accuracy did not support the use of CD for identifying children with LI between ages 4 and 9 years. However, given the attested reliability and validity for CD, reference data of CD from the ENNI database can be used for evaluating children's difficulties with complex syntax and monitoring their change over time. Supplemental Material https//doi.org/10.23641/asha.13172129.Purpose The aim of this study is to investigate whether human auditory frequency tuning can be influenced by tonal language experience. Method Perceptual tuning measured via psychophysical tuning curves and cochlear tuning derived via stimulus-frequency otoacoustic emission suppression tuning curves in 14 native speakers of a tonal language (Mandarin) were compared to those of 14 native speakers of a nontonal language (English) at 1 and 4 kHz. Results Group comparisons of both psychophysical tuning curves (p = .046) and stimulus-frequency otoacoustic emission suppression tuning curves (p = .007) in the 4-kHz region indicated sharper frequency tuning in the Mandarin-speaking group relative to the English-speaking group. The auditory tuning was better at the higher (4 kHz) than the lower (1 kHz) probe frequencies (p less then .001). Conclusions The sharper auditory tuning in the 4-kHz cochlear region is associated with long-term tonal language (i.e., Mandarin) experience. Experience-dependent plasticity of tonal language may occur before the sound signal reaches central neural stages, as peripheral as the cochlea.
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